Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 6
54
Views
32
CrossRef citations to date
0
Altmetric
Research Article

Effect of phenobarbital and other model inducers on cytochrome P450 isoenzymes in primary culture of dog hepatocytes

&
Pages 681-692 | Received 10 Nov 1992, Accepted 20 Mar 1993, Published online: 22 Sep 2008

References

  • Bars R. G., Mitchell A. M., Wolf C. R., Elcombe C. R. Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry. Biochemical Journal 1989; 262: 151–158
  • Breckenridge A., Orme M. L'E., Davies L., Thorgeirsson S. S., Davis D. S. Dose-dependent enzyme induction. Clinical and Pharmacological Therapeutics 1973; 14: 514–520
  • Chenery R. J., Ayrton A., Oldham H. G., Norman S. J., Standring P. The interaction of omeprazole with rat liver cytochrome P450-mediated monoxygenase reactions. in vitro and in vivo. Biochemical Pharmacology 1988; 37: 1407–1414
  • Ciaccio P. J., Graves P. E., Bourque D. P., Glinsmann-Gibson B., Halpert J. R. cDNA and deduced amino acid sequences of dog liver cytochrome P-450 of the IIIA gene subfamily. Biochimica Biophysica Acta 1991; 1088: 319–322
  • Ciaccio P. J., Halpert J. R. Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450 IIIA (steroid-inducible) gene subfamily. Archives of Biochemistry and Biophysics 1989; 271: 284–299
  • Diaz D., Fabre I., Daujat M., Aubert B. S., Bories P., Michel H., Maurel P. Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P-450. Gastroenterology 1990; 99: 737–747
  • Duignan D. B., Sipes I. G., Ciaccio P. J., Halpert J. R. The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P-450 PBD-2. Archives of Biochemistry Biophysics 1988; 267: 294–304
  • Graves P. E., Elhag G. A., Ciaccio P. J., Bourque D. P., Halpert J. R. cDNA and amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2′,4,4′,5,5′-hexachlorobiphenyl. Archives of Biochemistry and Biophysics 1990; 281: 106–115
  • Holme J. A., SodÉRlund E., Dybing E. Drug metabolism activities of isolated rat hepatocytes in monolayer culture. Acta Pharmacologica et Toxicologica 1983; 52: 348–356
  • Imaoka S., Terano Y., Funae Y. Constitutive testosterone 6β-hydroxylase in rat liver. Journal of Biochemistry 1988; 104: 481–487
  • Ioannides C., Parke D. V. Mechanism of induction of hepatic microsomal drug metabolizing enzymes by a series of barbiturates. Journal of Pharmaceutics and Pharmacology 1975; 27: 739–746
  • Ioannides C., Parke D. V. The cytochrome P450I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug McTabolism Reviews 1990; 22: 1–85
  • Jauregui H. O., Ng S.-F., Gann K. L., Waxman D. J. Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes. Xenobiotica 1991; 21: 1091–1106
  • Kocarek T. A., Schuetz E. G., Guzelian P. S. Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes. Molecular Pharmacology 1990; 38: 440–444
  • Komori M., Shimada H., Miura T., Kamataki T. Interspecies homology of liver microsomal cytochrome P-450. A form of dog cytochrome P-450 (P-450-D1) crossreactive with antibodies to rat P-450-male. Biochemical Pharmacology 1989; 38: 235–240
  • Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–685
  • Lan S. J., Weinstein S. H., Keim G. R., Migdalof B. H. Induction of hepatic drug-metabolizing enzymes in rats, dogs and monkeys after repeated administration of an antiinflammatory hexahydroindazole. Xenobiotica 1983; 13: 329–335
  • Lange R., Balny C., Maurel P. Inductive and repressive effects of rifampicin on rabbit liver microsomal cytochrome P-450. Biochemical Pharmacology 1984; 33: 2771–2776
  • Lange R., Larroque C., Balny C., Maurel P. Isolation and partial characterization of a rifampicin induced rabbit liver microsomal cytochrome P-450. Biochemistry and Biophysics Research Communications 1985; 126: 833–839
  • Lavrijsen K., Houdt J. V., Dyck D. V., Hendrickx J., Bockx M., Hurkmans R., Meuldermans W., Jeune L. L., Lauwers W., Heykants J. Comparative metabolism of flunarizine in rats, dogs and man: anin vitro study with subcellular liver fractions and isolated hepatocytes. Xenobiotica 1992; 22: 815–836
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Maslansky C. J., Williams G. M. Primary cultures and the levels of cytochrome P-450-in hepatocytes from mouse, rat, hamster, and rabbit liver. In Vitro 1982; 18: 683–693
  • Matsubara T., Otsubo S., Yoshihara E. Liver microsomal cytochrome P-450-dependent O-dealkylation reaction in various animals. Japanese Journal of Pharmacology 1983a; 33: 1065–1075
  • Matsubara T., Otsubo S., Yoshihara E., Touchi A. Biotransformation of coamarin derivatives (2) oxidative metabolism of 7-alkoxycoumarin by microsomal enzymes and simple assay procedure for 7-alkoxycoumarinO-dealkylase. Japanese Journal of Pharmacology 1983b; 33: 41–56
