References
- Caccia S., Confalonieri S., Guiso G., Celeste S., Marini P. P. Liquid chromatography of the potential memory-enhancing agent CL 275,838 and its main metabolites, using a post-column photochemical reactor and fluorimetric detection. Journal of Chromatography 1992; 581: 109–117
- Caccia S., Confalonieri S., Guiso G., Lucca U., Parma E., Guido M., Tettamanti M., Tiraboschi P., Spagnoli A. Single-dose safety and pharmacokinetics of a potential cognition-enhancing compound, CL 275,838, in healthy volunteers. Journal of Clinical Pharmacology 1993, in press
- Caccia S., Garattini S. Formation of active metabolites of psychotropic drugs. An updated review of their significance. Clinical Pharmacokinetics 1990; 18: 434–459
- Cinti D. L., Moldeu'S P., Schenkman J. B. Kinetic parameters of drug metabolizing enzymes in Ca2+ -sedimented microsomes from rat liver. Biochemical Pharmacology 1972; 21: 3249–3256
- Confalonieri S., Cosmi G., Guiso G., Gherardi S., Guido M., Caccia S. The pharmacokinetics of a potential memory-enhancing compound, CL 275,838, in fasted and fed volunteers. Drug Investigation 1992; 4: 322–328
- Eishourbagy N. A., Guzelian P. S. Separation, purification, and characterization of a novel form a hepatic cytochrome P450 from rats treated with pregnenolone-16α-carbonitrile. Journal of Biological Chemistry 1980; 255: 1279–1285
- Gonzales F. G. The molecular biology of cytochrome P450s. Pharmacological Reviews 1989; 40: 243–288
- Guiso G., Confalonieri S., Caccia S. High-performance liquid chromatographic method for the determination of a potential memory-enhancing compound (CL 275,838) and its desbenzyl metabolite in rat plasma and serum. Journal of Chromatography 1991; 572: 346–351
- Guiso G., Confalinieri S., Caccia S., Kelly R. G. Post-column derivatization and fluorimetric detection for the liquid chromatographic analysis of the potential memory-enhancing agent CL 275,838 in human plasma. II Farmaco 1992; 47: 1215–1223
- Guengerich F. P., Dannan G. A., Wright S. T., Martin M. V., Kaminsky L. S. Purification and characterization of liver microsomal cytochromes P450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital of β-naphthoflavone. Biochemistry 1982; 21: 6019–6030
- Ioannides C., Parke D. V. The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metabolism Reviews 1990; 22: 1–85
- Kamataki T., Maeda K., Yamazoe Y., Nagai T., Kato R. Sex difference of cytochrome P450 in the rat: purification, characterization, and quantitation of constitutive forms of cytochrome P450 from liver microsomes of male and female rats. Archives of Biochemistry and Biophysics 1983; 225: 758–770
- Kato R., Kamataki T. Cytochrome P450 as a determinant of sex differences of drug metabolism in the rat. Xenobiotica 1982; 12: 787–800
- Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
- Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry 1964; 239: 2370–2378
- Samanin R., Carli M., Cervo L., Vezzani A., Mennini T. CL 275,838, a novel compound showing antidepressant activity and beneficial effects of memory deficits in the rat. Society for Neuroscience Abstracts 1991; 17(2)1587
- Soucek P., Gut I. Cytochromes P450 in rats: structures, functions, properties and relevant human forms. Xenobiotica 1992; 22: 83–103
- Sugiura M., Iwasaki K., Noguchi H., Kato R. Evidence for the involvement of cytochrome P450 in tiaramide N-oxide reduction. Life Sciences 1974; 15: 1433–1442
- Waxman D. J. Regulation of rat hepatic cytochrome P450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes. Biochemistry 1985; 24: 4409–4417