Metabolism of calcium antagonist Ro 40-5967: a case history of the use of diode-array u.v. spectroscopy and thermospray-mass spectrometry in the elucidation of a complex metabolic pathway

H. R. Wiltshire Department of Pharmacokinetics and Metabolism, Roche Products Ltd., PO Box 8, Welwyn Garden City, Herts, AL7 3AY, UK

S. R. Harris Department of Pharmacokinetics and Metabolism, Roche Products Ltd., PO Box 8, Welwyn Garden City, Herts, AL7 3AY, UK

K. J. Prior Department of Pharmacokinetics and Metabolism, Roche Products Ltd., PO Box 8, Welwyn Garden City, Herts, AL7 3AY, UK

U. M. Kozlowski Department of Pharmacokinetics and Metabolism, Roche Products Ltd., PO Box 8, Welwyn Garden City, Herts, AL7 3AY, UK

E. Worth Department of Pharmacokinetics and Metabolism, Roche Products Ltd., PO Box 8, Welwyn Garden City, Herts, AL7 3AY, UK

References

Elvin A. T., Keenaghan J. B., Byrnes E. W., Tenthorey P. A., McMaster P. D., Takman B. H., Lalka D., Meyer M. B., Ronfield R. A. Tocainide conjugation in humans: novel biotransformation pathway for a primary amine. Journal of Pharmaceutical Sciences 1980; 69: 47–49
PubMed Web of Science ®Google Scholar
Leandri G., Mangini A., Montanari F., Passerini R. Ricerche sugli eterociclici: spettri di assortimento U.V. e proprietà cromoforiche—nota I: Imidazoli, benzimidazoli e fenilbenzimidazoli. Gazzetta Chimica Italiana 1955; 85: 769–794
Google Scholar
Schmitt R., Kleinbloesem C. H., Belz G. G. Ro 40–5967, a calcium antagonist of a new generation?. European Journal of Clinical Pharmacology 1989; 36(Suppl)A336
Google Scholar
Tremaine L. M., Strroh J. G., Ronfield R. A. Characterization of a carbamic ester glucuronide of the secondary amine sertraline. Drug Metabolism and Disposition 1989; 17: 58–63
PubMed Web of Science ®Google Scholar
Welker H. A., Eggers H., Kleinbloesem C., Erb K., Breithaupt K., Butzer R., Belz G. G. Ro 40–5967: pharmacokinetics of a new calcium antagonist. European Journal of Clinical Pharmacology 1989; 36(Suppl)A304
Google Scholar
v d Wildenberg H. M., Delbressine L. P. C., Kasperson F. M., Wagenaars G. N., Jacobs P. L. Biotransformation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino [4,5-c]pyrrolidine maleate in rats. Arzneimittel Forschung 1990; 40: 540–544
PubMed Web of Science ®Google Scholar

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Metabolism of calcium antagonist Ro 40-5967: a case history of the use of diode-array u.v. spectroscopy and thermospray-mass spectrometry in the elucidation of a complex metabolic pathway

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Metabolism of calcium antagonist Ro 40-5967: a case history of the use of diode-array u.v. spectroscopy and thermospray-mass spectrometry in the elucidation of a complex metabolic pathway

References

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date