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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 11
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Research Article

The disposition and metabolic fate of 14C-meropenem in man

M. P. Harrison ZENECA Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
S. J. Haworth ZENECA Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
S. R. Moss ZENECA Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
D. M. Wilkinson ZENECA Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
&
A. Featherstone ZENECA Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
Pages 1311-1323 | Received 24 Mar 1993, Accepted 06 Jul 1993, Published online: 22 Sep 2008

References

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  • Bergan T., Nord C. E., Thorsteinsson S. B. Effect of meropenem on the intestinal microflora. European Journal of Clinical Microbiological and Infectious Diseases 1991; 10: 524–527
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  • King A., Boothman C., Philips I. Comparative in vitro activity of meropenem on clinical isolates from the United Kingdom. Journal of Antimicrobial Chemotherapy 1989; 24: 31–45, Suppl. A
  • Kropp H., Sundelof J. G., Hajdu R., Kahan F. M. Metabolism of thienamycin and related carbapenem antibiotics by renal dipeptidase: dehydropeptidase 1. Antimicrobial Agents and Chemotherapy 1982; 22: 62–70
  • Nihlsson-Ehle I., Hutchison M., Haworth S. J., Norrby S. R. Pharmacokinetics of meropenem compared to imipenem-cilastatin in young healthy, males. European Journal of Clinical Microbiology and Infectious Diseases 1991; 10: 85–88
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  • Norrby S. R., Rodgers J. D., Ferber F., Jones K. H., Zacchei A. G., Weidner L. L., Demetriades J. L., Gravallese D. A., Hsieh Y.-K. Disposition of radiolabelled imipenem and cilastatin in normal human volunteers. Antimicrobial Agents and Chemotherapy 1984; 26: 707–714
  • Tanio T., Nouda H., Tada E., Kohzuki T., Kato M., et al. SM-7338, a new carbapenem antibiotic: renal dehydropeptidase 1 stability and pharmacokinetics in animals. Program and Abstracts of the 27th Interscience Conference on Antimicrobial Agents and Chemotherapy New York, 1987. American Society for Microbiology, Washington, DC 1987; 758: 229, Abstract
  • Topham J. C., Murgatroyd L. B., Jones D. V., Goonetilleke U. R. P., Wright J. Safety evaluation of meropenem in animals: studies on the kidney. Journal of Antimicrobial Chemotherapy 1989; 24: 287–306, Suppl. A

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