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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 7
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Research Article

Measurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunteers

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Pages 859-869 | Received 10 Jun 1991, Accepted 06 Feb 1992, Published online: 22 Sep 2008

References

  • Aaltonen L., Allonen H., Iisalo E., Juhakoski A., Kleimola T., Sellman R. Antimuscarinic activity of oxybutynin in the human plasma quantitated by a radioreceptor assay. Acta Pharmacology et Toxicology 1984; 55: 100–103
  • Diokno A. C., Lapides J. Oxybutynin: a new drug with analgesic and anticholinergic properties. Journal of Urology 1972; 108: 307–309
  • Douchamps J., Derenne F., Stockis A., Gangji D., Juvent M., Herchuelz A. The pharmacokinetics of oxybutynin in man. European Journal of Clinical Pharmacology 1988; 35: 515–520
  • Farah F., Taylor W., Rawlins M. D., James O. Hepatic drug acetylation and oxidation: effects of ageing in man. British Medical Journal 1977; 2: 155–156
  • Fonda D. The prevalence and significance of dependent urinary incontinence. Australian and New Zealand Journal of Medicine 1989; 17: 600
  • Forbes G. B., Reina J. C. Adult lean body mass declines with age: some longitudinal observations. Metabolism 1970; 19: 653–663
  • Fredericks C. M., Anderson G. F., Kreulen D. J. A study of the anticholinergic and antispasmodic activity of oxybutynin (Ditropan) on rabbit detrusor. Investigative Urology 1975; 12: 317–319
  • Hallen B., Magnusson A., Bogentoft S., Ekelund P. Single and multiple dose pharmacokinetics of terodiline in geriatric patients. European Journal of Clinical Pharmacology 1988; 34: 291–297
  • Johnston A., Wollard R. C. STRIPE: an interactive computer program for the analysis of drug pharmacokinetics. Journal of Pharmacological Methods 1983; 9: 193–199
  • Lindeke B., Brotell H., Karlen B., Rietz G., Vietorisz A. Determination of oxybutynin (4-diethylaminobut-2-ynyl-2-cyclohexyl-2-phenyglycolate) in serum and urine by gas chromatography/mass spectrometry with single ion determination. Acta Pharmaceutica Suecica 1981; 18: 25–34
  • Lish P. M., Labudde J. A., Peters E. L., Robbins S. I. Oxybutynin—a musculotropic antispasmodic drug with moderate anticholinergic action. Archives Internationales de Pharmacodynamie et de Therapie 1965; 156: 467–488
  • Moisey C. U., Stephenson T. P., Brendler C. B. The urodynamic and subjective results of treatment of detrusor instability with oxybutynin chloride. British Journal of Urology 1980; 52: 472–475
  • Ouslander J. G., Blaustein J., Connor A., Orzeck S., Young, Chan-Loi. Pharmacokinetics and clinical effects of oxybutynin in geriatric patients. Journal of Urology 1988; 140: 47–50
  • Richey D. P., Bender A. D. Pharmacokinetic consequences of ageing. Annual Review of Pharmacology and Toxicology 1977; 17: 49–65
  • Rowe J. W., Andres R., Tobin J. D., Norris A. H., Shock N. W. The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. Journal of Gerontology 1976; 31: 155–163
  • Statistical Consultants Inc. PCNONLIN and NONLIN84, software for the statistical analysis of nonlinear models. The American Statistician 1986; 40(1)52
  • Thomas T. M., Plymat K. R., Blannin J., Meade T. W. Prevalence of urinary incontinence. British Medical Journal 1980; 281: 1243–1245
  • Westlin L. Anticholinergic effects of two metabolites of oxybutynin. Smith & Nephew Pharmaceuticals Ltd. 1985, Research Report No. 840625F., Data on file

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