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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 6
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Research Article

Pharmacokinetics of the enantiomers of tertatolol in the rat after oral and intravenous administration

T. Lave Département de Chimie Thérapeutique, Faculté de Pharmacie, 74 Route du Rhin, 67400, Illkirch-Graffenstaden, France
,
C. Efthymiopoulos Département de Chimie Thérapeutique, Faculté de Pharmacie, 74 Route du Rhin, 67400, Illkirch-Graffenstaden, France
,
B. Van Overloop Département de Physiologie, Faculté de Pharmacie, 74 Route du Rhin, 67400, Illkirch-Graffenstaden, France
,
A. Gairard Département de Physiologie, Faculté de Pharmacie, 74 Route du Rhin, 67400, Illkirch-Graffenstaden, France
,
O. Crambes Institut de Recherche International Servier, Coubevoie, France
,
J. C. Koffel Département de Chimie Thérapeutique, Faculté de Pharmacie, 74 Route du Rhin, 67400, Illkirch-Graffenstaden, France
&
L. Jung Département de Chimie Thérapeutique, Faculté de Pharmacie, 74 Route du Rhin, 67400, Illkirch-Graffenstaden, France
 show all
Pages 561-568 | Received 14 Sep 1993, Published online: 22 Sep 2008

References

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  • Bastian G., Urien S., Bree F., Jolliet P., Rocher I., Crambes O., Tillement J. P. Stereoselective binding of tertatolol and of 4-hydroxytertatolol to human plasma proteins. European Journal of Drug Metabolism and Pharmacokinetics 1992; 17: 2–4
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  • Takahashi T., Ogata H., Kanno S., Takeuchi H. Plasma protein binding of propranolol enantiomers as a major determinant of their stereoselective tissue distribution in rats. Journal of Pharmacology and Experimental Therapeutics 1990; 252: 272–278
  • Urien S., Morin D., Renouard A., Rocher I., Tillement J. P. Variation in serum binding of tertatolol mediated by disease-induced modification of alpha-acid glycoprotein concentration. European Journal of Clinical Pharmacology 1988; 34: 381–385
  • Walle T., Webb J. G., Bagwell E. E., Walle U. K., Daniell H. B., Gaffney T. E. Stereoselective delivery and actions of beta receptor antagonists. Biochemical Pharmacology 1988; 37: 115–124
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