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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 2
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Research Article

Disposition of bepridil in laboratory animals and man

W. N. Wu The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
,
J. F. Pritchard Glaxo Inc., 5 Moore Drive, Research Triangle Park, NC, 32, USA
,
K. T. Ng The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
,
J. F. Hills The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
,
J. A. Uetz The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
,
K. A. Yorgey The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
,
L. A. McKown The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
&
P. J. O'neill Ethicon Inc., Somerville, NJ, 32, USA
 show all
Pages 153-169 | Received 22 Jan 1991, Accepted 16 Aug 1991, Published online: 22 Sep 2008

References

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  • Cosnier D., Duchene-Marullaz P., Rispat G., Streichenberger G. Cardiovascular pharmacology of bepridil (1[3 isobutoxy 2(benzylphenyl)amino]propyl pyrrolidine hydrochloride) a new potential anti-anginal compound. Archives Internationales de Pharmacodynamie et de Therapie 1977; 225: 133–151
  • Desiraju R. K., Gemzik B., Nayak R. K., Easterling D. E. Steady-state dose proportionality and pharmacokinetics of bepridil in healthy volunteers. Clinical Pharmacology and Therapeutics 1984; 35: 234
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  • Ng K. T., Pritchard J. F., Hills J. F., McKown L. A., Plutte J. A., Yorgey K. A., O'Neill P. J. Comparative studies on the absorption, excretion, and biotransformation of bepridil (Bp) in mouse, rat, rabbit, and monkey. Pharmacologist 1983; 25: 114
  • Ng K. T., Hills J. F., Wu W. N. The absorption, excretion, and biotransformation of bepridil HCl (Bp) in man. Federation Proceedings 1984a; 43: 655
  • Ng K. T., Plutte J. A., Galante L. J. Determination of bepridil in biological fluids by high-performance liquid chromatography. Journal of Chromatography 1984b; 309: 125–131
  • Nieuwenhuyse H. Metabolism and kinetics of the anti-ischemic drug bepridil in man, rat, and dog. First International Symposium for Foreign Compound Metabolism 1983; 50, Abstract
  • Pritchard J. F., McKown L. A., Dvorchik B. H., O'Neill P. J. Plasma protein binding of bepridil. Journal of Clinical Pharmacology 1985; 25: 347–353
  • Tillement J. P., Albengres E., Urien S., Defer G., Pognat J. F. Metabolisme et pharmacocinetique du bepridil chez l'homme. Revue de Medicine 1983; 28: 1265
  • Wong K. K., Yang J. T., Chando T., Kucharczyk N., Perhach J. L. Metabolic patterns of (14C)-bepridil in urine and bile of rhesus monkeys after single oral dose. Pharmacologist 1981; 23: 170
  • Wu W. N., Ng K. T., Hills J. F., Chang S. Y., Dvorchik B. H., O'Neill P. J. Metabolism of bepridil (Bp) in mouse, rat, rabbit, monkey, and man. Federation Proceedings 1984; 43: 559

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