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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 5
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Research Article

Hydrolysis, absorption and metabolism of di(2-ethylhexyl) terephthalate in the rat

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Pages 441-450 | Received 23 Sep 1993, Published online: 22 Sep 2008

References

  • Albro P. W. Tne metabolism of 2-ethylhexanol in rats. Xenobiotica 1975; 5: 625–636
  • Albro P. W., Corbett J. T., Schroeder J. L., Jordan S., Mathews H. B. Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP. Environmental Health Perspectives 1982a; 45: 19–25
  • Albro P. W., Hass J. R., Peck C. C., Odam D. G., Corbett J. T., Bailey J. F., Blatt H. E., Barrett B. B. Identification of metabolites of di(2-ethylhexyl) phthalate from the African green monkey. Drug Metabolism and Disposition 1981; 9: 223–225
  • Albro P. W., Jordan S., Schroeder J. L., Corbett J. T. Chromatographic separation and quantitative determination of the metabolites of di(2-ethylhexyl) phthalate from urine of laboratory animals. Journal of Chromatography 1982b; 244: 65–79
  • Albro P. W., Moore B. Identification of the metabolites of simple phthalate diesters in rat urine. Journal of Chromatography 1974; 78: 209–218
  • Albro P. W., Thomas R. O. Enzymatic hydrolysis of di(2-ethylhexyl)phthalate by lipases. Biochimica et Biophysica Acta 1973; 360: 380–390
  • Albro P. W., Thomas R. O., Fishbein L. Metabolism of diethylhexyl phthalate by rats: isolation and characterization of the urinary metabolites. Journal of Chromatography 1973; 76: 321–330
  • Astill B. D. Metabolism of DEHP: effects of prefeeding and dose variation, and comparative studies in rodents and the cynomolgous monkey. Drug and Metabolism Review 1989; 21: 35–53
  • Barber E. D. Genetic toxicology testing of di(2-ethylhexyl) terephthalate. Environmental and Molecular Mutagenesis 1994, in press
  • El-Hawari M., Murrill E., Stoltz M., Pallas F. Chemical Manufacturers Association study: metabolism and distribution of di(2-ethylhexyl)adipate. Midwest Research Institute, Kansas City, MO 1984, Final Report Contract No. PE-19, O-PK-MRI. MRI Project No. 7550-B
  • Harvan D. J., Hass J. R., Albro P. W., Friesen M. D. Mass spectrometry of di(2-ethylhexyl) phthalate metabolites. Biochemical and Medical Mass Spectrometry 1980; 7: 242–246
  • Keith Y., Cornu M. C., Canning P. M., Foster J., Lhuguenot J. C., Elcombe C. R. Peroxisome proliferation due to di(2-ethylhexyl) adipate, 2-ethylhexanol, and 2-ethylhexanoic acid. Archives of Toxicology 1992; 66: 321–326
  • Lake B. G., Phillips J. C., Linnel J. C., Gangolli S. D. The in vitro hydrolysis of some phthalate diesters by hepatic and intestinal preparations from various species. Toxicology and Applied Pharmacoloty 1977; 39: 239–248
  • Loftus N. J., Laird W. J. D., Steel G. T., Wilks M. F., Woollen B. H. Metabolism and pharmacokinetics of deuterium-labelled di(2-ethylhexyl) adipate (DEHA) in humans. Food and Chemical Toxicology 1993; 31: 609–614
  • Mitchell A., Lhuguenot L.-C., Bridges J. W., Elcombe C. Identification of the proximate proliferators derived from di(2-ethylhexyl) phthalate. Toxicology and Applied Pharmacology 1985; 80: 23–32
  • Rhodes C., Omen T., Pratt I., Balter P., Bratt H., Jackson S., Elcombe C. Comparative pharmacokinetics and subacute toxicity of DEHP in rats and marmosets. Environmental Health Perspectives 1986; 65: 299–308
  • Topping D. C., Ford G. P., Evans J. G., Lake B. G., O'Donoghue J. L., Lockhart H. B. Peroxisome induction studies on di(2-ethylhexyl) terephthalate. Toxicology and Industrial Health 1987; 3: 63–77
  • West E. S., Todd W. R. Textbook of Biochemistry3rd edn. Macmillan, New York 1964; 370

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