Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 11
16
Views
8
CrossRef citations to date
0
Altmetric
Miscellaneous Article

The metabolism of acitretin and isoacitretin in the in situ isolated perfused rat liver

, , , &
Pages 1229-1237 | Received 01 Apr 1992, Accepted 30 Apr 1992, Published online: 23 Apr 2010

References

  • Avigan J., Steinberg D., Gutman A. Alpha-decarboxylation, an important pathway for degradation of phytanic acid in animals. Biochemical and Biophysical Research Communications 1966; 24: 838–844
  • Bornemann L. D., Cotler S., Khoo K. C., Carbone J. J., Colborn W. A. Effect of the route of administration on the pharmacokinetics of etretinate in the dog. Biopharmaceutics and Drug Disposition 1988; 9: 119–126
  • Brindley C. J. Overview of recent clinical pharmacokinetic studies with acitretin (Ro 10–1670, Etretin). Dermatologia 1989; 178: 79–87
  • Cotler S., Bugge C. L. J., Colburn W. A. Role of gut contents, intestinal wall, and liver on the first pass metabolism and absolute bioavailability of isotretinoin in the dog. Drug Metabolism and Disposition 1983; 11: 458–462
  • Cotler S., Chen S., Macasieb T., Colburn W. A. Effect of route administration and biliary excretion on the pharmacokinetics of isotretinoin in the dog. Drug Metabolism and Disposition 1984; 12: 143–147
  • Cullum M. E., Zile M. H. The metabolism of all-trans retinoic acid and all-trans retinyl acetate. Journal of Biological Chemistry 1985; 260: 10590–10596
  • Geiger J. M., Brindley C. J. Cis-trans interconversion of acitretin in man. Skin Pharmacology 1988; 1: 230–236
  • Jewell R. C., McNamara P. J. Glutathione catalysis of interconversion of acitretin and its 13-cis isomer, isoacitretin. Journal of Pharmaceutical Science 1990; 79: 444–446
  • Massarella J., Vane F., Bugge C., Rodriguez L., Cunningham W. J., Franz T., Colburn C. Etretinate kinetics during chronic dosing in severe psoriasis. Clinical Pharmacology and Therapeutics 1985; 37: 439–466
  • McNamara P. J., Blouin R. A. Pharmacokinetic profile of two aromatic retinoids (etretinate and acitretin) in the obese Zucker rat. Journal of Pharmaceutical Science 1990; 79: 301–304
  • McNamara P. J., Jewell R. C., Jensen B. K., Brindley C. J. Food increases the bioavailability of acitretin. Journal of Clinical Pharmacology 1988; 28: 1051–1055
  • Nankevis R., Cheema M. S., Davis S. S., Day M. H., Shaw I. P. N. Pharmacokinetics of isotretinoin in the anesthetized rat following intravenous administration of an emulsion. Journal of Pharmacy and Pharmacology 1990; 40S: 35P
  • Pang K. S., Gillette J. R. Kinetics of metabolite formation and elimination in the perfused rat liver prepration: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin. Journal of Pharmacology and Experimental Therapeutics 1978; 207: 178–194
  • Pang K. S., Huang J. C., Finkle C., Kong P., Cherry W. F., Fayz S. Kinetics of procainamide N-acetylation in the rat in-vivo and in the perfused rat liver preparation. Drug Metabolism and Disposition 1984; 12: 314–322
  • Swanson B. N., Frolik C. A., Zaharevity D. W., Roller P. R., Sporn M. B. Dose-dependent kinetics of all-trans-retinoic acid in rats. Biochemical Pharmacology 1981; 30: 107–113
  • Teelmann K., Bollag W. The relevance of the mouse papilloma test as a predictor of retinoid activity in human psoriasis. Dermatologia 1990; 180: 30–35
  • Vane F. M., Bugge C. L. J., Rodriguez L. C. Identification of etretinate metabolites in human blood. Drug Metabolism and Disposition 1989; 17: 280–285
  • Zile M. H., Inhorn R. C., DeLuca H. F. Metabolism in vivo of all-trans retinoic acid. Journal of Biological Chemistry 1982; 2576: 3544–3550

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.