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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 1
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Research Article

Sex-dependent and independent renal excretion of nilvadipine metabolites in rat: evidence for a sex-dependent active secretion in kidney

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Pages 37-47 | Received 14 Jul 1994, Published online: 22 Sep 2008

References

  • Arita T., Hori R., Qwada E., Takahashi K. Transformation and excretion of drugs in biological systems. 1. Renal excretion mechanisms of sulfonamides (1). Chemical and Pharmacological Bulletin 1969; 17: 2526–2532
  • Carter A. L., Stratman F. W. Sex steroid regulation of urinary excretion of carnitine in rats. Journal of Steroid Biochemistry 1982; 17: 211–215
  • Despopoulos A. A definition of substrate specificity in renal transport of organic anions. Journal of Theoretical Biology 1965; 8: 163–192
  • Hanhijarvi H., Ophaug R. H., Singer L. The sex-related difference in Perfluorooctanoate excretion in the rat (41476). Proceedings of the Society for Experimental Biology and Medicine 1982; 171: 50–55
  • Hewitt W. R., Hook J. B. The renal excretion of drugs. Progress in Drug Metabolism, J. W. Bridges, L. F. Chasseaud, 1983; vol. 7
  • Janssen F. W., Young E. M., Ruelius H. W. Effect of sex hormones on the disposition in rats of 1-aminocyclohexane carboxylic acid, a metabolite of a semisynthetic penicillin. Drug Metabolism and Disposition 1976; 4: 540–546
  • Mateos A. F., Garcia P. J., Ramos T., Gonzales P., Drdas J. Sex differences in uric acid metabolism in adults: evidence for a lack of influence of estradiol-17β (E2) on the renal handling of urate. Metabolism 1986; 35: 343–348
  • Moller J. V., Sheikh M. I. Renal organic anion transport system: pharmacological, physiological, and biochemical aspects. Pharmacology Review 1983; 34: 315–358
  • Nishida Y., Akaoka I., Nishizawa T. Fffect of sex hormones on uric acid metabolism in rats. Experientia 1975; 31: 1134–1135
  • Ohtuka M., Ono T., Hiroi J., Esumi K., Kikuchi H., Kumada S. Comparison of the cardiovascular effect of FR34235, a new dihydropyridine, with other calcium antagonists. Journal of Cardiovascular Pharmacology 1983; 5: 1074–1082
  • Rizzardini M., Smith A. G. Sex differences in the metabolism of hexachlorobenzene by rats and the development of porphyria in females. Biochemical Pharmacology 1982; 31: 3543–3548
  • Sabatini A., Vacca A., Gans P. MINIQUAD—a general computer programme for the computation of formation constants from potentiometric data. Talanta 1974; 21: 53–77
  • Smith A. G., Francis J. E. Evidence for the active renal secretion of S-pentachlorophenyl-N-acetyl-L-cyesteine by female rats. Biochemical Pharmacology 1983; 32: 3797–3801
  • Tanaka Y., Deguchi Y., Ishii I., Terai T. Sex difference in excretion of zenarestat in rat. Xenobiotica 1991; 21: 1119–1125
  • Tanaka Y., Fujiwara T., Esumi Y. Sex difference in the excretion of zenarestat in mouse, rat, dog and man. Xenobiotica 1992; 22: 941–947
  • Tanaka Y., Sawamoto T., Suzuki A., Kimura T. Pharmacokinetics of zenarestat, an aldose reductase inhibitor, in male and female diabetic rats. Drug Metabolism and Disposition 1993; 21: 677–681
  • Terakawa M., Tokuma Y., Shishido A., Noguchi H. Pharmacokinetics of nilvadipine in healthy volunteers. Journal of Clinical Pharmacology 1987; 27: 111–117
  • Terashita S., Tokuma Y., Fujiwara T., Shiokawa Y., Okumura K., Noguchi H. Metabolism of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs. Xenobiotica 1987; 17: 1415–1425
  • Terashita S., Tokuma Y., Sekiguchi M., Noguchi H. Sex difference in the metabolism and excretion of nilvadipine, a new dihydropyridine calcium antagonist in rat. Xexobiotica 1989; 19: 1221–1229
  • Tokuma Y., Fujiwara T., Noguchi H. Absorption, distribution and excretion of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs. Xenobiotica 1987; 17: 1341–1349
  • Tuji A., Yoshikawa T., Nishide K., Minami H., Kimura M., Nakashima E., Terasaki T., Miyamoto E., Nightingale C. H., Yamana T. Physiologically based pharmacoki-netic model for β-lactam antibiotics. I. Tissue distribution and elimination in rats. Journal of Pharmacological Science 1983; 72: 1239–1251
  • Waugh W. H. Photometry of inulin and polfructosan by use of a cystein/tryptophan reaction. Clinical Chemistry (New York) 1977; 23: 639–645
  • Weiner I. M., Washington J. A., II, Mudge G. H. On the mechanism of action of probenecid on renal tubular sectretion. Bulletin of the Johns Hopkins Hospital 1960; 106: 333–346

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