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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 4
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Original Article

Metabolism of albendazole and albendazole sulphoxide by ruminal and intestinal fluids of sheep and cattle

C. E. Lanusse Institute of Parasitology of McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste-Anne de Bellevue, Québec, Canada, H9X 1C0
,
B. Nare Institute of Parasitology of McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste-Anne de Bellevue, Québec, Canada, H9X 1C0
,
L. H. Gascon Institute of Parasitology of McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste-Anne de Bellevue, Québec, Canada, H9X 1C0
&
R. K. Prichard Institute of Parasitology of McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste-Anne de Bellevue, Québec, Canada, H9X 1C0
Pages 419-426 | Received 03 Jun 1991, Accepted 03 Oct 1991, Published online: 27 Aug 2009

References

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  • Delatour P., Cure M. C., Benoit E., Garnier F. Netobimin (Totabin-SCH): preliminary investigations on metabolism and pharmacology. Journal of Veterinary Pharmacology and Therapeutics 1986; 9: 230–234
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  • Gyurick R., Chow A., Zaber B., Brunner E., Miller J., Villani A., Petra L., Parish R. Metabolism of albendazole in cattle, sheep, rats and mice. Drug Metabolism and Disposition 1981; 9: 503–508
  • Hennessy D. R. Examination and manipulation of the pharmacokinetic behaviour of benzimidazole anthelmintics. Macquarie University, Australia 1985, Ph.D thesis
  • Lacey E. Mode of action of benzimidazoles. Parasitology Today 1990; 6: 112–115
  • Lanusse C. E., Prichard R. K. Pharmacokinetic behaviour of netobimin and its metabolites in sheep. Journal of Veterinary Pharmacology and Therapeutics 1990; 13: 170–178
  • Lanusse C. E., Trudeau C., Ranjan S., Prichard R. K. Pharmacokinetic profiles of netobimin metabolites after oral administration of zwitterion and trisamine formulations of netobimin to cattle. Journal of Veterinary Pharmacology and Therapeutics 1991a; 14: 101–108
  • Lanusse C. E., Gascon L. H., Prichard R. K. Gastrointestinal distribution of albendazole metabolites following the administration of netobimin to cattle: Relationship with plasma disposition kinetics. Journal of Veterinary Pharmacology and Therapeutics 1991b, in press
  • Lubega G. W., Prichard R. K. Interaction of benzimidazole anthelmintics with Haemonchus contortus tubulin: Binding affinity and anthelmintic efficacy. Experimental Parasitology 1991; 73: 203–213
  • Marriner S. E., Bogan J. A. Pharmacokinetics of albendazole in sheep. American Journal of Veterinary Research 1980; 41: 1126–1129
  • McKellar Q. A., Scott E. W. The benzimidazole anthelmintic agents—review. Journal of Veterinary Pharmacology and Therapeutics 1990; 13: 223–247
  • Prichard R. K., Hennessy D. R., Steel J. W., Lacey E. Metabolite concentrations in plasma following treatment of cattle with five anthelmintics. Research in Veterinary Science 1985; 39: 173–178
  • Renwick A. G., Strong H. A., George C. F. The role of the gut flora in the reduction of sulphoxide containing drugs. Biochemical Pharmacology 1986; 35: 64

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