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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 11
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Research Article

Metabolism and enantioselective pharmacokinetics of Casodex in man

D. McKillop Safety of Medicines Department and Medical Research Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
G. W. Boyle Safety of Medicines Department and Medical Research Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
I. D. Cockshott Safety of Medicines Department and Medical Research Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
D. C. Jones Safety of Medicines Department and Medical Research Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
P. J. Phillips Safety of Medicines Department and Medical Research Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
&
R. A. Yates Safety of Medicines Department and Medical Research Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
Pages 1241-1253 | Received 04 Nov 1992, Accepted 03 May 1993, Published online: 22 Sep 2008

References

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  • Cockshott I. D., Cooper K. J., Sweetmore D. S., Blacklock N. J., Denis L. The pharmacokinetics of Casodex in prostate cancer patients after single and during multiple dosing. European Urology 1990; 18: 10–17, Suppl. 3
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  • Furr B. J. A. Casodex (ICI 176,334)—a new, pure, peripherally-selective antiandrogen: preclinical studies. Hormone Research 1989; 32: 69–76, Suppl. 1
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  • Newling D. W. W. The response of advanced prostatic cancer to a new non-steroidal antiandrogen: results of a multicenter open phase II study of Casodex. European Urology 1990; 18: 18–21, Suppl. 3
  • Schulz M., Schmoldt A., Donn F., Becker H. The pharmacokinetics of Flutamide and its major metabolites after a single oral dose and during chronic treatment. European Journal of Clinical Pharmacology 1988; 34: 633–636
  • Tucker H., Crook J. W., Chesterson G. J. Nonsteroidal anti-androgens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides. Journal of Medicinal Chemistry 1988; 31: 954–959

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