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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 4
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Research Article

Prolonged presence of isoxsuprine in equine serum after oral administration

G. Pompa Institute of Veterinary Pharmacology and Toxicology, University of Milan, via Celoria 10, Milan, Italy
,
F. Caloni Institute of Veterinary Pharmacology and Toxicology, University of Milan, via Celoria 10, Milan, Italy
,
M. Montana Antidoping Centre, Jockey Club Italiano, via E. Montale 13, Milan, Italy
&
C. Pasqualucci Antidoping Centre, Jockey Club Italiano, via E. Montale 13, Milan, Italy
Pages 339-346 | Received 05 Aug 1993, Published online: 22 Sep 2008

References

  • Ashelford P. J., Wise S. D. Determination of plasma and urine concentration of isoxsuprine by HPLC in horses treated with circulon. Proceedings of the 5th International Conference on Control of Use of Drugs in Race Horses,Toronto,1983, G. H. Johnston. Canadian Section Association of Official Racing Chemists, Vol. 1: 179–184
  • Brambilla G., Montana M., Manca F., Marchisio A., Gulden P., Pompa G. Illegal use of isoxsuprine in animal productions: ELISA screening and MS/MS confirmation on bovine plasma and urine. Proceedings of the 3rd World Congress Foodborne Infections and Toxicants,Berlin,1992. FAO/WHO Collaborating Centre For Research and Training In Food Hygiene and Zoonoses, Vol. 2: 1282–1285
  • Dumasia M. C. The biotransformation and detection of some β-adrenergicmimetic drugs in the horse. Proceeding of the 9th International Conference of Racing Analysts and Veterinarians,New Orleans,1992, C. R. Short. International Conference of Racing Analysts and Veterinarians, Vol. 1: 75–90
  • Hashem A., Lubczyk B. Determination of isoxsuprine in equine plasma by high-performance liquid chromatography with electrochemical detection. Journal of Chromatography 1991; 563: 216–223
  • Korfmacher W. A., Freeman J. P., Hansen E. B., Holder C. L., Getek T. A. Characterization of the antihistamines tripelennamine, methapyrilene, and thenyldiamine and their N-oxides by thermospray mass spectrometry. Journal of Analytical Toxicology 1989; 13: 94–96
  • Kristoffersson J., Svensson L. A., Tenger K. Drug latentiation of terbutaline. Acta Pharmacologica Suecica 1974; 11: 427–438
  • Matthews N. S., Gleed R. D., Short C. E., Burrows K. Cardiovascular and pharmacokinetic effect of isoxsuprine in the horse. American Journal Veterinary Research 1986; 47: 2130–2133
  • Rose R. J., Allen J. R., Hodgson D. R. Studies on isoxsuprine hydrochloride for the treatment of navicular disease. Equine Veterinary Journal 1983; 15: 238–243
  • Sams R. Pharmacokinetics and urine to plasma drug concentration relationships in horses. Proceeding of the 9th International Conference of Racing Analysts and Veterinarians,New Orleans,1992, C. R. Short. International Conference of Racing Analysts and Veterinarians, Vol. 1: 179–199
  • Wilson J. H. G., Bochuis L. Controlled clinical studies in Europe with isoxsuprine hydrochloride for the treatment of navicular disease and sesamoidosis in horses. Irish Veterinary Journal 1986; 40: 10–12

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