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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 3
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Abstracts Article

Protection by ascorbic acid against oxidative injury of isolated hepatocytes

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Pages 281-289 | Received 19 Aug 1993, Published online: 27 Aug 2009

References

  • Antonenkov V. D., Sies H. Ascorbate-dependent capacity of dialysed rat liver cytosol to prevent nonenzymatic lipid peroxidation. Biological Chemistry Hoppe-Seyler 1992; 373: 1111–1116
  • Bacharach A. L., Allchorne J. The Biological Standards of the Vitamins, K. H. Coward. Baillière, London 1947; 147–149
  • Bissel D. M., Guzelian P. S. Ascorbic acid deficiency and cytochrome P-450 in adult rat hepatocytes in primary monolayer culture. Archives of Biochemistry and Biophysics 1979; 192: 569–576
  • Bodannes R. S., Chan P. C. Ascorbic acid as a scavenger of singlet oxygen. FEBS Letters 1979; 105: 195–196
  • Casini A. F., Pompella A., Comporti M. Liver glutathione depletion induced by bromobenzene, iodobenzene, and diethylmaleate poisoning and its relation to lipid peroxidation and necrosis. American Journal of Pathology 1985; 118: 225–237
  • Connor H. D., Lacagnin L. V., Knecht K. T., Thurman R. G., Mason R. P. Reaction of glutathione with a free radical metabolite of carbon tetrachloride. Molecular Pharmacology 1990; 37: 443–451
  • Di Simplicio P., Mannervik K. Enzymes involved in glutathione metabolism in rat liver and blood after carbon tetrachloride intoxication. Toxicology Letters 1983; 18: 285–290
  • Dogterom P., Nagelkerke J. F., Van Steveninck J., Mulder G. J. Inhibition of lipid peroxidation by disulfiram and diethyldithiocarbamate does not prevenr hepatotoxin-induced cell death in isolated rat hepatocites. A study with allyl alcohol, tert-butylhydroperoxide, diethyl maleate, bromoisovalerylurea and carbon tetrachloride. Chemico-Biological Interactions 1988; 66: 251–265
  • Fukuzawa K., Seko T., Minimi J., Terao J. Dynamics of iron-ascorbate-induced lipid peroxidation in charged and uncharged phospholipid vesicles. Lipids 1993; 28: 497–503
  • Fulceri R., Pompella A., Benedetti A., Comporti M. On the role of lipid peroxidation and protein-bound aldehydes in the haloalkane-induced inactivation of microsomal glucose 6-phosphatase. Research Communications in Chemical Pathology and Pharmacology 1990; 68: 73–88
  • Garcia-Castineiras S., Diaz Bonnet V., Figueroa R., Miranda M. Ascorbic acid determination by hydrophobic liquid chromatography of the osazone derivative. Application to the analysis of aqueous humor. Journal of Liquid Chromatography 1981; 4: 1619–1640
  • Halliwell B., Foyer C. H. Ascorbic acid, metal ions and the superoxide radical. Biochemical Journal 1976; 155: 697–700
  • Jaeschke H., Kleinwaechter C., Wendel A. The role of acrolein in allyl alcohol induced lipid peroxidation and liver cell damage in mice. Biochemical Pharmacology 1987; 36: 51–58
  • Koster J. F., Slee R. G., Montfoort A., Lang J., Esterbauer H. Comparison of the inactivation of microsomal glucose 6-phosphatase by in situ lipid peroxidation-derived 4-hydroxynonenal and exogenous 4-hydroxynonenal. Free Radical Research Communications 1986; 1: 273–287
  • Maellaro E., Casini A. F., Del Bello B., Comporti M. Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents. Biochemical Pharmacology 1990; 39: 1513–1521
  • Maiorino M., Coassin M., Roveri A., Ursini F. Microsomal lipid peroxidation: effect of vitamin E and its functional interaction with phospholipid hydroperoxide glutathione peroxidase. Lipids 1989; 24: 721–726
  • Miccadei S., Kyle M. E., Gilfor D., Farber J. L. Toxic consequence of the abrupt depletion of glutathione in cultured rat hepatocytes. Archives of Biochemistry and Biophysics 1988b; 265: 311–320
  • Miccadei S., Nakae D., Kyle M. E., Gilfor D., Farber J. L. Oxidative cell injury in the killing of cultured hepatocytes by allyl alcohol. Archives of Biochemistry and Biophysics 1988a; 265: 302–310
  • Nakagawa Y., Cotgreave I. A., Moldéus P. Relationships between ascorbic acid and α-tocopherol during diquat-induced redox cycling in isolated rat hepatocytes. Biochemical Pharmacology 1991; 42: 883–888
  • Niki E. Action of ascorbic acid as a scavenger of active and stable oxygen radicals. American Journal of Clinical Nutrition 1991; 54: 1119S–1124S
  • Packer I. E., Slater T. F., Willson R. L. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 1979; 278: 737–738
  • Poli G., Gravela E., Albano E., Dianzani M. U. Studies on fatty liver with isolated hepatocytes. II. The action of carbon tetrachloride on lipid peroxidation, protein, and triglyceride synthesis and secretion. Experimental and Molecular Pathology 1979; 30: 116–127
  • Pompella A., Maellaro E., Casini A. F., Ferrali M., Ciccoli L., Comporti M. Measurement of lipid peroxidation in vivo: a comparison of different procedures. Lipids 1987; 22: 206–211
  • Pompella A., Romani A., Bendetti A., Comporti M. Loss of membrane protein thiols and lipid peroxidation in allyl alcohol hepatotoxicity. Biochemical Pharmacology 1991; 41: 1255–1259
  • Rao K. S., Glende E. A., Jr., Recknagel R. O. Effect of drug pretreatment on carbon tetrachloride-induced lipid peroxidation in rat liver microsomal lipids. Experimental and Molecular Pathology 1970; 12: 324–331
  • Recknagel R. O., Lowrey K., Waller R. L., Glende E. A., Jr. Destruction of microsomal calcium pump activity: a possible secondary, mechanism in BrCCl3 and CCl4 liver cell injury. Advances in Experimental Biology and Medicine 1982; 136A: 619–631
  • Scarpa M., Rigo A., Maiorino M., Ursini F., Gregolin C. Formation of α-tocopherol radical and recycling of α-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes. An electron paramagnetic resonance study. Biochimica et Biophysica Acta 1984; 801: 215–219
  • Sedlak J., Lindsay R. H. Estimation of total, protein-bound, and non-protein sulphydryl groups in tissue with Ellman's reagent. Analytical Biochemistry 1966; 25: 192–205
  • Thor H., Smith M. T., Hartzell P., Bellomo G., Jewell S. A., Orrenius S. The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. Journal of Biological Chemistry 1982; 257: 12419–12425
  • Wayner D. D. M., Burton G. W., Ingold K. U. The antioxidant efficiency of vitamin C is concentration-dependent. Biochimica et Biophysica Acta 1986; 884: 119–123
  • Wefers H., Sies H. The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E. European Journal of Biochemistry 1988; 174: 353–357
  • Yamamoto K., Takahashi M., Niki E. Role of iron and ascorbic acid in the oxidation of methyl linoleate micelles. Chemical Letters 1987; 116: 1149–1152

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