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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 3
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Original Article

N+ -Glucuronidation of aliphatic tertiary amines in human: antidepressant versus antipsychotic drugs

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Pages 291-301 | Received 06 Aug 1994, Published online: 27 Aug 2009

References

  • Becher B., Fischer W., Taneri Z., Scholz E., Müller W. E., Breyer-Pfaff U. Urinary metabolites of amitriptylinoxide and amitriptyline in single dose experiments and during continuous therapy. Psychopharmacology 1992; 106: 303–310
  • Breyer-Pfaff U., Becher B., Nusser E., Nill K., Baier-Weber B., Zaunbrecher D., Wachsmuth H., Prox A. Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine. Xenobiotica 1990; 20: 727–738
  • Chaudhary A. K., Hubbard J. W., McKay G., Midha K. K. Identification of a quaternary ammonium-linked glucuronide of chlorpromazine in the urine of a schizophrenic patient treated with chlorpromazine. Drug Metabolism and Disposition 1988; 16: 506–508
  • Coughtrie M. W. H., Sharp S. Glucuronidation of imipramine in rabbit and human liver microsomes: assay conditions and interaction with other tertiary amine drugs. Biochemical Pharmacology 1991; 42: 1497–1501
  • Dahl-Puustinen M.-L., Bertilsson L. Formation of a quaternary N-glucuronide of amitriptyline in human liver microsomes. Pharmacology and Toxicology 1987; 61: 342–346
  • Dahl-Puustinen M.-L., Åberg-Wistedt A., Bertilsson L. Glucuronidation of amitriptyline in man in vivo. Pharmacology and Toxicology 1989; 65: 37–39
  • Delbressine L. P. C., Moonen M. E. G., Kaspersen F. M., Jacobs P. L., Wagenaars G. L. Biotransformation of mianserin in laboratory animals and man. Xenobiotica 1992; 22: 227–236
  • Dleterle W., Faigle J. W., Mory H. Preparative reversed-phase chromatography of polar and non-polar metabolites on columns packed with micronized XAD-2 resin. Journal of Chromatography 1979; 168: 27–34
  • Mucker H. B., Stauffer S. C., Balletto A. J., White S. D., Zacchei A. G., Arison B. H. Physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey, and man. Drug Metabolism and Disposition 1978; 6: 659–672
  • Jørgensen A. Metabolism and pharmacokinetics of antipsychotic drugs. Progress in Drug Metabolism, vol. 9, J. W. Bridges, L. F. Chasseaud. Taylor & Francis, London 1986; 111–174
  • Kawahara K., Awaji T., Uda K., Sakai Y., Hashimoto Y. Urinary excretion of conjugates of dothiepin and northiaden (mono-N-demethyldothiepin) after an oral dose of dothiepin to humans. European Journal of Drug Metabolism and Pharmacokinetics 1986; 11: 29–32
  • Korolkovas A. Psychopharmacologicals. Essentials of Medicinal Chemistry. 2nd edn. Wiley, New York 1988; 284–328
  • Lehmax J. P., Fenselau C. Synthesis of quaternary mmonium-linked glucuronides by rabbit hepatic microsomal UDP-glucuronyltransferase and analysis by fast-atom bombardment mass spectrometry. Drug Metabolism and Disposition 1982; 10: 446–449
  • Lehman J. P., Fenselau C., Depaulo J. R. Quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine. Drug Metabolism and Disposition 1983; 11: 221–225
  • Luo H., Hawes E. M., McKay G., Korchinski E. D., Midha K. K. The quaternary ammonium-linked glucuronide of doxepin: a major metabolite in depressed patients treated with doxepin. Drug Metabolism and Disposition 1991a; 19: 722–724
  • Luo H., Hawes E. M., McKay G., Korchinski E. D., Midha K. K. N+-Glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H1-antihistamines in humans. Xenobiotica 1991b; 21: 1281–1288
  • Luo H., Hawes E. M., McKay G., Midha K. K. Synthesis and characterization of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine group. Journal of Pharmaceutical Sciences 1992; 81: 1079–1083
  • Stycznski P. B., Green M. D., Coffman B., Tephly T. R. Studies on tertiary amine UDP-glucuronosyltransferases from human and rabbit hepatic microsomes. Drug Metabolism and Disposition 1992; 20: 896–901

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