Metabolism of methapyrilene by Fischer-344 rat and B₆C₃F₁ mouse hepatocytes

References

• Althaus F. R., Lawrence S. D., Sattler G. L., Pitot H. C. DNA damage induced by the antihistaminic drug methapyrilene hydrochloride. Mutation Research 1982; 103: 213–218
   PubMed Web of Science ®Google Scholar
• Blazak W. F., Stewart B. E., Galperin I., Allen K. L., Rudd C. J., Mitchell A. D., Caspary W. J. Chromosome analysis of trifluorothymidine-resistant L5178Y mouse lymphoma cell colonies. Environmental Mutagenesis 1986; 8: 229–240
   PubMedGoogle Scholar
• Brennan L. M., Creasia D. A. The effects of methapyrilene hydrochloride on hepatocarcinogenicity and phenobarbital-induced sleeping time in rats and mice. Toxicology and Applied Pharmacology 1982; 66: 252–258
   PubMed Web of Science ®Google Scholar
• Budroe J. D., Shaddock J. G., Casciano D. A. A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay. Mutation Research 1984; 135: 131–137
   PubMed Web of Science ®Google Scholar
• Casciano D. A., Schol H. M. Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay. Cancer Letters 1984; 21: 337–341
   PubMed Web of Science ®Google Scholar
• Casciano D. A., Shaddock J. G., Talaska G. The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats. Mutation Research 1988; 208: 129–135
   PubMed Web of Science ®Google Scholar
• Cerniglia C. E., Hansen E. B., Jr, Lambert K. J., Korfmacher W. A., Miller D. W. Fungal transformations of the antihistamines: metabolism of methapyrilene, thenyldiamine and tripelennamine to N-oxide and N-demethylated derivatives. Xenobiotica 1988; 18: 301–312
   PubMed Web of Science ®Google Scholar
• Douglas W. W. Histamine and 5-hydroxytryptamine (serotonin) and their antagonists. The Pharmacological Basis of Therapeutics, A. G. Gilman, L. S. Goodman, A. Gilman. Macmillan, New York, NY 1980; 609–646, Chapter 26
   Google Scholar
• Glauert H. P., Pitot H. C. Effect of the antihistamine, methapyrilene, as an initiator of hepatocarcinogenesis in female rats. Cancer Letters 1989; 46: 189–194
   PubMed Web of Science ®Google Scholar
• Habs M., Shubik P., Eisenbrand G. Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague Dawley rats. Journal of Cancer Research and Clinical Oncology 1986; 111: 71–74
   PubMed Web of Science ®Google Scholar
• Kammerer R. C., Schmitz D. A. Metabolism of methapyrilene by rat-liver homogenate. Xenobiotica 1986; 16: 671–680
   PubMed Web of Science ®Google Scholar
• Kammerer R. C., Schmitz D. A. Species differences in the in vitro metabolism of methapyrilene. Xenobiotica 1987; 17: 1121–1130
   PubMed Web of Science ®Google Scholar
• Kammerer R. C., Froines J. R., Price T. Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation. Food and Chemical Toxicology 1986; 24: 981–985
   PubMed Web of Science ®Google Scholar
• Kammerer R. C., Schmitz D. A., Lampe M. A., Kloc K. The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat. Xenobiotica 1988; 18: 869–881
   PubMed Web of Science ®Google Scholar
• Kelly D. W., Slikker W., Jr. The metabolism and elimination of pyrilamine maleate in the rat. Drug Metabolism and Disposition 1987; 15: 460–465
   PubMed Web of Science ®Google Scholar
• Kelly D. W., Holder C. L., Korfmacher W. A., Slikker W., Jr. Plasma elimination and urinary excretion of methapyrilene in the rat. Drug Metabolism and Disposition 1990; 18: 1018–1024
   PubMed Web of Science ®Google Scholar
• Korfmacher W. A., Holder C. L., Cerniglia C. E., Miller D. W., Hansen E. B., Jr, Lambert K. L., Gosnell A. B., Slikker W., Jr, Rushing L. G., Thompson H. C., Jr. Desorption chemical ionization mass spectrometry of nine antihistamines and some of their metabolites. Spectroscopy: An International Journal 1985; 4: 181–192
