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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 11
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Research Article

Verofylline pharmacokinetics in dietary-induced obese rats: Role of fat mass and protein binding in determining volume of distribution

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Pages 1419-1430 | Received 20 Mar 1988, Accepted 22 May 1991, Published online: 22 Sep 2008

References

  • Abernethy D. R., Greenblatt D. J. Pharmacokinetics of drugs in obesity. Clinical Pharmacokinetics 1982; 7: 108–124
  • Abernethy D. R., Greenblatt D. J. Drug disposition in obese humans. Clinical Pharmacokinetics 1986; 11: 199–213
  • Abernethy D. R., Greenblatt D. J., Divoll M., Harmatz J. S., Shader R. I. Alteration in drug distribution and clearance due to obesity. Journal of Pharmacology and Experimental Therapeutics 1981; 217: 681–685
  • Abernethy D. R., Greenblatt D. J., Divoll M., Shader R. I. Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam and acetaminophen. Journal of Laboratory and Clinical Medicine 1983; 101: 873–880
  • Abernethy D. R., Todd E. L., Schwartz J. B. Caffeine disposition in obesity. British Journal of Clinical Pharmacology 1985; 20: 61–66
  • Altman P. L., Dittmer D. S. Biological Data Book. Federation of American Societies of Experimental Biology, Washington, DC 1964
  • Buss P., Leopold O., Smith A. P., Routledge P. A. Determinants of the plasma protein binding of theophylline in health. British Journal of Clinical Pharmacology 1983; 15: 339–405
  • Campbell T. C., Hayes J. R. Role of nutrition in the drug-metabolizing enzyme system. Pharmacology Review 1974; 26: 171–197
  • Dole V. A relation between non-esterified acids in plasma of the metabolism of glucose. Journal of Clinical Investigation 1956; 35: 150–154
  • Gal P., Jusko W. J., Yurchak A. M., Franklin B. A. Theophylline disposition in obesity. Clinical Pharmacology and Therapeutics 1978; 23: 438–444
  • Gigon P. L., van Hees H., Bickel M. H. A technique for the comparison of biological distribution and solvent partition of drugs. Experientia 1983; 39: 801–804
  • Gillette J. R. Factors affecting drug metabolism. Annals of the New York Academy of Sciences 1971; 179: 43–66
  • Grassi C., Casali L., Rampulla C., Rossi A. Clinical efficacy trial: theophylline vs (dl) 3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione. International Journal of Clinical Pharmacology and Therapeutic Toxicology 1980; 18: 518–522
  • Jusko W. J., Gardner M. J., Mangione A., Schentag J. J., Koup J. R., Vance J. W. Factors affecting theophylline clearance: Age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol. Journal of Pharmaceutical Sciences 1979; 68: 1358–1366
  • Kappas A., Anderson K. E., Conney A. H., Alvares A. P. Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Clinical Pharmacology and Therapeutics 1976; 20: 643–653
  • Mendez J., Kollias J. Diet and starvation on the composition and calculated density of fat-free body mass. American Journal of Physiology 1977; 42: 731–734
  • Mickelsen O., Takahashi S., Craig C. Experimental obesity. Journal of Nutrition 1955; 57: 541–554
  • Nosadini R., Ursini F., Tessari P., Garotti M. C., De Biasi F., Tiengo A. Hormonal and metabolic characteristics of genetically obese Zucker and dietary Sprague-Dawley rats. European Journal of Clinical Investigation 1980; 10: 113–118
  • Riggs D. S., Guarnieri J. A., Addelman S. Fitting straight lines when both variables are subject to error. Life Sciences 1977; 22: 1305–1306
  • Rocci M. L., Jr, Jusko W. J. LAGRAN program for area and moments in pharmacokinetic analysis. Computer Programs in Biomedicine 1983; 16: 203–216
  • Rohrbaugh T. M., Danish M., Ragui M. C., Yaffe S. J. The effect of obesity in apparent volume of distribution of theophylline. Pediatric Pharmacology 1982; 2: 75–83
  • Rothwell N. J., Stock M. J. In vivo determination of body composition by tritium dilution in the rat. British Journal of Nutrition 1979; 41: 625–628
  • Shum L., Jusko W. J. Theophylline disposition in obese rats. Journal of Pharmacology and Experimental Therapeutics 1984; 228: 380–386
  • Shum L., Jusko W. J. Reversed-phase high-performance liquid chromatographic determination of verofylline in rat serum. Journal of Chromatography 1986; 382: 207–213
  • Shum L., Jusko W. J. Theophylline tissue partitioning and volume of distribution in normal and dietary-induced obese rats. Biopharmaceutics and Drug Disposition 1989; 8: 353–364
  • Todd E. L., Abernethy D. R., Mitchell J. R. Tissue distribution of ± verapamil in obese and lean Zucker rats. Pharmacologist 1985; 27: 245
  • Toon S., Rowland M. Structure-pharmacokinetic relationships among the barbiturates in the rat. Journal of Pharmacology and Experimental Therapeutics 1983; 225: 752–763
  • Van Biervliet J. P., De Wijn J. E. Blood lipid values in obese children. Acta Paediatrica Belgium 1978; 31: 27–34
  • Vesell E. S. Complex effect of diet on drug disposition. Clinical Pharmacology and Therapeutics 1984; 36: 285–296
  • Watanabe J., Kozaki A. Relationship between partition coefficients and apparent volumes of distribution for basic drugs. Chemical and Pharmaceutical Bulletin 1978; 26: 3463–3470
  • Young R. C., Lucas S. G., Morris E. A., Dittman J., Rachal R. E., Malveaux F. J., Booker W. M. Verofylline, a methylxanthine bronchodilator, in asthma. Clinical Pharmacology and Therapeutics 1984; 36: 811–816
  • Zar J. H. Two sample hypotheses. Biostatistical Analysis. Prentice-Hall, Englewood Cliffs, NJ 1984; 132–133

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