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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 1
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Research Article

Relationship between hydrocarbon structure and induction of P450: effect on RNA levels

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Pages 9-16 | Received 26 May 1994, Published online: 22 Sep 2008

References

  • Adesnik M., Bar-Nun S., Maschio F., Zunich M., Lippman A., Bard E. Mechanism of induction of cytochrome P450 by phenobarbital. Journal of Biological Chemistry 1981; 256: 10340–10345
  • Atchison M., Adesnik M. A cytochrome P450 multigene family. Characterization of a gene activated by phenobarbital administratin. Journal of Biological Chemistry 1983; 258: 11285–11295
  • Backes W. L., Sequeira D. J., Cawley G. S., Eyer C. S. Relationship between hydrocarbon structure and induction of P450: effects on protein levels and enzyme activities. Xenobiotica 1993; 23: 1353–1366
  • Bandiera S. Expression and catalysis of sex-specific cytochrome P450 isozymes in rat liver. Canadian Journal of Physiology and Pharmacology 1990; 68: 762–768
  • Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 1987; 162: 156–159
  • Dannan G. A., Guenferich F. P., Waxman D. J. Hormonal regulation of rat liver microsomal enzymes. Roles of gonadai steroids in programming, maintenance, and suppression of delta 4-steroid 5 alpha-reductase, flavin-containing monooxygenase and sex-specific cytochrome P450. Journal of Biological Chemistry 1986; 261: 10728–10735
  • Elovaara E., Engstrom K., Vainio H. Metabolism and disposition of simultaneously inhaled m-xylene and ethylbenzene in the rat. Toxicology and Applied Pharmacology 1984; 75: 466–478
  • Friedberg T., Grassow M. A., Oesch F. Selective detection of mRNA forms encoding the major phenobarbital inducible cytochrome P450 and other members of the P450 IIB family by RNAse A protection assay. Archives of Biochemistry and Biophysics 1990; 279: 167–173
  • Gonzalez F. J. The molecular biology of cytochrome P450s. Pharmacological Review 1989; 40: 243–288
  • Gonzalez F. J. Molecular genetics of the P-450 superfamily. Pharmacological Therapeutics 1990; 45: 1–38
  • Gonzalez F. J., Kasper C. B. Cloning of DNA complementary to rat liver NADPH-cytochrome c (P-450) oxidoreductase and cytochrome P450b mRNAs. Evidence that phenobarbital augments transcription of specific genes. Journal of Biological Chemistry 1982; 10: 5962–5968
  • Hardwick J. P., Gonzalez F. J., Kasper C. B. Transcriptional regulation of rat liver epoxide hydratase, NADPH-cytochrome P450 oxidoreductase, and cytochrome P450 by phenobarbital. Journal of Biological Chemistry 1983; 258: 8081–8085
  • Imaoka S., Funae Y. Induction of cytochrome P450 isozymes in rat liver by methyl n-alkyl ketones and n-alkylbenzenes. Effects of hydrophobicity of inducers on inducibility of cytochrome P450. Biochemical Pharmacology 1991; 42: S143–150
  • Johannson I., Ekstrom G., Scholte B., Puzycki D., Jornvall H., Ingelman-Sundberg M. Ethanol-, fasting-, and acetone-inducible cytochrome P450 in rat liver: regulation and characteristics of enzymes belonging to the II B and II E gene subfamilies. Biochemistry 1988; 27: 1925–1934
  • Kim S. G., Novak R. F. Induction of rat hepatic P450 IIE1 (CYP 2E1) by pyridine: evidence for a role of protein synthesis in the absence of transcriptional activation. Biochemical and Biophysical Research Communications 1990; 166: 1072–1079
  • Koop D. R., Crump B. L., Nordblom G. D., Coon M. J. Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, actetone, pyrazole, and isoniazid. Proceedings of the National Academy of Sciences, USA 1985; 82: 4065–4069
  • Koop D. R., Laethem C. L., Schinier G. G. Identification of ethanol-inducible P450 isozyme 3a (P450IIE1) as a benzene and phenol hydroxylase. Toxicology and Applied Pharmacology 1989; 98: 278–288
