Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 11
Submit an article Journal homepage
18
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Effects of oxygen concentration on the metabolism of anisole homologues by rat liver microsomes

H. Ohi Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113, Japan
,
E. Takahara Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113, Japan
,
S. Ohta Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113, Japan
&
M. Hirobe Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113, Japan
Pages 1329-1337 | Received 16 Dec 1991, Accepted 22 May 1992, Published online: 23 Apr 2010

References

  • Angus P. W., Morgan D. J., Smallwood R. A. Hypoxia and hepatic drug metabolism—clinical implications. Alimental Pharmacology and Therapeutics 1990; 4: 213–225
  • Aw T. Y., Jones D. P. Secondary bioenergetic hypoxia: Inhibition of sulfation and glucuronidation reactions in isolated hepatocytes at low O2 concentration. Journal of Biological Chemistry 1982; 257: 8997–9004
  • Bernhardt F. H., Erdin N., Staudinger H., Ulrich V. Interactions of substrates with a purified 4-methoxybenzoate monooxygenase system (O-demethylation) from Pseudomonas putida. European Journal of Biochemistry 1973; 35: 126–134
  • Boyd G. S. Mixed-function oxidation. Biochemical Journal 1970; 117: 16P–18P
  • Daly J. Metabolism of acetanilides and anisole with rat liver microsomes. Biochemical Pharmacology 1970; 19: 2979–2993
  • Daly J., Jerina D., Witkop B. Migration of deuterium during hydroxylation of aromatic substrates by liver microsomes. I. Influence of ring substituents. Archives of Biochemistry and Biophysics 1968; 128: 517–527
  • Erickson R. R., Yu-Dent P., Holtzman J. L. The kinetics of ethylmorphine N-demethylation in isolated hepatocytes. The effect of drug transport and oxygen concentration. Journal of Pharmacology and Experimental Therapeutics 1982; 220: 35–38
  • Fujii M., Morio M., Kikuchi H. A possible role of cytochrome P450 in anaerobic dehalogenation of halothane. Biochemical and Biophysical Research Communications 1981; 101: 1158–1163
  • Hlavica P., Kiese M. N-Oxygenation of N-alkyl- and N,N-dialkylanilines by rabbit liver microsomes. Biochemical Pharmacology 1969; 18: 1501–1509
  • Holtzman J. L., Gander J. E., Erickson R. R. The effect of NADH and low oxygen pressure on the hepatic microsomal ethylmorphine N-demethylase activity of the male rat. Journal of Biological Chemistry 1983; 258: 5400–5404
  • Jones D. P. Hypoxia and drug metabolism. Biochemical Pharmacology 1981; 30: 1019–1023
  • Jones D. P. Benzylamine metabolism at low O2 concentrations: relative sensitivities of monoamine oxidase, aldehyde dehydrogenase and hippurate synthesis to hypoxia. Biochemical Pharmacology 1984; 33: 413–417
  • Jones D. P., Mason H. G. Gradients of O2 concentration in hepatocytes. Journal of Biological Chemistry 1978; 253: 4874–4880
  • Kessler M., Long H., Sinagowitz E., Rink R., Höper J. Homeostasis of oxygen supply in liver and kidney. Oxygen Transport to Tissue, D. F. Bruley, H. I. Bicher. Plenum Press, New York 1973; 351–360
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Lu A. Y. H., West S. B. Multiplicity of mammalian microsomal cytochrome P-450. Pharmacological Reviews 1980; 31: 277–295
  • Pohl L. R., Schulick R. D., Highet R. J., George J. W. Reductive oxygenation mechanism of metabolism of carbon tetrachloride to phosgene by cytochrome P-450. Molecular Pharmacology 1984; 25: 318–321
  • Smith B. R., Born J. L., Garcia D. J. Influence of hypoxia on the metabolism and excretion of misonidazole by the isolated perfused rat liver—a model system. Biochemical Pharmacology 1983; 32: 1609–1612
  • Takahara E., Ohta S., Hirobe M. Effect of oxygen concentration on the metabolic pathway of anisole in rat liver microsomes. Biochemical Pharmacology 1986; 35: 541–544
  • Tomasi A., Albano E., Botti B., Slater T. F., Vannini V. Free radical intermediates under hypoxic conditions in the metabolism of halogenated carcinogens. Toxicology and Pathology 1984; 12: 240–246
  • Tsuru M., Erickson R. R., Holtzman J. L. The metabolism of phenytoin by isolated hepatocytes and hepatic microsomes from male rats. Journal of Pharmacology and Experimental Therapeutics 1982; 222: 658–661
  • Von Kérekjártó B., Staudinger H. Die Sauerstoffabhangigkeit der Hydroxylierung von Acetanilid zu 4-Acetamino-phenol durch Kenichenlebermikrosomes. Hoppe-Seyler's Zeitschrift fúr Physiologische Chemie 1966; 347: 7–17
  • Webster L. K., Jones D. B., Mihaly G. W., Morgan D. J., Smallwood R. A. Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver. Biochemical Pharmacology 1985; 34: 1239–1245
  • Zachariah P. K., Juchau M. R. Inhibition of human placental mixed-function oxidations with carbon monoxide: reversal with monochromatic light. Journal of Steroid Biochemistry 1977; 8: 221–228

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.