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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 12
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Research Article

Metabolic disposition of enciprazine, a non-benzodiazepine anxiolytic drug, in rat, dog and man

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Pages 1591-1604 | Received 19 Jun 1991, Accepted 01 Oct 1991, Published online: 22 Sep 2008

References

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  • Caccia S., Fong M. H., Garattini S., Notarnicola A. 1-Aryl-piperazines as active metabolites of drugs with aryl-piperazine side-chain. Biochemical Pharmacology 1985; 34: 393–394
  • Caccia S., Garattini S. 1-Arylpiperazines as active metabolites of (4-substituted aryl-1-piperazinyl)alkyl heterocyclic drugs. Acta Pharmacologica Jugoslavia 1990; 40: 441–460
  • Haskins J. T., Jones D. E., Scerni R., Muth E., Andree T. Preclinical pharmacological studies of Wy-48,624 (Enciprazine), a novel anxiolytic agent. Society for Neuroscience, Abstracts 1988; 14: 206
  • Lyon R. A., Titeler M., McKenney J. D., Magee P. S., Glennon R. A. Synthesis and evaluation of phenyl and benzoylpiperazines as potential serotonergic agents. Journal of Medicinal Chemistry 1986; 29: 630–634
  • Nickel B., Szelenyi I. Comparison of changes in the EEG of freely moving rats induced by enciprazine, buspirone and diazepam. Neuropharmacology 1989; 28: 799–803
  • Schweizer E., Rcikels K., Csanalosi I., London J., Turner D. A placebo-controlled study of enciprazine in the treatment of generalized anxiety disorder: a preliminary report. Psychopharmacology Bulletin 1990; 26: 215–217

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