Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 12
20
Views
32
CrossRef citations to date
0
Altmetric
Research Article

Induction of rat hepatic mixed-function oxidases by acetone and other physiological ketones: Their role in diabetes-induced changes in cytochrome P450 proteins

, , , &
Pages 1441-1450 | Received 14 Mar 1992, Accepted 24 Jul 1992, Published online: 22 Sep 2008

References

  • Ayrton A. D., Ioannides C., Parke D. V. Induction of the cytochrome P450I and IV families and peroxisome proliferation in the liver of rats treated with benoxaprofen. Biochemical Pharmacology 1991; 42: 109–115
  • Barnett C. R., Flatt P. R., Ioannides C. Role of ketone bodies in the diabetes-induced changes in hepatic mixed-function oxidase activities. Biochimica et Biophysica Acta 1988; 967: 250–254
  • Barnett C. R., Flatt P. R., Ioannides C. Induction of hepatic microsomal P450I and IIB proteins by hyperketonaemia. Biochemical Pharmacology 1990a; 40: 393–397
  • Barnett C. R., Gibson G. G., Wolf C. R., Flatt P. R., Ioannides C. Induction of cytochrome P450III and P450IV family proteins in streptozotocin-induced diabetes. Biochemical Journal 1990b; 268: 765–769
  • Barnett C. R., Flatt P. R., Ioannides C. Hyperketonaemia markedly modulates the metabolic activation of chemical carcinogens. Chemico-Biological Interactions 1990c; 74: 281–289
  • Bellward G. D., Chang T., Rodrigues B., McNeill J. H., Maines S., Ryan D. E., Levin W., Thomas P. E. Hepatic cytochrome P-450j induction in the spontaneously diabetic BB rat. Molecular Pharmacology 1988; 33: 140–143
  • Burke M. D., Mayer R. T. Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metabolism and Disposition 1974; 2: 583–588
  • Chopra I. J., Wiersinga W., Frank H. Alterations in hepatic monoiodination of iodothyronines in the diabetic rat. Life Sciences 1981; 28: 1765–1776
  • Dunn F. L. Hyperlipidaemia in diabetes mellitus. Diabetes/Metabolism Reviews 1990; 6: 47–61
  • Favreau L. V., Schenkman J. B. Cytochrome P-450 alterations in the BB/Wor spontaneously diabetic rat. Biochemical Pharmacology 1988; 37: 3505–3509
  • Flatt P. R., Bass S. L., Ayrton A. D., Trinick J., Ioannides C. Metabolic activation of chemical carcinogens by hepatic preparations from streptozotocin-treated rats. Diabetologia 1989; 32: 135–139
  • Hanasono G. K., Witschi H., Plaa G. L. Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats. Proceedings of the Society of Experimental Biology and Medicine 1975; 149: 903–907
  • Hewitt W. R., Plaa G. L. Potentiation of carbon tetrachloride-induced hepatotoxicity by 1,3-butanediol. Toxicology and Applied Pharmacology 1979; 47: 177–180
  • Hewitt W. R., Miyajima H., Côte M. G., Plaa G. L. Modification of haloalkane-induced hepatotoxicity by exogenous ketones and metabolic ketosis. Federation Proceedings 1980; 39: 3118–3123
  • Ioannides C. Metabolism and toxicity of chemicals in diabetes. Acta Pharmaceutica Jugoslavica 1990; 40: 423–429
  • Ioannides C., Parke D. V. Mechanism of induction hepatic microsomal drug metabolising enzymes by a series of barbiturates. Journal of Pharmacy and Pharmacology 1975; 27: 739–746
  • Ioannides C., Bass S. L., Ayrton A. D., Trinick J., Walker R. W., Flatt P. R. Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens. Chemico-Biological Interactions 1988; 68: 189–202
  • Johansson I., Ekstrom G., Scholte B., Puzycki D., Jornvall H., Ingelman-Sundberg M. Ethanol-, fasting- and acetone-inducible cytochromes P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. Biochemistry 1988; 27: 1925–1931
  • Koop D. R., Crump B. L., Nordblom G. D., Coon M. J. Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole and isoniazid. Proceedings of the National Academy of Sciences, USA 1985; 82: 4065–4069
  • Koop D. R., Leathem C. L., Tierney D. J. The utility of p-nitrophenol hydroxylation in P450IIE1 analysis. Drug Metabolism Reviews 1989; 20: 541–551
  • Laemmli U. K. Cleavage of structural proteins during the assembly of the head bacteriophage T4. Nature 1970; 227: 680–685
  • Lemoine A., Marie S., Cresteil T. Expression of cytochrome P-450 isozymes in the liver of hypophysectomised rats. European Journal of Biochemistry 1988; 177: 597–604
  • Lowry O. H., Rosebrough N.-J., Parr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Lu A. Y. H., Kuntzman R., West S., Jacobson M., Conney A. H. Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylation. Journal of Biological Chemistry 1972; 247: 1727–1734
  • Lubet R. A., Mayer R. T., Cameron J. W., Nims R. W., Burke M. D., Wolff T., Guengerich F. P. Dealkylation of pentoxy resorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat. Archives of Biochemistry and Biophysics 1985; 238: 43–48
  • McGarry J. D., Guest M. J., Foster D. W. Ketone body metabolism in the ketosis of starvation and alloxan diabetes. Journal of Biological Chemistry 1970; 245: 4382–4390
