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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 3
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Research Article

Propachlor-S-cysteine: A major circulating metabolite in the calf, pig and rat after administration of propachlor

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Pages 297-305 | Received 16 Jul 1992, Accepted 24 Oct 1992, Published online: 22 Sep 2008

References

  • Anders M. W. Metabolism of drugs by the kidney. Kidney International 1980; 18: 636–647
  • Aschbacher P. W., Strubble C. B. Evidence of involvement of non-biliary excretion into the intestines in the formation of methylsulphonyl-containing metabolites of 2-chloro-N-isopropylacetanilide (propachlor) in swine and rats. Xenobiotica 1987; 17: 1047–1055
  • Bakke J. E., Davison K. L., Larsen G. L. Evidence for the absence of cysteine-S-conjugate N-acetyltransferase activity in the metabolism of propachlor, naphthalene, and dichlobanil in calves. Xenobiotica 1990; 20: 801–807
  • Bakke J. E., Feil V. J., Price C. E. Replacement of a chlorine with a methylsulfonyl group in the metabolism of propachlor (2-chloro-N-isopropylacetanilide). Biomedical Mass Spectrometry 1976; 3: 226–229
  • Bakke J. E., Larsen G. L. Metabolism of 2-chloro-N-isopropylacetanilide in chicken. Chemosphere 1985; 14: 1749–1754
  • Bakke J. E., Price C. E. Metabolism of 2-chloro-N-isopropylacetanilide (propachlor) in the sheep and milk goat. Journal of Environmental Science and Health 1979a; B14(3)291–304
  • Bakke J. E., Price C. E. Metabolism of 2-chloro-N-isopropylacetanilide (propachlor) in the rat. Journal of Environmental Science and Health 1979b; B14(4)427–441
  • Bakke J. E., Rafter J., Larsen G. L., Gustafsson J. A., Gustafsson B. E. Enterohepatic circulation of the mercapturic acid and cysteine conjugates of propachlor. Drug Metabolism and Disposition 1981; 9: 525–528
  • Bradford M. H. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976; 72: 248–254
  • Davison K. L. In situ perfusion and collection techniques for studying xenobiotic metabolism in animals. Intermediary Xenobiotic Metabolism in Animals: Methodology Mechanisms and Significance, D. H. Hutson, J. Caldwell, G. D. Paulson. Taylor & Francis, London 1989; 315–333
  • Davison K. L., Bakke J. E., Larsen G. L. A kidney perfusion method for metabolism studies with chickens using propachlor as a model. Xenobiotica 1988; 18: 323–329
  • Davison K. L., Bakke J. E., Larsen G. L. Metabolism of the glutathione conjugate of propachlor by in situ perfused kidneys and livers of rats. Xenobiotica 1990; 20: 375–383
  • Dayton P. G., Israili Z. H., Henderson J. D. Elimination of drugs by passive diffusion from blood to intestinal lumen: factors influencing nonbiliary excretion by the intestinal tract. Drug Metabolism Reviess 1983; 14: 1193–1206
  • Hawk P. B., Oser B. L., Summerson W. H. Practical Physiological Chemistry. McGraw Hill, New York 1954; 543–545
  • Inoue M., Okajima K., Morino Y. Metabolic coordination of liver and kidney in mercapturic acid biosynthesis, in vivo. Hepatology 1982; 2: 636–647
  • Lamoureux G. L., Davison K. L. Mercapturic acid formation in the metabolism of propachlor, CDAA, and fluorodifen in the rat. Xenobiotica 1975; 11: 473–480
  • Larsen G. L., Bakke J. E. Enterohepatic circulation in formation of propachlor (2-chloro-N-isopropylacetanilide) metabolites in the rat. Xenobiotica 1981; 11: 473–480
  • Larsen G. L., Bakke J. E. Metabolism of mercapturic acid-pathway metabolites of 2-chloro-N-isopropylacetanilide (propachlor) by gastrointestinal bacteria. Xenobiotica 1983; 13: 115–126
  • Lash L. H., Jones D. P. Uptake of the glutathione conjugate S-(1,2,-dichlorovinyl) glutathione by renal basal-lateral membrane vesicles and isolated kidney cells. Molecular Pharmacology 1985; 28: 278–282
  • Pekas J. C., Larsen G. L., Feil V. J. Propachlor detoxication in the small intestine: cysteine conjugation. Journal of Toxicology and Environmental Health 1979; 5: 653–662
  • Struble C. B. In situ intestinal absorption of 2-chloro-N-isopropylacetanilide (propachlor) and non-biliary excretion of metabolities into the intestinal tract of rats, pigs and chickens. Xenobiotica 1991; 21: 85–95

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