Absence of phenolic glucuronidation and enhanced hydroxylation of diflunisal in the homozygous Gunn rat

References

• Burchell B., Coughtrie M. W. H. UDP-glucuronosyltransferases. Pharmacology and Therapeutics 1989; 43: 261–289
   PubMed Web of Science ®Google Scholar
• Celier C., Cresteil T. Induction of drug-metabolizing enzymes in Gunn rat liver—effect of polycyclic aromatic hydrocarbons on cytochrome P-450 regulation. Biochemical Pharmacology 1989; 38: 2825–2832
   PubMedGoogle Scholar
• Coughtrie M. W. H., Burchell B., Bend J. R. Characterisation of the inherited deficiency of UDP-glucuronyl transferase activities in the Gunn rat. Drug Metabolism—From Molecules to Man, D. J. Benford, J. W. Bridges, G. G. Gibson. Taylor and Francis, London 1987; 171–175
   Google Scholar
• Dickinson R. G., King A. R. Absence of diflunisal phenolic glucuronide formation in the homozygous Gunn rat. Clinical and Experimental Pharmacology and Physiology 1987, Suppl. 12: 147
   Google Scholar
• Dickinson R. G., King A. R. Reactivity considerations in the analysis of glucuronide and sulfate conjugates of diflunisal. Therapeutic Drug Monitoring 1989; 11: 712–720
   PubMed Web of Science ®Google Scholar
• Dickinson R. G., Harland R. C., Ilias A. M., Rodgers R. M., Kaufman S. N., Lynn R. K., Gerber N. Disposition of valproic acid in the rat: dose-dependent metabolism, distribution, enterohepatic recirculation and choleretic effect. Journal of Pharmacology and Experimental Therapeutics 1979; 211: 583–595
   PubMed Web of Science ®Google Scholar
• Dickinson R. G., King A. R., Verbeeck R. K. Elimination of diflunisal as its acyl glucuronide, phenolic glucuronide and sulfate conjugates in bile-exteriorized and intact rats. Clinical and Experimental Pharmacology and Physiology 1989; 16: 913–924
   PubMed Web of Science ®Google Scholar
• Dutton G. J. Strain differences in glucuronidation. Glucuronidation of Drugs and Other Compounds. CRC Press, Boca Raton 1980; 129–134
   Google Scholar
• Fournel-Gigleux S., Hamar-Hansen C., Motassim N., Antoine B., Mothe O., Decolin D., Caldwell J., Siest G. Substrate specificity and enantioselectivity of arylcarboxylic acid glucuronidation. Drug Metabolism and Disposition 1988; 16: 627–634
   PubMed Web of Science ®Google Scholar
• Gunn C. H. Hereditary acholuric jaundice in a new mutant strain of rats. Journal of Heredity 1938; 29: 137–139
   Google Scholar
• Hansen-Møller J., Dalgaard L., Hansen S. H. Reversed-phase high-performance liquid chromatographic assay for the simultaneous determination of diflunisal and its glucuronides in serum and urine—rearrangement of the 1-O-acylglucuronide. Journal of Chromatography 1987; 420: 99–109
   PubMed Web of Science ®Google Scholar
• Houston J. B. Drug metabolite kinetics. Pharmacology and Therapeutics 1982; 15: 521–552
   Web of Science ®Google Scholar
• Kapitulnik J., Hardwick J. P., Ostrow J. D., Webster C. C., Park S. S., Gelboin H. V. Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats. Biochemistry Journal 1987; 242: 297–300
   PubMed Web of Science ®Google Scholar
• Lin J. H. The role of sulfate conjugation in the elimination kinetics of diflunisal in the rat: response. Drug Metabolism and Disposition 1990; 18: 268–269
   Google Scholar
• Lin J. H., Hooke K. F., Yeh K. C., Duggan D. E. Dose-dependent pharmacokinetics of diflunisal in rats: dual effects of protein binding and metabolism. Journal of Pharmacology and Experimental Therapeutics 1985; 235: 402–406
   PubMed Web of Science ®Google Scholar
