Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 11
Submit an article Journal homepage
17
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Isolation and identification of seven metabolites of a water-soluble platelet aggregation inhibitor in rat urine

M. Tanaka Drug Metabolism and Analytical Chemistry Research Center, Developmental Research Laboratories, Daiichi Pharmaceutical Co. Ltd, 1–16–13 Kitakasai, Edogawa-ku, Tokyo, 134, Japan
,
F. Ishikawa Drug Metabolism and Analytical Chemistry Research Center, Developmental Research Laboratories, Daiichi Pharmaceutical Co. Ltd, 1–16–13 Kitakasai, Edogawa-ku, Tokyo, 134, Japan
&
H. Hakusui Drug Metabolism and Analytical Chemistry Research Center, Developmental Research Laboratories, Daiichi Pharmaceutical Co. Ltd, 1–16–13 Kitakasai, Edogawa-ku, Tokyo, 134, Japan
Pages 1247-1257 | Received 05 Jun 1995, Published online: 22 Sep 2008

References

  • Beverung W. N., Partyka A. US Patent. 3 932 407, 1976, [Chem. Abstr., 84 105646c 1976]
  • Caldwell J., Marsh M. V. Interrelationships between xenobiotic metabolism and lipid biosynthesis. Biochemical Pharmacology 1983; 32: 1667–1672
  • Holsztynska E. J., Domino E. F. Biotransformation of phencyclidine. Drug Metabolism Reviews 1986; 16: 285–320
  • Ishikawa F., Saegusa J., Inamura K., Sakuma K., Ashida S. Cyclic guanidines. 17. Novel (N-substituted amino)imidazo[2,1-b]quinazolin-2-ones; water-soluble platelet aggregation inhibitors. Journal of Medicinal Chemistry 1985; 28: 1387–1393
  • Kissinger P. T. Biomedical application of liquid chromatography-electrochemistry. Journal of Chromatography 1989; 488: 31–52
  • Kissinger P. T., Bratin K., Davis G. C., Pachla L. A. The potential utility of pre- and post-column chemical reactions with electrochemical detection in liquid chromatography. Journal of Chromatographic Science 1979; 17: 137–146
  • Lunte S. M., Kissinger P. T. Detection and identification of sulfhydryl conjugates of p-benzoquinone in microsomal incubations of benzene and phenol. Chemico-Biological Interactions 1983; 47: 195–212
  • Lunte S. M., Radzik D. M., Kissinger P. T. An introduction to the study of xenobiotic metabolism using electroanalytical techniques. Journal of Pharmaceutical Sciences 1990; 79: 557–567
  • Sekine Y., Miyamoto M., Hashimoto M., Nakamura K. Metabolism in rats and man of piromidic acid, a new antibacterial agent. Xenobiotica 1976; 6: 185–198
  • Tanaka M., Yamada M., Ono K., Takegoshi T. Determination of 7-piperidino-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one (DN-9693) in human plasma and urine by high-performance liquid chromatography with electrochemical detection: application to studies on disposition of DN-9693 in healthy human volunteers. Journal of Pharmaceutical Sciences 1987; 76: 235–237
  • Yamada J., Itoh S., Horie S., Watanabe T., Suga T. Chain-shortening of a xenobiotic acyl compound by the peroxisomal β-oxidation system in rat liver. Biochemical Pharmacology 1986; 35: 4363–4368

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.