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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 2
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Research Article

Metabolism and disposition of phenazopyridine in rat

B. H. Thomas Drug Toxicology Division, Bureau of Drug Research, Sir F. G. Banting Research Centre, Tunney's Pasture, Ottawa, Ontario, K1A 0L2, Canada
,
L. W. Whitehouse Drug Toxicology Division, Bureau of Drug Research, Sir F. G. Banting Research Centre, Tunney's Pasture, Ottawa, Ontario, K1A 0L2, Canada
,
G. Solomonraj Drug Toxicology Division, Bureau of Drug Research, Sir F. G. Banting Research Centre, Tunney's Pasture, Ottawa, Ontario, K1A 0L2, Canada
&
C. J. Paul Drug Toxicology Division, Bureau of Drug Research, Sir F. G. Banting Research Centre, Tunney's Pasture, Ottawa, Ontario, K1A 0L2, Canada
Pages 99-105 | Received 07 Jan 1992, Accepted 21 Sep 1993, Published online: 22 Sep 2008

References

  • Bailey K., Thomas B. H., VÉZina M., Whitehouse L. W., Zeitz W., Solomonraj G. 2,6-Diamino-5-hydroxy-3-(phenylazo)pyridine, a novel metabolite of phenazopyridine in the rat. Drug Metabolism and Disposition 1983; 11: 277–278
  • Foster B. C., Thomas B. H., Zamecnik J., Dawson B. A., Wilson D. L., Duhaime R., Solomonraj Mc G., Gilveray I. J., Lodge B. A. Aromatic hydroxylation and sulfation of phenazopyridine by. Cunninghamella echinulata. Canadian Journal of Microbiology 1991; 37: 504–509
  • Goldfinger S. E., Marx S. Hypersensitivity hepatitis due to phenazopyridine hydrochloride. New England Journal of Medicine 1972; 286: 1090–1091
  • Green E. D., Zimmerman R. C., Ghurabi W. H., Colohan D. P. Phenazopyridine hydrochloride toxicity: a cause of drug-induced methemoglobinemia. Journal of the American College of Energency Physicians 1979; 8: 426–431
  • Hirom P. C., Millburn P., Smith R. L., Williams R. T. Species variations in the threshold molecular-weight factor for the biliary excretion of organic anions. Biochemical Journal 1972; 129: 1071–1077
  • Johnson W. J., Chartrand A. The metabolism and excretion of phenazopyridine hydrochloride in animals and man. Toxicology and Applied Pharmacology 1976; 37: 371–376
  • Mudge G. H., Gemborys M. W., Duggin G. G. Covalent binding of metabolites of acetaminophen to kidney protein and depletion of renal glutathione. Journal of Pharmacology and Experimental Therapeutics 1978; 206: 218–226
  • Shreve R. N., Swaney M. W., Riechers E. H. Studies in azo dyes. I. Preparation and bacteriostatic properties of azo derivatives of 2,6-diaminopyridine. Journal of the American Chemical Society 1943; 65: 2241–2243
  • Thomas B. H., Whitehouse L. W., Solomonraj G., Paul C. J. Excretion of phenazopyridine and its metabolites in the urine of humans, rats, mice, and guinea pigs. Journal of Pharmaceutical Sciences 1990; 79: 321–325
  • Thomas B. H., Coldwell B. B., Solomonraj G., Zeitz W., Trenholm H. L. Effect of ethanol on the fate of pentobarbital in rat. Biochemical Pharmacology 1972; 21: 2605–2614
  • Tomlinson B., Cohen S. L., Smith M. R., Fisher C. Nephrotoxicity of phenazopyridine. Human Toxicology 1983; 2: 539–543

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