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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 5
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Research Article

Metabolism of thiodiglycol (2,2′-thiobis-ethanol): isolation and identification of urinary metabolites following intraperitoneal administration to rat

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Pages 473-481 | Received 26 Nov 1992, Accepted 23 Feb 1993, Published online: 22 Sep 2008

References

  • Black R. M., Brewster K., Clarke R. J., Hambrook J. L., Harrison J. M., Howells D. J. Biological fate of sulphur mustard, 1,1′-thiobis(2-chloroethane): isolation and identification of urinary metabolites following intraperitoneal administration to rat. Xenobiotica 1992a; 22: 405–418
  • Black R. M., Hambrook J. L., Howells D. J., Read R. W. Biological fate of sulphur mustard, 1,1′-thiobis(2-chloroethane). Urinary excretion profiles of hydrolysis products and β-lyase metabolites of sulphur mustard after cutaneous application in the rat. Journal of Analytical Toxicology 1992b; 16: 79–84
  • Black R. M., Brewster K., Harrison J. M., Stansfield N. The chemistry of 1,1′-thiobis(2-chloroethane) (sulphur mustard). Part 1. Some simple derivatives. Phosphorus, Sulphur and Silicon 1992c; 71: 31–47
  • Black R. M., Read R. W. Detection of trace levels of thiodiglycol in blood, plasma and urine using gas chromatography-electron-capture negative ion chemical ionisation mass spectrometry. Journal of Chromatography 1988; 449: 261–270
  • Black R. M., Read R. W. Methods for the analysis of thiodiglycol sulphoxide, a metabolite of sulphur mustard, in urine using gas chromatography-mass spectrometry. Journal of Chromatography 1991; 558: 393–404
  • Davies D. I., Hughes L., Vankar Y. D., Baldwin J. E. Synthesis of 1,4-oxathian-2-one, 5-methyl-1,4-oxathiepan-2-one. Journal of the Chemical Society Perkin Transactions 1977; I: 2476–2479
  • Davison C., Rozman R. S., Smith P. K. Metabolism of bis-β-chloroethyl sulphide (sulphur mustard gas). Biochemical Pharmacology 1961; 7: 65–74
  • Hambrook J. L., Harrison J. M., Howells D. J., Schock C. Biological fate of sulphur mustard, 1,1′-thiobis(2-chloroethane). Urinary and faecal excretion of 35S by rat after injection or cutaneous application of 35S-labelled sulphur mustard. Xenobiotica 1992; 22: 65–67
  • Harrison J. M. The synthesis of isotopically-labelled, 1,1′-thiobis(2-chloroethane) and some related compounds. Journal of Labelled Compounds and Radiopharmaceuticals 1991; XXIX: 1175–1180
  • Jackubowski E. M., Woodard C. L., Mershon M. M., Dolzine T. W. Quantification of thiodiglycol in urine by electron ionization gas chramatography-mass spectrometry. Journal of Chromatography 1990; 528: 184–190
  • Roberts J. J., Warwick G. P. Studies of the mode of action of alkylating agents-IV. The metabolism of bis-2-chloroethylsulphide (mustard gas) and related compounds. Biochemical Pharmacology 1963; 12: 1329–1334
  • United Nations Security Council. UNSC, New York 1984, Report of the specialists appointed by the Security-General to investigate allegations by the Islamic Public of Iran concerning use of chemical weapons. Report S-16433
  • United Nations Security Council. UNSC, New York 1986, Report of the mission dispatched by the Security-General to investigate allegations of the use of chemical weapons in the conflict between the Islamic Republic of Iran and Iraq. Report S-17911
  • United Nations Security Council. UNSC, New York 1988, Report of the mission dispatched by the Security-General to investigate allegations of the use of chemical weapons in the conflict between the Islamic State of Iran and Iraq. Report S-20134
  • Wils E. R. J., Hulst A. G., De Jong A. L., Verweij A., Boter H. K. Analysis of thiodiglycol in urine of victims of an alleged attack with mustard gas. Journal of Analytical Toxicology 1985; 9: 254–257
  • Wils E. R. J., Hulst A. G., Van Laar J. Analysis of thiodiglycol in urine of victims of an alleged attack with mustard gas. Journal of Analytical Toxicology 1988; 12: 15–19

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