Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 3
7
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Influence of hypoxia and hypercapnia on the kinetics and hypokaliaemic effect of salbutamol in the rabbit

, , &
Pages 271-281 | Received 04 Jun 1994, Published online: 27 Aug 2009

References

  • Ahrens C., Haglund U. Mucosal lesions in the small intestine of the cat during low flow. Acta Physiologica Scandinavica 1973; 88: 541–550
  • Ahrens R. C., Smith G. D. Albuterol: an adrenergic agent for use in the treatment of asthma, pharmacology, pharmacokinetics and clinical use. Pharmacotherapy 1984; 4: 105–120
  • Anderson S. E., Murphy E., Steenbergen C. E., London R. E., Cala P. M. Na+-H+ exchange in myocardium: effects of hypoxia and acidification on Na+ and Ca2+. American Journal of Physiology 1990; 259: C940–948
  • Ashcroft S. J. H., Ashchoft F. M. Properties and functions of ATP-sensitive k-channels. Cellular Signalling 1990; 2: 197–214
  • Avery G. S. Respiratory Diseases. Drug Treatment, Principles and Practice of Clinical Pharmacology and Therapeutics, G. S. Avery. Adis, Sydney 1980; 476–490
  • Aw T. Y., Jones D. P. Control of glucuronidation during hypoxia. Limitation by UDP-glucose pyrophosphorylase. Biochemical Journal 1984; 219: 707–712
  • Bange C., Radziszewski E., Curé M., Guillerm R., Pérés G. Effect of long term hypercapnia on plasma amino acids in the rat. Tissular and Humoral Response to Hypercapnia, C. Saunier, F. Schrijen. Masson, Paris 1976; 165–176
  • Baron J., Voigt J. M. Localization, distribution and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within the lung. Pharmacology and Therapeutics 1990; 47: 419–445
  • Bond J. A., Harkema J. R., Russell I. Regional distribution of xenobiotic metabolising enzymes in respiratory airways of dogs. Drug Metabolism and Disposition 1988; 16: 116–124
  • Block E. R., Patel J. M., Edwards D. A. Mechanism of hypoxia injury to pulmonary artery endothelial cell plasma membranes. American Journal of Physiology 1989; 257: c223–231
  • Clausen T., Van Hardeveld C., Everts M. E. Significance of cation transport in control of energy metabolism and thermogenesis. Physiological Reviews 1991; 71: 733–774
  • Coleman S. E., Duggan B. S., Hackett R. L. Plasma membrane changes in freeze-fractured rat kidney cortex following renal ischemia. Laboratory Investigation 1976; 35: 63–70
  • Du Souich P., Clozel J. P., Saunier C., Hartemann D., Schrijen F., Amend P. The influence of hypoxemia on tritiated digoxin plasma kinetics and tissue distribution in the conscious dog. American Review of Respiratory Disease 1985; 132: 504–509
  • Du Souich P., McLean A. J., Lalka D., Erill S., Gibaldi M. Pulmonary disease and drug kinetics. Clinical Pharmacokinetics 1978; 3: 257–266
  • Du Souich P., Saunier C., Harteman D., Allam M. Effect of acute and chronic moderate hypoxia on the kinetics of lidocaine and its metabolites and on regional blood flow. Pulmonary Pharmacology 1992; 5: 9–16
  • Du Souich P., Varin F., Courteau H. Effect of hypercapnia and/or hypoxemia and metabolic acidosis on kinetics and concentrations of phenytoin in the cerebrospinal fluid of conscious rabbits. Neuropharmacology 1986; 25: 857–862
  • Dutton R., Levitzky M., Berkman R. Carbon dioxide and liver blood flow. Bulletin of European Physiopathology and Respiration 1976; 12: 265–272
  • Erickson R. R., Yu-Drent P., Holtzman J. L. The kinetics of ethylmorphine N-demethylase in isolated hepatocytes: the effect of drug transport and oxygen concentration. Journal of Pharmacology and Experimental Therapeutics 1982; 220: 35–38
  • Evans M. E., Paterson J. W., Shenfield G. M. A technique for studying drug absorption from the lung in man. British Journal of Pharmacology 1973; 49: 153–156
