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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 7
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Research Article

Direct injection/h.p.l.c. methods for the analysis of drugs in biological samples

E. Doyle Department of Metabolism and Pharmacokinetics, SmithKline Beecham, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK
,
R. Huber Department of Metabolism, Byk Gulden Pharmaceuticals, D-7750, Konstance, Germany
&
V. S. Picot Department of Metabolism, Byk Gulden Pharmaceuticals, D-7750, Konstance, Germany; Department of Bioanalytical Sciences, Wellcome Research Laboratories, Kent, BR3 3BS, UK
Pages 765-774 | Received 05 Jun 1991, Accepted 27 Mar 1992, Published online: 22 Sep 2008

References

  • Currington A., Lewis V. A., Hills J. M., Picot V. S., Griffiths R. M&B 22 948, a specific cGMP phosphodiesterase inhibitor delays gastric emptying in rats. British Journal of Pharmacology 1989; 96: 267P
  • Doyle E., McDowall R. D., Murkitt G. S., Picot V. S., Rogers S. J. Two systems for the automated analysis of drugs in biological fluids using high-performance liquid chromatography. Journal of Chromatography 1990; 527: 56–77
  • Grundevik I., Jerndal G., Balmer K., Persson B-A. Fully automated gradient elution liquid chromatographic assay of omeprazole and two metabolites. Journal of Pharmaceutical and Biomedical Analysis 1986; 4: 389–398
  • Huber R., Zech K. Determination of drugs and their metabolites in biological samples by fully automated h.p.l.c. with on-line solid-liquid extraction and pre-column switching. Selective Sample Handling and Detection in h.p.l.c., R. W. Frei, K. Zech. Elsevier, Amsterdam 1988; 81–144
  • Huber R., Muller W., Banks M. C., Rogers S. J., Norwood P. C., Doyle E. High-performance liquid chromatographic determination of the H+/K+ ATPase inhibitor (BY 1023/SK&F 96022) and its sulphone metabolite in serum or plasma by direct injection and fully automated pre-column sample clean-up. Journal of Chromatography 1990; 529: 389–401
  • McDowall R. D. Sample preparation for biomedical analysis. Journal of Chromatography 1989; 492: 3–58
  • Nielsen H. Use of enzyme solubilization of tissues and direct injection on pre-columns of large volumes for analysing biological samples by high-performance liquid chromatography. Journal of Chromatography 1986; 381: 63–74
  • Picot V. S., Doyle E., Pearce J. C. Analysis of zaprinast in rat and human plasma by automated solid-phase extraction and reversed-phase high-performance liquid chromatography. Journal of Chromatography 1990; 527: 454–460
  • Plummer G. F. The automation of analytical methods for the determination of drugs in biological fluids. Advances in Laboratory Automation Robotics, J. R. Strimaitis, G. L. Hawk. Zymark Corporation, Hopkinton 1986; 47–70

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