Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 8
21
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Lacidipine metabolism in rat and dog: identification and synthesis of main metabolites

, , , , &
Pages 899-916 | Received 08 Oct 1991, Accepted 20 Mar 1992, Published online: 22 Sep 2008

References

  • Beresford A. P., Macrae P. V., Stopher D. A. Metabolism of amlodipine in the rat and the dog: a species difference. Xenobiotica 1988; 18: 169–182
  • Carpi C., Gaviraghi G., Semeraro C. GX 1048 (GR 43659X) a new dihydropyridine calcium antagonist with potent and long lasting antihypertensive action. British Journal of Pharmacology 1986; 89(Proc. Suppl.)758P
  • Higuchi S., Sasaki H., Shiobara Y., Sado T. Absorption, excretion and metabolism of a new dihydropyridine diester cerebral vasodilator in rats and dogs. Xenobiotica 1977; 7: 469–479
  • Medenwald H., Schlobmann K., Wünsche C. Strukturaufklärung der renalen ausscheidungsprodukte von (4-(2-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsäuredi methylester. Arzneimittel-Forschung 1972; 22: 53–56
  • Meyer H., Wehinger E., Bossert F., Sherling D. Nimodipine: synthesis and metabolic pathway. Arzneimittel-Forschung 1983a; 33: 106–112
  • Meyer H., Scherling D., Karl W. Nitrendipine: identification and synthesis of main metabolites. Arzneimittel-Forschung 1983b; 33: 1528–1534
  • Micheli D., Collodel A., Semeraro C., Gaviraghi G., Carpi C. Lacidipine: a calcium antagonist with potent and long-lasting antihypertensive effects in animal studies. Journal of Cardiovascular Pharmacology 1990; 15(Suppl. 4)666–675
  • Parinov V. J., Odinec A. G., Gilev A. P., Dubur G. J., Muceniece D. H., Ozol J. J., Shatz V. D., Gavars M. P., Vigante B. A. Pharmacokinetics and metabolism of ryodipine in rats. Arzneimittel-Forschung 1985; 35: 808–813
  • Pellegatti M., Grossi P., Ayrton J., Evans G. L, Harker A. J. Absorption, distribution and excretion of lacidipine, a dihydropyridine calcium antagonist, in rat and dog. Xenobiotica 1990; 20(8)765–777
  • Scheeling D., Karl W., Ahr G., Ahr H. J., Wehinger E. Pharmacokinetics of nisoldipine III. Biotransformation of nisoldipine in rat, dog, monkey and man. Arzneimittel-Forschung 1988; 38: 1105–1110
  • Takayama F., Iwasawa Y., Saito K., Shiratori K., Ohtawa M. Metabolism of a new dihydropyridine calcium antagonist in rats and dogs. Xenobiotica 1989; 19: 1407–1420
  • Terashita S., Tokuma Y., Fujiwara T., Shiokawa Y., Okumura K., Noguchi H. Metabolism of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs. Xenobiotica 1987; 17: 1415–1425
  • Walkenstein S. S., Intoccia A. P., Flanagan T. L., Hwang B., Flint D., Weinstock J., Villani A. J., Blackburn D., Green H. Metabolism of the antihypertensive agent 1,4-dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridine dicarboxylic acid diethylester. Journal of Pharmaceutical Science 1973; 62: 580–584
  • Weidolf L., Borg K. O., Hoffmann K.-J. Urinary metabolites of felodipine, a new vasodilating drug, in man, dog, rat and mouse. Xenobiotica 1984; 14: 657–666

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.