  • Gibaldi M., Perrier D. Multicompartmental models. Pharmacokinetics, J. Swarbrick. Marcel Decker, New York 1982; 45–111
  • Gram T. E., Litters T. C. L., Mimnough E. G. Enzymatic conjugation of foreign chemical compounds by rabbits lung and liver. Drug Metabolism and Disposition 1974; 2: 254–258
  • Gresser H., Poupa O. Relationship between glucose and Ca2+ fluxes under anoxia and acidosis in resting cardiac cell of rat. Acta Physiologica Scandinavica 1982; 114: 303–305
  • Guengerich F. P. Purification and characterization of xenobiotic-metabolizing enzymes from lung tissue. Pharmacology and Theraprutics 1990; 45: 299–308
  • Harper M. A. Physiology of cerebral blood flow. British Journal of Anaesthesia 1965; 37: 225–235
  • Holtzman J. L., Gander J. E., Erickson R. R. The effect of NADH and low oxygen pressure on the hepatic microsomal ethylmorphine N-demethylase activity of the male rat. Journal of Biological Chemistry 1983; 258: 5400–5404
  • Hughes J. M. B. Lung gas tensions and active regulation of ventilation/perfusion ratios in health and disease. British Journal of Diseases of the Chest 1975; 69: 153–170
  • Hughes R. L., Mathie R. T., Campbell D., Fitch W. Effect of hypercapnia on hepatic blood flow and oxygen consumption in the greyhound. British Journal of Anaesthesia 1979; 51: 289–296
  • Jagadeesh G., Das P. K. Beta-adrenoceptors in intestine, atria and trachea of rabbit. Indian Journal of Medical Research 1981; 75: 311–321
  • Jones D. P., Aw T. W., Shan X. Drug metabolism and toxicity during hypoxia. Drug Metabolism and Reviews 1989; 20: 247–260
  • Kendrick J. E., DeHaan S. J., Parke J. D. Regulation of blood flow to respiratory muscles during hypoxia and hypercapnia. Proceedings of the Society for Experimental Biology and Medicine 1981; 166: 157–161
  • Koster A., Hofman G. A., Frankhuijzen-Sierevogel C., Noordhoek J. Presystemic and systemic intestinal metabolism of fenoterol in the conscious rat. Drug Metabolism and Disposition 1985; 13: 464–470
  • Kelly H. W., Smith G. D. Asthma. Applied Therapeutics, B. S. Katcher, L. Y. Young, M. A. Koda-Kimble. Applied Therapeutics, San Francisco 1989; 361–391
  • Lai Y. L., Atteberg B. A., Brown L. B. Intracellular adjustments of skeletal muscle, heart and brain to prolonged hypercapnia. Respiration Physiology 1973; 19: 115–122
  • Lemasters J. L., Stemkowski C. J., Sungchul J. L., Thurman R. G. Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated perfused rat liver. Journal of Cell Biology 1983; 97: 778–786
  • Letarte L., Du Souich P. Influence of hypercapnia and/and or hypoxemia and metabolic acidosis on theophylline kinetics in the conscious rabbits. American Review of Respiratory Disease 1984; 129: 762–766
  • Lucier G. W., Sovawane B. R., McDanlel O. S. Glucuronidation and deglucuronidation reactions in hepatic and extrahepatic tissues from perinatal development. Drug Metabolism and Disposition 1977; 5: 279–287
  • Lulich K. M., Goldie R. G., Paterson J. W. Adverse reactions to β2-agonist bronchodilators. Medical Toxicology 1986; 1: 286–299
  • Lungren O., Haglund U. The pathophysiology of the intestine counter-current exchanger. Life Science 1978; 23: 1411–1422
  • Marleau S., Ong H., Gariépy L., Du Souich P. Lidocaine and indocyanine green kinetics: effect of hypoxia and/or hypercapnia. Journal of Pharmacology and Experimental Therapeutics 1987; 242: 338–343
  • Martin L. E., Hobson J. C., Page J. A., Harrison C. Metabolic studies of 3H-salbutamol: a new bronchodilator in rats, rabbit, dog and man. European Journal of Pharmacology 1971; 14: 183–199
  • McFadden E. R., Gilbert I. A. Asthma. New England Journal of Medicine 1992; 27: 1928–1937
  • Morgan D. J., Paull J. D., Richmond B. H., Wilson-Evered E., Ziccone S. P. Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate. British Journal of Clinical Pharmacology 1986; 22: 587–593
