Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 1
11
Views
4
CrossRef citations to date
0
Altmetric
Research Article

The metabolism of piperidine-type phenothiazine antipsychotic agents. II. Sulforidazine in dog and human

, , , , &
Pages 27-36 | Received 03 Feb 1992, Accepted 28 Aug 1992, Published online: 22 Sep 2008

References

  • Axelsson R. On the serum concentrations and antipsychotic effects of thioridazine, thioridazine side-chain sulfoxide and thioridazine side-chain sulfone, in chronic psychotic patients. Current Therapeutic Research 1977; 21: 587–605
  • Eap C. B., Souche A., Koeb L., Baumann P. Light-induced racemization: Artifacts in the analysis of the diastereoisomeric pairs of thioridazine 5-sulfoxide in the plasma and urine of patients treated with thioridazine. Therapeutic Drug Monitoring 1991; 13: 356–362
  • Ganes D. A., Midha K. K. Sensitive and specific high-performance liquid chromatographic assay for the quantification of sulforidazine and two diastereomeric sulforidazine-5-sulfoxide metabolites in plasma. Journal of Chromatography 1987; 423: 227–237
  • Hale P. W., Jr., Poklis A. Thioridazine 5-sulfoxide diastereoisomers in serum and urine from rats and man after chronic thioridazine administration. Journal of Analytical Toxicology 1985; 9: 197–201
  • Hall K., Yeung P. K. F., Midha K. K. Decomposition of sulphoxide metabolites of phenothiazine antipsychotics during gas chromatographic analysis. Journal of Chromatography 1982; 231: 200–204
  • Jaworski T. J., Sardessai M. S., Aravagiri M., Lin G., Shi Y. Y., Hawes E. M., Hubbard Mc J. W., Kay G., Midha K. K. Synthesis of the N-oxides of phenothiazine antipsychotic agents. Journal of Pharmaceutical Sciences 1993, in press
  • Jorgensen A. Metabolism and pharmacokinetics of antipsychotic drugs. Progress in Drug Metabolism, J. W. Bridges, L. F. Chasseaud. Taylor & Francis, London 1986; Vol. 9: 111–174
  • Lin G., Midha K. K., Hawes E. M. Synthesis of the piperidinone metabolites of piperidine type phenothiazine antipsychotic drugs via ruthenium tetroxide oxidation. Journal of Heterocyclic Chemistry 1991; 28: 215–219
  • Lin G., Hawes Mc E. M., Kay G., Midha K. K. The metabolism of piperidine-type phenothiazine antipsychotic agents. I. Sulforidazine in the rat. Xenobiotica 1992; 22: 303–317
  • Midha K. K., Jaworski T. J., Hawes Mc E. M., Kay G., Hubbard J. W., Aravagiri M., Marder S. R. Radioimmunoassay and other methods for trace analysis of N-oxide compounds. N-oxidation of Drugs: Biochemistry, Pharmacology, Toxicology, P. Hlavica, L. A. Damani. Chapman & Hall, London 1991; 37–55
  • Mills G. A., Walker V., Clench M. R., Parr V. C. Analysis of urinary organic acids by plasmaspray™ liquid chromatography/mass spectrometry. Biomedical Environmental Mass Spectrometry 1988; 16: 259–261
  • Mohammad T., Midha K. K., Hawes E. M. Synthesis of deuterium labelled analogues of S-oxidative metabolites of thioridazine. Journal of Labelled Compounds and Radiopharmaceuticals 1989; 27: 181–188
  • Papadopoulos A. S., Crammer J. L. Sulphoxide metabolites of thioridazine in man. Xenobiotica 1986; 16: 1097–1107
  • Papadopoulos A. S., Crammer J. L., Cowan D. A. Phenolic metabolites of thioridazine in man. Xenobiotica 1985; 15: 309–316
  • Poklis A., Wells C. E., Juenge E. C. Thioridazine and its metabolites in post mortem blood, including two stereoisomeric ring sulfoxides. Journal of Analytical Toxicology 1982; 6: 250–252
  • Renwick A. G. Sulphoxides and sulphones. Sulphur-containing Drugs and Related Organic Compounds: Chemistry, Biochemistry and Toxicology, L. A. Damani. Ellis Horwood, Chichester 1989; Vol. 1: 133–154, part B
  • Shindo N., Yamauchi N., Murayama K., Fairbrother A., Krolik S. Identification of 17-hydroxyprogesterone and other steroid hormones in saliva from a normal child and patients with congenital adrenal hyperplasia by plasmaspray liquid chromatography/mass spectrometry. Biomedical Chromatography 1990; 4: 171–174
  • Watkins G. M., Whelpton R., Buckley D. G., Curry S. H. Chromatographic separation of thioridazine sulphoxide and N-oxide diastereoisomers: identification as metabolites in the rat. Journal of Pharmacy and Pharmacology 1986; 38: 506–509

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.