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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 7
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Original Article

Metabolic fate and disposition of 1,1,1,2-tetrafluoroethane (HFC134a) in rat following a single exposure by inhalation

M. K. Ellis Investigative Toxicology Section, ZENECA Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, SK10 4TJ, UK
,
L. A. Gowans Investigative Toxicology Section, ZENECA Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, SK10 4TJ, UK
,
T. Green Investigative Toxicology Section, ZENECA Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, SK10 4TJ, UK
&
R. J. N. Tanner Glaxo Group Research Ltd, Park Road, Ware, SG12 0DP, UK
Pages 719-729 | Received 17 Nov 1992, Accepted 08 May 1993, Published online: 23 Apr 2010

References

  • Fraser J. M., Kaminsky L. S. Metabolism of 2,2,2-trifluoroethanol and its relationship to toxicity. Toxicology and Applied Pharmacology 1987; 89: 202–210
  • Green T., Prout M. S. Species differences in response to trichloroethylene. II Biotransformation in rats and mice. Toxicology and Applied Pharmacology 1985; 79: 401–411
  • Guyton A. C. Measurement of respiratory volumes of laboratory animals. American Journal of Physiology 1947; 150: 70–77
  • Karashima D., Shigematsu A., Furukawa T. Esterification of trifluoroacetic acid with phenyldiazomethane for quantitative gas chromatographic analysis. Journal of Chromatography 1977; 130: 77–86
  • Kearney P. C., Kaufman D. D., von Endt D. W., Guardia F. S. TCA metabolism by soil micro-organisms. Journal of Agriculture and Food Chemicals 1969; 17: 581–584
  • Klemm H. P., Hintze U., Gercken G. Quantitative preparation and gas chromatography of short and medium chain fatty acid benzyl esters. Journal of Chromatography 1973; 75: 70–77
  • Larson J. L., Bull R. J. Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicology and Applied Pharmacology 1992; 115: 268–277
  • Molina M. J., Rowland F. S. Stratospheric sink for chlorofluoromethanes: chlorine atomcatalysed destruction of ozone. Nature 1974; 249: 810–812
  • Olson M. J., Kim S. G., Reidy C. A., Johnson J. T., Novak R. F. Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalysed primarily by cytochrome P450IIE1. Drug Metabolism and Disposition 1991; 19: 298–303
  • Olson M. J., Reidy C. A., Johnson J. T. Defluorination of 1,1,1,2-tetrafluoroethane (R-134a) by rat hepatocytes. Biochemical and Biophysical Research Communications 1990a; 166: 1390–1396
  • Olson M. J., Reidy C. A., Johnson J. T., Pederson T. C. Oxidative defluorination of 1,1,1,2-tetrafluoroethane by rat liver microsomes. Drug Metabolism and Disposition 1990b; 18: 992–998
  • Olson M. J., Surbrook S. E., Jr. Defluorination of the CFC-substitute 1,1,1,2-tetrafluoroethane: comparison in human, rat and rabbit hepatic microsomes. Toxicology Letters 1991; 59: 89–99
  • Overberger C. G., Anselme J. P. A convenient synthesis of phenyldiazomethane. Journal of Organic Chemistry 1963; 28: 592–593
  • Surbrook S. E., Jr., Olson M. J. Dominant role of cytochrome P-450 2EI in human hepatic microsomal oxidation of the CFC-substitute 1,1,1,2-tetrafluoroethane. Drug Metabolism and Disposition 1992; 20: 518–524

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