  • Meehan R. R., Forrester L. M., Stevenson K., Hastie N. D., Buchmann A., Kunz H. W., Wolf C. R. Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy. Biochemical Journal 1988; 254: 789–797
  • Mehlman M. A., Tobin R. B., Mackerer C. R. 1,3-Butanediol catabolism in the rat. Federation Proceedings 1975; 34: 2182–2185
  • Murray F. T., Orth J., Gunsalus G., Weisz J., Li J. R., Jefferson L. S., Musto N. A., Bardin C. W. The pituitary-testicular axis in the streptozotocin diabetic male rat: evidence for gonadotroph, Sertoli cell and Leydig cell dysfunction. International Journal of Andrology 1981; 4: 265–286
  • Omura T., Sato R. The carbon monoxide pigment of liver microsomes. I. Evidence for its haemoprotein nature. Journal of Biological Chemistry 1964; 239: 2370–2378
  • Parker G. L., Orton T. C. Induction by oxyisobutyrates of hepatic and kidney microsomal cytochrome P-450 with specificity towards hydroxylation of fatty acids. Biochemistry, Biophysics and Regulation of Cytochrome P-450, J. A. Gustafsson, J. Carlstedt-Duke, A. Mode, J. Raffer. Elsevier/North Holland, Amsterdam 1980; 373–377
  • Past M. R., Cook D. E. Effects of diabetes on rat liver cytochrome P-450. Biochemical Pharmacology 1982; 31: 3329–3334
  • Past M. R., Cook D. E. Catalytic activities of cytochrome P-450 from female rat liver: correlation with sex differences in drug metabolism is diabetic liver. Research Communications in Chemical Pathology and Pharmacology 1983; 40: 379–390
  • Phillipson C. E., Godden P. M. M., Lum P. Y., Ioannides C., Parke D. V. Determination of cytochrome P-448 activity in biological tissues. Biochemical Journal 1984; 221: 81–88
  • Reinke L. A., Moyer M. J. p-Nitrophenol hydroxylation: a microsomal oxidation which is highly inducible by ethanol. Drug Metabolism and Disposition 1985; 13: 548–552
  • Rodrigues A. D., Gibson G. G., Ioannides C., Parke D. V. Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins. Biochemical Pharmacology 1987; 36: 4277–4281
  • Serri O., Brazeau B. Growth hormone responsiveness in vivo and in vitro to growth hormone releasing factor in the spontaneously diabetic BB Wistar rat. Neuroendocrinology 1987; 46: 162–166
  • Song B.-J., Gelboin H. V., Park S.-S., Yang C. S., Gonzalez F. J. Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Journal of Biological Chemistry 1986; 261: 16689–16697
  • Stevens J. Determination of glucose by an automatic analyser. Journal of Clinica and Chimica Acta 1971; 32: 199–201
  • Tamburini P., Masson H. A., Bains S. K., Makowski R. J., Morris B., Gibson G. G. Multiple forms of hepatic cytochrome P-450: Purification, characterisation and comparison of a novel clofibrate-induced isozyme with other major forms of cytochrome P-450. European Journal of Biochemistry 1984; 139: 235–246
  • Tannenbaum G. S. Growth hormone secretory dynamics in streptozotocin diabetes: evidence of a role for endogenous circulating somatostatin. Endocrinology 1981; 108: 76–82
  • Thomas P. E., Bandiera S., Maines S. L., Ryan D. E., Levin W. Regulation of cytochrome P-450j, a high affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes. Biochemistry 1987; 26: 2280–2289
  • Thummel K. E., Schenkman J. B. Effects of testosterone and growth hormone treatment in the diabetic rat. Molecular Pharmacology 1990; 37: 119–129
  • Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences, USA 1979; 76: 4350–4355
  • Watkins J. B., III, Sanders R. A., Beck L. V. The effect of long-term streptozotocin-induced diabetes on the hepatotoxicity of bromobenzene and carbon tetrachloride and hepatic biotransformation in rats. Toxicology and Applied Pharmacology 1988; 93: 329–338
  • Williams C. H., Jr, Kamin H. Microsomal triphosphopyridine cytochrome c reductase of liver. Journal of Biological Chemistry 1962; 237: 587–595
  • Wrighton S. A., Maurel P., Schultz E. G., Watkins P. B., Young B., Guzelian P. S. Identification of the cytochrome P-450 induced by macrolide antibiotics in the rat liver as the glucorcorticoid responsive cytochrome P-450p. Biochemistry 1985; 24: 2171–2178
  • Yamazoe Y., Abu-Zeid M., Yamauchi K., Murayama N., Shimada M., Kato R. Enhancement by alloxan-induced diabetes of the rate of metabolic activation of three pyrolysate carcinogens via increase in the P-448H content in rat liver. Biochemical Pharmacology 1988a; 37: 2503–2506
  • Yamazoe Y., Shimada M., Murayama N., Yamauchi K., Kato R. Alteration of hepatic drug metabolising activities and contents of cytochrome P-450 isozymes by neonatal monosodium glutamate treatment. Biochemical Pharmacology 1988b; 37: 1687–1691
  • Yamazoe Y., Murayama N., Shimada M., Yamauchi K., Kato R. Cytochrome P-450 in livers of diabetic rats. Regulation by growth hormone and insulin. Archives of Biochemistry and Biophysics 1989; 268: 567–575

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.