• Lin J. H., Chen I. W., Ulm E. H., Duggan D. E. Differential effects of phenobarbital on ester and ether glucuronidation of diflunisal in rats. Journal of Pharmacology and Experimental Therapeutics 1987; 242: 1013–1018
   PubMed Web of Science ®Google Scholar
• Loewen G. R., McKay G., Verbeeck R. K. Isolation and identification of a new major metabolite of diflunisal in man—the sulfate conjugate. Drug Metabolism and Disposition 1986; 14: 127–131
   PubMed Web of Science ®Google Scholar
• Loewen G. R., Herman R. J., Ross S. G., Verbeeck R. K. Effect of dose on the glucuronidation and sulphation kinetics of diflunisal in man: single dose studies. British Journal of Clinical Pharmacology 1988; 26: 31–39
   PubMed Web of Science ®Google Scholar
• Macdonald J. I., Dickinson R. G., Reid R. S., Edom R. W., King A. R., Verbeeck R. K. Identification of a hydroxy metabolite of diflunisal in rat and human urine. Xenobiotica 1991; 21: 1521–1533
   PubMed Web of Science ®Google Scholar
• McKinnon G. E., Dickinson R. G. Covalent binding of diflunisal and probenecid to plasma protein in humans: presistence of the adducts in the circulation. Research Communications in Chemical Pathology and Pharmacology 1989; 66: 339–354
   PubMedGoogle Scholar
• Mulder G. J. Kinetics of sulfation in the rat in vivo and in the perfused rat liver. Federation Proceedings 1986; 45: 2229–2234
   PubMedGoogle Scholar
• Musson D. G., Lin J. H., Lyon K. A., Tocco D. J., Yeh K. C. Assay methodology for quantification of the ester and ether glucuronide conjugates of diflunisal in human urine. Journal of Chromatography 1985; 337: 363–378
   PubMed Web of Science ®Google Scholar
• Reilly P. E. B., Thompson D. A., Mason S. R., Hooper W. D. Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam. Molecular Pharmacology 1990; 37: 767–774
   PubMed Web of Science ®Google Scholar
• Tephly T., Green M., Puig J., Irshaid Y. Endogenous substrates for UDP-glucuronosyltransferases. Xenobiotica 1988; 18: 1201–1210
   PubMed Web of Science ®Google Scholar
• Tephly T. R., Townsend M., Green M. D. UDP-glucuronosyl-transferases in the metabolic disposition of xenobiotics. Drug Metabolism Reviews 1989; 20: 689–695
   PubMed Web of Science ®Google Scholar
• Tocco D. J., Breault G. O., Zacchei A. G., Steelman S. L., Perrier C. V. Physiological disposition and metabolism of 5-(2′,4′-difluorophenyl)salicyclic acid, a new salicylate. Drug Metabolism and Disposition 1975; 3: 453–466
   PubMed Web of Science ®Google Scholar
• Verbeeck R. K., Dickinson R. G. The role of sulfate conjugation in the elimination kinetics of diflunisal in the rat. Drug Metabolism and Disposition 1990; 18: 267–268
   PubMedGoogle Scholar
• Verbeeck R. K., Loewsn G. R., Macdonald J. I., Herman R. J. The effect of multiple dosage on the kinetics of glucuronidation and sulphation of diflusinal in man. British Journal of Clinical Pharmacology 1990; 29: 381–389
   PubMedGoogle Scholar
• Watkins J. B., Klaassen C. D. Induction of UDP-glucuronosyl-transferase activities in Gunn, heterozygous, and Wistar rat livers by pregnenolone-16α-carbonitrile. Drug Metabolism and Disposition 1982; 10: 590–594
   PubMed Web of Science ®Google Scholar
• Watt J. A., Dickinson R. G. Reactivity of diflunisal acyl glucuronide in human and rat plasma and albumin solutions. Biochemical Pharmacology 1990; 39: 1067–1075
   PubMed Web of Science ®Google Scholar
• Watt J. A., King A. R., Dickinson R. G. Contrasting systemic stabilities of the acyl and phenolic glucuronides of diflunisal in the rat. Xenobiotica 1991; 21: 403–415
   PubMed Web of Science ®Google Scholar