Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 11
21
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Identification of a hydroxy metabolite of diflunisal in rat and human urine

, , , , &
Pages 1521-1533 | Received 28 Jan 1991, Accepted 12 Jul 1991, Published online: 22 Sep 2008

References

  • Cotton M. L., Hux R. A. Diflunisal. Analytical Profiles of Drug Substances, K. Florey. Academic Press, New York 1985; Vol. 14: 491–526
  • Dickinson R. G., King A. R. Reactivity considerations in the analysis of glucuronide and sulfate conjugates of diflunisal. Therapeutic Drug Monitoring 1989; 11: 712–720
  • Dickinson R. G., King A. R., Verbeeck R. K. Elimination of diflunisal as its acyl glucuronide, phenolic glucuronide and sulfate conjugates in bile-exteriorized and intact rats. Clinical and Experimental Pharmacology and Physiology 1989; 16: 913–924
  • Dickinson R. G., Verbeeck R. K., King A. R. Absence of phenolic glucuronidation and enhanced hydroxylation of diflunisal in the homozygous Gunn rat. Xenobiotica 1991; 11: 1535–1546
  • Faed E. M. Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs. Drug Metabolism Reviews 1984; 15: 1213–1249
  • Grootveld M., Halliwell B. 2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism. Biochemical Pharmacology 1988; 37: 271–280
  • Gunn C. H. Hereditary acholuric jaundice in a new mutant strain of rats. Journal of Heredity 1938; 29: 137–139
  • Levy G. Pharmacokinetics of salicylate in man. Drug Metabolism Reviews 1979; 9: 3–19
  • Leyden D. E., Cox R. H. Analytical Applications of NMR. John Wiley & Sons, New York 1977; 186–189; 491–526
  • Lin J. H., Hooke K. F., Yeh K. C., Duggan D. E. Dose-dependent pharmacokinetics of diflunisal in rats: dual effects of protein binding and metabolism. Journal of Pharmacology and Experimental Therapeutics 1985a; 235: 402–406
  • Lin J. H., Yeh K. C., Duggan D. E. Effect of enterohepatic circulation on the pharmacokinetics of diflunisal in rats. Drug Metabolism and Disposition 1985b; 13: 321–326
  • Lin J. H., Ulm E. H., Duggan D. E. Possible mechanisms for reduced plasma clearance of diflunisal in rat experimental renal failure. Journal of Pharmacology and Experimental Therapeutics 1986; 238: 978–984
  • Lin J. H., Chen I.-W., Ulm E. H., Duggan D. E. Differential effects of phenobarbital on ester and ether glucuronidation of diflunisal in rats. Journal of Pharmacology and Experimental Therapeutics 1987; 242: 1013–1018
  • Lin J. H., Deluna F. A., Tocco D. J., Ulm E. H. Effect of experimental diabetes on elimination kinetics of diflunisal in rats. Drug Metabolism and Disposition 1989; 17: 147–152
  • Loewen G. R., Herman R. J., Ross S. G., Verbeeck R. K. Effect of dose on the glucuronidation and sulphation kinetics of diflunisal in man: single dose studies. British Journal of Clinical Pharmacology 1988; 26: 31–39
  • Loewen G. R., Macdonald J. I., Verbeeck R. K. High-performance liquid chromato-graphic method for the simultaneous quantitation of diflunisal and its glucuronide and sulfate conjugates in human urine. Journal of Pharmaceutical Sciences 1989; 78: 250–255
  • Loewen G. R., McKay G., Verbeeck R. K. Isolation and identification of a new major metabolite of diflunisal in man. The sulfate conjugate. Drug Metabolism and Disposition 1986; 14: 127–131
  • Macdonald J. I., Herman R. J., Verbeeck R. K. Sex-differences and effect of smoking and oral contraceptive steroids on the glucuronidation/sulfation of diflunisal. European Journal of Clinical Pharmacology 1990; 38: 175–179
  • Roy A. B. The chemistry of sulfate esters and related compounds. Sulfation of Drugs and Related Compounds, G. J. Mulder. CRC Press, Boca Raton 1981; 5–30
  • Tocco G. J., Breault G. O., Zacchei A. G., Steelman S. L., Perrier C. V. Physiological disposition and metabolism of 5-(2′,4-difluorophenyl)salicylic acid, a new salicylate. Drug Metabolism and Disposition 1975; 3: 453–466
  • Verbeeck R. K., Dickinson R. G. The role of sulfate conjugation in the elimination kinetics of diflunisal in the rat. Drug Metabolism and Disposition 1990; 18: 267–268
  • Verbeeck R. K., Loewen G. R., Macdonald J. I., Herman R. J. The effect of multiple dosage on the kinetics of glucuronidation and sulphation of diflunisal in man. British Journal of Clinical Pharmacology 1990; 29: 381–389

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.