Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 9
26
Views
17
CrossRef citations to date
0
Altmetric
Original Article

Metabolism of 1,1-dichloro-2,2,2-trifluoroethane in rats

&
Pages 881-892 | Received 01 Mar 1994, Published online: 27 Aug 2009

References

  • Boocaard P. J., Commandeur J. N. M., Mulder G. J., Vermeulen N. P. E., Nagelkerke J. F. Toxicity of the cysteine-S-conjugates and mercapturic acids of four structurally related difluoroethylenes in isolated proximal tubular cells from rat kidney. Biochemical Pharmacology 1989; 38: 3731–3741
  • Bruschi S. A., West K., Crabb J. W., Stevens J. L. Mitochondrial P1 (cpn60) is a major target protein for modification by reactive metabolites of S-(1,1,2,2-tetrafluoroethyl)-L-cysteine (TFEC). Toxicologist 1993; 13: 231
  • Chen Q., Yu K., Stevens J. L. Regulation of the cellular stress response by reactive electrophiles. Journal of Biological Chemistry 1992; 267: 24322–24327
  • Cohen E. N., Trudell J. R., Edmunds H. N., Watson E. Urinary metabolites of halothane in man. Anesthesiology 1975; 43: 392–401
  • Commandeur J. N. M., Brakenhoff J. P. G., Kanter F. J. J., Vermeulen N. P. E. Nephrotoxicity of mercapturic acids of three structurally related 2,2-difluoroethylenes in the rat-indications for different bioactivation mechanisms. Biochemical Pharmacology 1988; 37: 4495–4504
  • Commandeur J. N. M., Oostendorp R. A. J., Schoofs P. R., Xu B., Vermeulen N. P. E. Nephrotoxicity and hepatotoxicity of 1,1-dichloro-2,2-difluoroethylene in the rat. Biochemical Pharmacology 1987; 36: 4229–4237
  • Dallmeier E., Henschler D. Halothan-Belastung am Arbeitsplatz im Operatioinssaal. Experimentelle Begründung für biologisches Monitoring und Aufstellung eines Grenzwertes. Deutsche medizinische Wochenschrift 1981; 106: 324–328
  • Dekant W., Lash L. H., Anders M. W. Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine. Proceedings of the National Academy of Sciences, USA 1987a; 84: 7443–7447
  • Dekant W., Martens G., Vamvakas S., Metzler M., Henschler D. Bioactivation of tetrachloroethylene-role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alleviation. Drug Metabolism and Disposition 1987b; 15: 702–709
  • Dekant W., Vamvakas S., Anders M. W. Biosynthesis, bioactivation, and mutagenicity of S-conjugates. Toxicology Letters 1990; 53: 53–58
  • Dekant W., Vamvakas S., Anders M. W. The kidney as a target organ for xenobiotics bioactivated by glutathione conjugation. Tissue Specific Toxicity: Biochemical Mechanisms, W. Dekant, H.-G. Neumann. Academic, London 1992; 163–194
  • Fisher D. A., Hales C. H., Filkin D. L., Ko M. K. W., Sze N. D., Connell P. S., Wuebbles D. J., Isaksen I. S. A., Stordal F. Model calculations of the relative effects of CFCs and their replacements on stratospheric ozone. Nature 1990; 344: 508–512
  • Gargas M. L., Clewell H. J., Andersen M. E. Metabolism of inhaled dihalomethanes in vivo: differentiation of kinetic constants for two independent pathways. Toxicology and Applied Pharmacology 1986; 82: 211–223
  • Harris J. W., Anders M. W. In vivo metabolism of the hydrochlorofluorocarbon 1,1-dichloro-1-fluoroethane (HCFC-141b). Biochemical Pharmacology 1991; 41: R13–16
  • Harrip J. W., Pohl L. R., Martin J. L., Anders M. W. Tissue acylation by the chlorofluorocarbon substitute 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123). Proceedings of the National Academy of Sciences, USA 1991; 88: 1407–1410
  • Kassahun K., Baillie T. A. Cytochrome P-450-mediated dehydrogenation of 2-n-propyl-2(E)-pentenoic acid, a pharmacologically-active metabolite of valproic acid, in rat liver microsomal preparations. Drug Metabolism and Disposition 1993; 21: 242–248
  • Malley L. A., Carakostas M. C., Hansen J. F., Trochimowicz H. J., Rusch G. M. Chronic toxicity of hydrochlorofluorocarbon HCFC-123. Toxicologist 1991; 11: 103
  • Malley L. A., Trochimowicz H. J., Rusch G. M., Carakostas M. C., Hansen J. F. Subchronic toxicity of HCFC-123 in rats. Toxicologist 1990; 10: 205
  • McFarland M., Kaye J. Chlorofluorocarbons and ozone. Photochemistry and Photobiology 1992; 55: 911–929
  • Müller R., Stier A. Modification of liver microsomal lipids by halothane metabolites: a multi nuclear NMR spectroscopic study. Naunyn-Schmiedeberg's Archives of Pharmacology 1982; 321: 234–237
  • Olson M. J., Johnson J. T., O'Gara J. F., Surbrook S. E. J. Metabolism in vivo and in vitro of the refrigerant substitute 1,1,1,2-tetrafluoro-2-chloroethane. Drug Metabolism and Disposition 1991a; 19: 1004–1011
  • Olson M. J., Kim S. G., Reidy C. A., Johnson J. T., Novak R. F. Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1. Drug Metabolism and Disposition 1991b; 19: 298–303
  • Olson M. J., Surbrook S. E. J. Defluorination of the CFC-substitute 1,1,1,2-tetrafluoroethane: comparison in human, rat and rabbit hepatic microsomes. Toxicology Letters 1991; 59: 89–99
  • Reichert D., Werner H. W., Metzler M., Henschler D. Molecular mechanisms of 1,1-dichloroethylene toxicity: excreted metabolites reveal different pathways of reactive intermediates. Archives of Toxicology 1979; 42: 159–169
  • Rowland F. S. Ozone depletion theory. Science 1993; 261: 1101–1103
  • Surbrook S. E. J., Olson M. J. Dominant role of cytochrome P-450 2E1 in human hepatic microsomal oxidation of the CFC-substitute 1,1,1,2-tetrafluoroethane. Drug Metabolism and Disposition 1992; 20: 518–524
  • Urban G., Speerschneider P., Dekant W. Metabolism of the chlorofluorocarbon-substitute 1,1-dichloro-2,2,2-trifluoroethane by rat and human liver microsomes: the role of cytochrome P-450 IIE1. Chemical Research in Toxicology 1994; 7: 170–177

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.