  • Matsubara T., Touchi A., Ogawa A. Heterogeneous distribution of the cytochrome P-450 monooxygenase system in rat liver lobes. Japanese Journal of Pharmacology 1982; 32: 999–1011
  • McKillop D. Effects of phenobarbitone and β-naphthoflavone on hepatic microsomal drug metabolising enzymes of the male beagle dog. Biochemical Pharmacology 1985; 34: 3137–3142
  • Michalopoulos G., Sattler C. A., Sattler G. L., Pitot H. C. Cytochrome P-450 induction by phenobarbital and 3-methylcholanthrene in primary cultures of hepatocytes. Science 1976; 193: 907–909
  • Miyazaki M., Handa Y., Oda M., Yabe T., Miyano K., Sato J. Long-term survival of functional hepatocytes from adult rat in the presence of phenobarbital in primary culture. Experimental Cell Research 1985; 159: 176–190
  • Moldéus P., Högberg J., Orrenius S. Isolation and use of liver cells. Methods in Enzymology, S. Fleischer, L. Packer. Marcel Dekker, New York 1978; Vol. 52: 60–71
  • Morel F., Beaune P. H., Ratanasavanh D., Flinois J. P., Yang C. S., Guengerich F. P., Guillouzo A. Expression of cytochrome P-450 enzymes in cultured human hepatocytes. European Journal of Biochemistry 1990; 191: 437–444
  • Namiki M., Degawa M., Masuko T., Hashimoto Y. Changes in the quantity and activity of cytochrome P-450 isosymes in primary cultured rat hepatocytes. Japanese Journal of Cancer Research 1989; 80: 126–131
  • Niemann C., Gauthier J. C., Richert L., Ivanov M. A., Melcion C., Cordier A. Rat adult hepatocytes in primary pure and mixed monolayer culture. Comparison of the maintenance of mixed function oxidase and conjugation pathways of drug metabolism. Biochemical Pharmacology 1991; 42: 373–379
  • Okuno H., Nakanishi S., Kitao Y., Takasu M., Murase T., Shiozaki Y., Sameshima Y. Comparison of the effects of various inducers on 7-alkoxycoumarinO-dealkylase activities in liver microsomes. Japanese Journal of Pharmacology 1989; 50: 1–9
  • Paine A. J. The maintenance of cytochrome P-450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system. Chemical-Biological Interactions 1990; 74: 1–31
  • Parke B. K., Breckenridge A. M. Clinical implications of enzyme induction and enzyme inhibition. Clinical Pharmacokinetics 1981; 6: 1–24
  • Parke D. V. The endoplasmic reticulum: its role in physiological functions and pathological situations. Concepts in Drug Metabolism, Part B, P. Jenner, B. Testa. Marcel Dekker, New York 1981; 1–52
  • Pasco D. S., Boyum K. W., Merchant S. N., Chalberg S. C., Fagan J. B. Transcriptional and post-transcriptional regulation of the genes encoding cytochromes P-450c and P450din vivo and in primary hepatocyte cultures. Journal of Biological Chemistry 1988; 263: 8671–8676
  • Shiraga T., Iwasaki K. Purification and characterization of cytochrome P-450 from liver microsomes of beagle dogs. Journal of Pharmacobio-Dynamics 1991; 14: s50
  • Sogawa K., Gotoh O., Kawajiri K., Fujii-Kuriyama Y. Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 gene in the rat. Proceedings of the National Academy of Sciences, USA 1984; 81: 5066–5070
  • SouĆEk P., Gut I. Cytochromes P-450 in rats: structures, functions, properties and relevant human forms. Xenobiotica 1992; 22: 83–103
  • Swinney D. C. Progesterone metabolism in hepatic microsomes. Effect of the cytochrome P-450 inhibitor, ketoconazole, and the NADPH 5α-reductase inhibitor, 4-MA, upon the metabolic profile in human, monkey, dog and rat. Drug Metabolism and Disposition 1990–1990; 18: 859–865
  • Testa B., Jenner P. Inhibitors of cytochrome P-450s and their mechanism of action. Drug Metabolism Reviews 1981; 12: 1–117
  • Tong J. Z., De Lagausie P., Furlan V., Cresteil T., Bernard O., Alvarez F. Long-term culture of adult rat hepatocyte spheroids. Exprimental Cell Research 1992; 200: 326–332
  • Uchida T., Komori M., Kitada M., Kamataki T. Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs. Molecular Pharmacology 1990; 38: 644–651
  • Vukicevic S., Kleinman H. K., Luyten F. P., Roberts A. B., Roche N. S., Reddi A. H. Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Experimental Cell Research 1992; 202: 1–8
  • Warren M., Fry J. R. Influence of medium composition of 7-alkoxycoumarinO-dealkylase activities of rat hepatocytes in primary maintenance culture. Xenobiotica 1988; 18: 973–981
  • Waxmann D. J., Ko A., Walsh C. Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver. Journal of Biological Chemistry 1983; 258: 11937–11947
  • Waxman D. J., Morrissey J. J., Naik S., Jauregui H. O. Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response. Biochemical Journal 1990; 271: 113–119

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.