  • Koop D. R., Tierney D. J. Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1. BioEssays 1990; 12: 429–435
  • Laskey R. A., Mills A. D. Enhanced autoradiographic detection of 32P and 125I using intensifying screens and hypersensitized film. FEBS Letters 1977; 82: 314–316
  • Maniatis T., Fritisch E. F., Sambrook J. Agarose gel electrophoresis. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, New York 1982; 150–172
  • Mode A., Wiersma-Larsson E., Gustafsson J. A. Transcriptional and post-transcriptional regulation of sexually differential rat liver cytochrome P450 by growth hormone. Molecular Endocrinology 1989; 3: 1142–1147
  • Morgan E. T., MacGeoch C., Gustafsson J. Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16a-hydroxylase cytochrome P450 apoprotein in the rat. Journal of Biological Chemistry 1985; 260: 11895–11898
  • Okey A. B. Enzyme induction in the cytochrome P450 system. Pharmacological Therapeutics 1990; 45: 241–298
  • Omiecininski C. J., Walz F. G., Vlasuk G. P. Phenobarbital induction of rat liver cytochromes P450b and P450e. Journal of Biological Chemistry 1985; 260: 3247–3250
  • Pathiratne A., Puyear R. L., Brammer J. D. A comparative study of the effects of benzene, toulene, and xylenes on their in vitro metabolism and drug metabolizing enzymes in rat liver. Toxicology and Applied Pharmacology 1986; 82: 272–280
  • Pyykkö K. Effects of methylbenzenes on microsomal enzymes in rat liver kidney and lung. Biochimica et Biophysica Acta 1980; 633: 1–9
  • Saito F. U., Kocsis J. J., Snyder R. Effect of benzene on hepatic drug metabolism and ultrastructure. Toxicology and Applied Pharmacology 1973; 26: 209–217
  • Schuetz E. G., Schuetz J. D., May B., Guzelian P. S. Regulation of cytochrome P450 b/e and P450 p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. Journal of Biological Chemistry 1990; 265: 1188–1192
  • Sequeira D. J., Eyer C. S., Cawley G. F., Backes W. L. Temporal changes in P450 2E1 expression with continued ethylbenzene exposure. Biochimica et Biophysica Acta 1994; 1207: 179–186
  • Sequeira D. J., Eyer C. S., Cawley G. F., Nick T. G., Backes W. L. Ethylbenzene-mediated induction of cytochrome P450 isozymes in male and female rats. Biochemical Pharmacology 1992; 44: 1171–1182
  • Simmons D. L., McQuiddy P., Kasper C. B. Induction of the hepatic mixed-function oxidase system by synthetic glucocorticoids. Transcriptional and post-transcriptional regulation. Journal of Biological Chemistry 1987; 262: 326–332
  • Srivastava G., Hansen A. J., Bawden M. J., May B. K. Hemin administration to rats reduces levels of hepatic mRNAs for phenobarbitone-inducible enzymes. Molecular Pharmacology 1990; 38: 486–493
  • Toftgård R., Haaparanta T., Eng T., Halpert J. Rat lung and liver cytochrome P-450 isozymes involved in the hydroxylation of n-hexane. Biochemical Pharmacology 1986b; 35: 3733–3738
  • Toftgård R., Haaparanta T., Halpert J. Rat lung and liver cytochrome P-450 isozymes involved in the hydroxlylation of m-xylene. Toxicology 1986a; 39: 225–231
  • Wang R. S., Nakajima T., Park S. S., Gelboin H. V., Murayama N. Monoclonal antibody-directed assessment of toluene induction of rat hepatic cytochrome P450 isozymes. Biochemical Pharmacology 1993; 46: 413–419
  • Waxman D. J., Dannan G. A., Guengerich F. P. Regulation of rat hepatic cytochrome P450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isozymes. Biochemistry 1985; 24: 4409–4417
  • Yoshioka H., Morohashi K., Sogawa K., Miyata T., Kawajiri K., Hirose T., Inayama S., Fujii-Kuriyama Y., Omura T. Structural analysis and specific expression of microsomal cytochrome P450 (M-1) mRNA in male rat livers. Journal of Biological Chemistry 1987; 262: 1706–1711

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