Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 4
15
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Stereoselective disposition and metabolism of pinacidil in rat

&
Pages 329-338 | Received 15 Jul 1993, Accepted 11 Nov 1993, Published online: 22 Sep 2008

References

  • Arrigoni-Martelli E., Nielsen C. K., Olsen U. B., Petersen H. J. N″-cyano-N-4-pyridyl-N′-1,2,2-trimethylpropylguanidine, monohydrate (P1134): a new, potent vasodilator. Experientia 1980; 36: 445–447
  • Debowski J., Jurczak J., Sybilska D. Resolution of some chiral mandelic acid derivatives into enantiomers by reversed-phase high-performance liquid chromatography via α- and β-cyclodextrin inclusion complexes. Journal of Chromatography 1983; 282: 83–88
  • Debowski J., Sybilska D., Jurczak J. β-Cyclodextrin as a chiral component of the mobile phase for the separation of mandelic acid into enantiomers in reversed-phase for the separation of mandelic acid into enantiomers in reversed-phase systems of high-performance liquid chromatography. Journal of Chromatography 1982; 237: 303–306
  • DeLong A. F., Oldham S. W., DeSante K. A., Nell G., Henry D. P. Disposition of [14C]pinacidil in humans. Journal of Pharmaceutical Sciences 1988; 77: 153–156
  • Eilertsen E., Hart J. W., Magnussen M. P., Sørensen H., Arrigoni-Martelli E. Pharmacokinetics and distribution of the new antihypertensive agent pinacidil in rat, dog and man. Xenobiotica 1982a; 12: 177–185
  • Eilertsen E., Magnussen M. P., Petersen H. J., Rastrup-Andersen N., Sørensen H., Arrigoni-Martelli E. Metabolism of the new antihypertensive agent pinacidil in rat, dog and man. Xenobiotica 1982b; 12: 187–196
  • Kardel T., Hilden T., Carlsen J., Trap-Jensen J. N″-cyano-N-pyridyl-N′-1,2,2-trimethylpropylguanidine, a new vasodilating agent: acute effect on blood pressure and pharmacokinetics in hypertensive patients. Journal of Cardiovascular Pharmacology 1981; 3: 1002–1007
  • Nobuhira Y., Hirano S., Nakanishi Y. Enantiomeric resolution of 1-[2-(3-hydroxyphenyl)-1-phenylethyl]-4-(3-methyl-2-butenyl)piperazine by reversed-phase high-performance liquid chromatography using a chiral mobile phase. Journal of Chromatography 1983; 258: 276–279
  • Petersen H. J., Nielsen C. K., Arrigoni-Marielli E. Synthesis and hypotensive activity of N-alkyl-N″-cyano-N′-pyridylguanidines. Journal of Medicinal Chemistry 1978; 21: 773–781
  • Sakamoto K., Nakamura Y. Urinary metabolites of pinacidil. I. Isolation and identification of the metabolites in rat urine. Xenobiotica 1993a; 23: 391–400
  • Sakamoto K., Nakamura Y. Urinary metabolites of pinacidil. II. Species difference in the metabolism of pinacidil. Xenobiotica 1993b; 23: 649–656
  • Weston A. H., Bray K. M., Duty S., McHarg A. D., Newgreen D. T., Southerton J. S. In vitro studies on the mode of action of pinacidil. Drugs 1988; 36: 10–28
  • Yamaoka K., Tanigawara Y., Nakagawa T., Uno T. A pharmacokinetic analysis program (MULTI) for microcomputer. Journal of Pharmacobio-Dynamics 1981; 4: 879–885

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.