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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 10
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Research Article

Urinary metabolites of doxapram in premature neonates

R. T. Coutts Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada, T6G 2N8; Division of Newborn Medicine, Royal Alexandra Hospital, 10240 Kingsway, Edmonton, Canada, T5H 3V9
,
F. Jamali Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada, T6G 2N8
,
F. Malek Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada, T6G 2N8
,
A. Peliowski Division of Newborn Medicine, Royal Alexandra Hospital, 10240 Kingsway, Edmonton, Canada, T5H 3V9
&
N. N. Finer Division of Newborn Medicine, Royal Alexandra Hospital, 10240 Kingsway, Edmonton, Canada, T5H 3V9
Pages 1407-1418 | Received 10 Nov 1990, Accepted 03 Jun 1991, Published online: 22 Sep 2008

References

  • Aranda J. V., Beharry K., Rex J., Linder N., Blanchard P. High pressure liquid chromatographic microassay for simultaneous measurement of doxapram and its metabolites in premature newborn infants. Journal of Liquid Chromatography 1988; 11: 2983–2991
  • Barrington K. J., Finer N. N., Torok-Both G. A., Jamali F., Coutts R. T. Dose response relationship of doxapram in the therapy of refractory idiopathic apnoea of prematurity. Pediatrics 1987; 80: 22–27
  • Birkholz D. A., Coutts R. T., Hrudey S. E. Uptake and biotransformation of 6,7-dimethylquinoline and 6,8-dimethylquinoline by rainbow trout (Salmo gairdneri). Xenobiotica 1989; 19: 695–710
  • Clements J. A., Robson R. H., Prescott L. F. The disposition of intravenous doxapram in man. European Journal of Pharmacology 1979; 16: 411–416
  • Jamali F., Barrington K. J., Finer N. N., Coutts R. T., Torok-Both G. A. Doxapram dosage regimen in apnea of prematurity based on pharmacokinetic data. Developmental Pharmacology Therapeutic 1988; 11: 253–257
  • Jamali F., Coutts R. T., Malek F., Finer N. N., Peliowski A. Lack of a pharmacokinetic interaction between doxapram and theophylline in apnea of prematurity. Developmental Pharmacology and Therapeutics 1991; 16: 78–82
  • LeGatt D. F., Beaudry M. A., Bradley J. M. Simultaneous determination of doxapram and 2-ketodoxapram in plasma of neonates by gas chromatography. Journal of Chromatography 1986; 378: 478–481
  • Nichol H., Vine J., Thomas J., Moore R. G. Quantitation of doxapram in blood, plasma and urine. Journal of Chromatography 1980; 182: 191–200
  • Pitts J. E., Bruce R. B., Forehand J. B. Identification of doxapram metabolites using high pressure ion exchange chromatography and mass spectroscopy. Xenobiotica 1973; 3: 73–83
  • Robson R. H., Prescott L. F. A pharmacokinetic study of doxapram in patients and volunteers. British Journal of Clinical Pharmacology 1978; 7: 81–87
  • Torok-Both G. A., Coutts R. T., Jamali F., Pasutto F. M., Barrington K. J. Sensitive nitrogen-phosphorus capillary gas chromatographic assay for doxapram in premature infants. Journal of Chromatography 1985; 344: 372–377

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