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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 4
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Research Article

Urinary metabolites of pinacidil: I. isolation and identification of the metabolites in rat urine

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Pages 391-400 | Received 26 Jul 1992, Accepted 24 Nov 1992, Published online: 22 Sep 2008

References

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  • Brewster K., Harrison J. M., Leadbeater L., Newman J., Upshall D. G. The fate of 2-chlorobenzylidene malononitrile (CS) in rats. Xenobiotica 1987; 17: 911–924
  • De Long A. F., Oldham S. W., De Sante K. A., Nell G., Henry D. P. Disposition of [14C]pinacidil in humans. Journal of Pharmaceutical Sciences 1988; 77: 153–156
  • Eilertsen E., Magnussen M. P., Petersen H. J., Rastrup-Andersen N., Srensen H., Arrigoni-Martelli E. Metabolism of the new antihypertensive agent pinacidil in rat, dog and man. Xenobiotica 1982; 12: 187–196
  • Kardel T., Hilden T., Carlsen J., Trap-Jensen J. N-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine, a new vasodilating agent: acute effect on blood pressure and pharmacokinetics in hypertensive patients. Journal of Cardiovascular Pharmacology 1981; 3: 1002–1007
  • Petersen H. J., Nielsen C. K., Arrigoni-Martelli E. Synthesis and hypotensive activity ofN-alkyl-N'-cyano-N-pyridylguanidines. Journal of Medicinal Chemistry 1978; 21: 773–781
  • Weston A. H., Bray K. M., Duty S., Mcharg A. D., Newgreen D. T., Southerton J. S. In vitro studies on the mode of action of pinacidil. Drugs 1988; 36: 10–28

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