   Google Scholar
• Lampe M. A., Kammerer R. C. Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro. Carcinogenesis 1987; 8: 1525–1529
   PubMed Web of Science ®Google Scholar
• Lay J. O., Jr, Korfmacher W. A., Miller D. W., Siitonen P., Holder C. L., Gosnell A. B. Desorption chemical ionization and fast atom bombardment mass spectrometric studies of the glucuronide metabolites of doxylamine. Biomedical and Environmental Mass Spectrometry 1986; 13: 627–632
   PubMedGoogle Scholar
• Lay J. O., Jr, Getek T. A., Kelly D. W., Slikker W., Jr, Korfmacher W. A. Fast-atom bombardment and thermospray mass spectrometry for the characterization of two glucuronide metabolites of methapyrilene. Rapid Communications in Mass Spectrometry 1989a; 3: 72–75
   PubMedGoogle Scholar
• Lay J. O., Jr, Holder C. L., Cooper W. M. Characterization of seven antihistamines, their N-oxides and related metabolites by fast atom bombardment mass spectrometry and fast atom bombardment tandem mass spectrometry. Biomedical and Environmental Mass Spectrometry 1989b; 18: 157–167
   PubMedGoogle Scholar
• Lijinsky W. Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats. Food and Chemical Toxicology 1984; 22: 27–30
   PubMed Web of Science ®Google Scholar
• Lijinsky W., Knutsen G., Reuber M. D. Failure of methapyrilene to induce tumors in hamsters and guinea pigs. Journal of Toxicology and Environmental Health 1983; 12: 653–657
   PubMed Web of Science ®Google Scholar
• Lijinsky W., Reuber M. D., Blackwell B. N. Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride. Science 1980; 209: 817–819
   PubMed Web of Science ®Google Scholar
• McQueen C. A., Williams G. M. Characterization of DNA repair elicited by carcinogens and drugs in the hepatocyte primary culture/DNA repair test. Journal of Toxicology and Environmental Health 1981; 8: 463–477
   PubMed Web of Science ®Google Scholar
• Oberly T. J., Bewsey B. J., Probst G. S. An evaluation of the L5178Y TK +/− mouse lymphoma forward mutation assay using 42 chemicals. Mutation Research 1984; 125: 291–306
   PubMed Web of Science ®Google Scholar
• Oldham J. W., Casciano D. A., Farr J. A. The isolation and primary culture of viable, nonproliferating rat hepatocytes. Tissue Culture Association Manual 1979; 5: 1047–1050
   Google Scholar
• Probst G. S., Neal S. B. The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures. Cancer Letters 1980; 10: 67–73
   PubMed Web of Science ®Google Scholar
• Singer S. S., Lijinsky W., Kratz L. E., Castagnoli N., Jr, Rose J. E. A comparison of in vivo and in vitro metabolites of the H1-antagonist N,N-dimethyl-N'-2-pyridyl-N'-(2-thienylmethyl)-1,2-ethanediamine (methapyrilene) in the rat. Xenobiotica 1987; 17: 1279–1291
   PubMed Web of Science ®Google Scholar
• Steinmetz K. L., Tyson C. K., Meierhenry E. F., Spalding J. W., Mirsalis J. C. Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene. Carcinogenesis 1988; 9: 959–963
   PubMed Web of Science ®Google Scholar
• Turner N. T., Woolley J. L., Jr., Hozier J. C., Sawyer J. R., Clive D. Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y TK +/− mouse lymphoma assay. Mutation Research 1987; 189: 285–297
   PubMed Web of Science ®Google Scholar
• Ziegler R., Ho B., Castagnoli N., Jr. Trapping of metabolically generated electrophilic species with cyanide ion: metabolism of methapyrilene. Journal of Medicinal Chemistry 1981; 24: 1133–1138
   PubMed Web of Science ®Google Scholar