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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 8
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Research Article

The metabolism of cypermethrin in man: differences in urinary metabolite profiles following oral and dermal administration

B. H. Woollen ICI Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, Cheshire, SK10 4TJ, UK
,
J. R. Marsh ICI Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, Cheshire, SK10 4TJ, UK
,
W. J. D. Laird ICI Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, Cheshire, SK10 4TJ, UK
&
J. E. Lesser ICI Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, Cheshire, SK10 4TJ, UK
Pages 983-991 | Received 18 Feb 1992, Accepted 20 May 1992, Published online: 22 Sep 2008

References

  • Bartlett N., Hubbell J. Percutaneous absorption of topically applied 14C-permethrin in volunteers. Burroughs Wellcome Co., Research Triangle park, NC, Report No. THRS/86/0047
  • Chester G., Hatfield L. D., Hart T. B., Leppert B. D., Swaine H., Tummon O. J. Worker exposure to, and absorption of cypermethrin during aerosol application of an ‘ultra low volume’ formulation to cotton. Archives of Environmental Contamination and Toxicology 1987; 16: 69–78
  • Crawford M. J., Croucher A., Hutson D. H. The metabolism of the pyrethroid insecticide cypermethrin in rats; excreted metabolites. Pesticide Science 1981a; 12: 339–411
  • Crawford M. J., Croucher A., Hutson D. H. Metabolism of cis- and trans-cypermethrin in rats. Balance and tissue retention study. Journal of Agricultural and Food Chemistry 1981b; 29: 63–66
  • Eadsforth C. V., Baldwin M. K. Human dose-excretion studies with the pyrethroid insecticide cypermethrin. Xenobiotica 1983; 13: 67–72
  • Eadsforth C. V., Bragt P. C., Van Sittert N. J. Human dose-excretion studies with pyrethroid insecticides cypermethrin and alpha-cypermethrin: relevance to biological monitoring. Xenobiotica 1988; 18: 603–614
  • FAO/WHO. Pesticide Residues in Food, 1981. 1982; 79–112, Cypermethrin FAO Plant Production and Protection Paper, 42
  • Hutson D. H., Gaughan L. C., Casida J. E. Metabolism of the cis- and trans-isomers of cypermethrin in mice. Pesticide Science 1981; 12: 385–398
  • Ramsey J. D., Woollen B. H., Auton T. R., Batten P. L., Leeser J. E. Pharmacokinetics of fluazifop-butyl in human volunteers. II. Dermal dosing. Human and Experimental Toxicology 1992, in press
  • Shono T., Ohsawa K., Casida J. E. Metabolism of trans- and cis-permethrin, trans and cis-cypermethrin and decamethrin by microsomal enzymes. Journal of Agricultural and Food Chemistry 1979; 27(2)316–325
  • World Health Organization. Environmenal Health Criteria. Who, Geneva, 82. Cypermethrin

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