  • Mudge G. H., Weiner I. M. Agents affecting volume and composition of body fluids. Goodman and Gilman's, The Pharmacological Basis of Therapeutics, A. G. Gilman, T. W. Rall, A. S. Nies, P. Taylor. Pergamon, New York 1990; 682–702
  • Nahas G. G. Metabolic and endocrine repercussions of hypercapnia. Tissular and Humoral Response to Hypercapnia, C. Saunier, F. Schrijen. Masson, Paris 1976; 150–164
  • Nakahata N., Takagi Y., Watanabe E., Suzuki T. Adrenergic β1- and β2-receptors in the isolated rabbit jejunum and ileum. Fukushima Journal of Medical Science 1978; 25: 121–130
  • Park R., Leach W. J., Arieff A. I. Determination of liver intracellular pH in vivo and its homeostasis in acute acidosis and alkalosis. American Journal of Physiology 1979; 236: F240–245
  • Perreault S., Dumont L., Villières V., Ong H., Adam A., Du Souich P. Hepatic and extrahepatic metabolism of salbutamol in anaesthetized rabbits. Drug Metabolism and Disposition 1993; 21: 485–491
  • Perreault S., Ong H., Du Souich P. Salbutamol disposition in conscious rabbits: influence of the route of administration and of the dose. Journal of Pharmacokinetic and Biopharmaceutic 1991; 20: 461–476
  • Poole-Wilson P. A., Tones M. A. Sodium exchange during hypoxia and on reoxygenation in the isolated rabbit heart. Journal of Molecular and Cellular Cardiology 1988; 20: 15–22
  • Robinson J. W. L., Mirkovitch V. The roles of intraluminal oxygen and glucose in the protection on the rat intestinal mucosa from the effects of ischemia. Biomedicine 1977; 27: 60–62
  • Rohr A. S., Sheldon L., Rachelefsky G. S., Kkatz M., Siegel S. C. Efficacy of parenteral albuterol in the treatment of asthma, comparison of its metabolic side effects with subcutaneous epinephrine. Chest 1986; 89: 348–256
  • Roth R. A. The lungs and metabolic drug clearance in health and disease. Pharmacokinetic Basis for Drug Treatments, L. Z. Benet, N. Massoud, J. G. Gambertoglio. Raven, New York 1984; 105–117
  • Roth R. A., Rubin R. J. Role of blood flow in carbon monoxide- and hypoxic-induced alterations in hexobarbital metabolism in rats. Drug Metabolism and Disposition 1976; 4: 460–467
  • Rowell L. B., Blackmon R. J. Human cardiovascular adjustments to acute hypoxaemia. Clinical Physiology 1987; 7: 349–376
  • Shenfield G. M., Evans M. E., Paterson J. W. The effect of different nebulizers with and without intermittent positive pressure breathing on the absorption and metabolism of salbutamol. British Journal of Clinical Pharmacology 1974; 1: 295–300
  • Shute K. Effect of intraluminal oxygen on experimental ischemia of the intestine. Gut 1976; 17: 1001–1006
  • Spitzer W. O., Suissa S., Ernst P., Hornitz R. I., Habbick B., Cockcroft D., Boivin J. F., McNutt M., Buist S., Reback A. The use of β-agonists and the risk of death and near death from asthma. New England Journal of Medicine 1992; 326: 501–506
  • Stubbs C. D., Smith A. D. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochemical and Biophysical Acta 1984; 779: 89–134
  • Tsuru M., Erickson R. R., Holtzman J. L. The metabolism of phenytoin by isolated hepatocytes and hepatic microsomes from male rats. Journal of Pharmacology and Experimental Therapeutics 1982; 222: 658–661
  • Vance J. P., Smith G., Brown D. M., Thoburn J. Response of mean and phasic coronary arterial blood flow to graded hypercapnia in dogs. British Journal of Anaesthesia 1979; 51: 523–529
  • Vick R. L., Todd E. P., Luerke D. W. Epinephrine-induced hypoaliaemic relation to liver and skeletal muscle. Journal of Pharmacology and Experimental Therapeutics 1972; 181: 139–146
  • Winer B. J. Statistical Principles in Experimental Design. Mc-Graw Hill, New York 1974; 201–204

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.