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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 5
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Research Article

Biological fate of sulphur mustard (1,1′-thiobis(2-chloroethane)): uptake, distribution and retention of 35S in skin and in blood after cutaneous application of 35S-sulphur mustard in rat and comparison with human blood in vitro

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Pages 537-561 | Received 27 Nov 1992, Accepted 28 Jan 1993, Published online: 22 Sep 2008

References

  • Abell C. W. Thein vivo reaction of sulphur mustard with protein and ribonucleic acid isolated from the tissues of A/J mice. Proceedings of the American Association of Cancer Research 1964; 5: 1
  • Altman P. L., Dittmer D. S. Biology Data Book2nd edn. Federation of American Societies for Experimental Biology, Bethesda 1974; 1847
  • Berlin N. I., Meyer L. M., Lazarus M. Life span of the rat red blood cell as determined by glycine-2-14C. American Journal of Physiology 1951; 165: 565–567
  • Berlin N. I., Waldmann T. A., Weissman S. M. Life span of the rat red blood cell. Physiology Reviews 1959; 39: 577–616
  • Beutler E. Red Cell Metabolism. A Manual of Biochemical Methods3rd edn. Grune and Stratton Inc., London 1984
  • Black R. M., Brewster K., Clarke R. J., Hambrook J. L., Harrison J. M., Howells D. J. Biological fate of sulphur mustard, 1,1′-thiobis(2-chloroethane): isolation and identification of urinary metabolites following intraperitoneal administration to rat. Xenobiotica 1992b; 22: 405–418
  • Black R. M., Clarke R. J., Read R. W. A method for the analysis of 1,1′-sulphonylbis[2-(methylsulphinyl)ethane] and 1,1′-sulphonylbis[2-(methylsulphinyl)-2′-(methylthio)ethane], metabolites of sulphur mustard, in urine using gas chromatography-mass spectroscopy. Journal of Chromatography 1991; 558: 405–414
  • Black R. M., Hambrook J. L., Howells D. J., Read R. W. Biological fate of sulphur mustard, 1,1′-thiobis(2-chloroethane)—urinary excretion profiles of hydrolysis products and beta-lyase metabolites of sulphur mustard after cutaneous application in rats. Journal of Analytical Toxicology 1992a; 16: 79–84
  • Black R. M., Read R. W. Detection of trace levels of thiodiglycol in blood, plasma and urine using gas chromatography-electron-capture negative ion chemical ionisation mass spectroscopy. Journal of Chromatography 1988; 449: 261–270
  • Black R. M., Read R. W. Methods for the analysis of thiodiglycol sulphoxide, a metabolite of sulphur mustard, in urine using gas chromatography-mass spectrometry. Journal of Chromatography 1991; 558: 393–404
  • Boursnell J. C., Cohen J. A., Dixon M., Francis G. E., Greville G. D., Needham D. M., Wormall A. Studies on mustard gas (β,β'-dichlorodiethylsulphide) and some related compounds. V. The fate of injected mustard gas (containing radioactive sulphur) in the animal body. Biochemical Journal 1946; 40: 756–764
  • Davison C., Rozman R. S., Smith P. K. Metabolism of bis-β-chloroethylsulphide (sulphur mustard gas). Biochemical Pharmacology 1961; 7: 65–74
  • Garrick M. D., Garrick L. M., Chu M. L. Turnover of the major proteins of rat erythrocytes. Protein Turnover and Lysosome Function, H. L. Segal, D. J. Doyle. Academic Press, London 1978; 135–147
  • Hambrook J. L., Harrison J. M., Howells D. J., Schock C. Biological fate of sulphur mustard (1,1′-thiobis(2-chloroethane)): urinary and faecal excretion of 35S by rat after injection or cutaneous application of 35S-labelled sulphur mustard. Xenobiotica 1992; 22: 65–75
  • Harvard Bioscience. The Whole Rat Catalogue. Harvard Bioscience, South Natick, Ma 1983; 68
  • Hershko A., Heller H., Ganoth D., Ciehanover A. Mode of degradation of abnormal globin chains in rabbit reticulocytes. Protein Turnover and Lysosome Function, H. L. Segal, D. J. Doyle. Academic Press, London 1978; 149–169
  • International Agency for Research on Cancer. Some aziridines, N-, S- and O-mustards and selenium. IARC, Lyon 1975; Vol. 9: 181–192, IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man
  • Jones A. R. The metabolism of biological alkylating agents. Drug Metabolism Reviews 1973; 2: 71–100
  • Mowrer J., Tornqvist M., Jensen S., Ehrenberg L. Modified Edman degradation applied to haemoglobin for monitoring occupational exposure to alkylating agents. Toxicological and Environmental Chemistry 1986; 11: 215–231
  • Roberts J. J., Warwick G. P. Studies of the mode of action of alkylating agents. VI. The metabolism of bis-2-chloroethylsulphide (mustard gas) and related compounds. Biochemical Pharmacology 1963; 12: 1329–1334
  • Schalm O. W., Jain N. C. The erythrocyte: its morphology, metabolism and survival. chapter 20. Veterinary Haematology4th edn. Lea and Febiger, Philadelphia 1986
  • Smith L. H., Odell T. T., Caldwell B. Life span of rat erythrocytes as determined by 51Cr and differential agglutination methods. Proceedings of the Society of Experimental Biology and Medicine 1959; 100: 29–31
  • Somani S. M. Toxicokinetics and toxicodynamics of mustard. chapter 18. Chemical Warfare Agents, S. M. Somani. Academic Press, New York 1992; 13–50
  • Somani S. M., Babu S. R. Toxicodynamics of sulfur mustard. International Journal of Clinical Pharmacology, Therapy and Toxicology 1989; 27: 419–435
  • United Nations Security Council. UN Security Council, New York 1984, Report of the specialists appointed by the Secretary-General to investigate allegations by the Islamic Republic of Iran concerning the use of chemical weapons. Report S-16433
  • United States Security Council. UN Security Council, New York 1986, Report of the mission despatched by the Secretary-General to investigate allegations of the use of chemical weapon in the conflict between the Islamic Republic of Iran and Iraq. Report S-17911
  • United Nations Security Council. UN Security Council, New York 1988, Report of the mission despatched by the Secretary-General to investigate allegations of the use of chemical weapons in the conflict between the Islamic Republic of Iran and Iraq. Report S-20134
  • Varley H., Gowenlock A. H., Bell M. Practical Clinical Biochemistry5th edn. Heinemann Medical, London 1980; Vol. 1: 489–534
  • Willems J. L. Clinical management of mustard gas casualties. Annales Medicinae Militaries Belgicae 1989; 3, Suppl.

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