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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 4
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Research Article

Kinetics of ranitidine metabolism in dog and rat isolated hepatocytes

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Pages 367-375 | Received 13 Jul 1994, Published online: 22 Sep 2008

References

  • Bayliss M. K., Bell J. A., Wilson K., Park G. R. 7-Ethoxycoumarin O-deethylase kinetics in isolated rat, dog and human hepatocyte suspensions. Xenobiotica 1994; 24: 231–241
  • Bell J. A., Dallas F. A. A., Jenner W. N., Martin L. E. The metabolism of ranitidine in animals and man. Biochemical Society Transactions 1980; 8: 93
  • Boobis A. R., Kahn G. C., Whyte C., Brodie M. J., Davis D. S. Biphasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractions. Biochemical Pharmacology 1981; 30: 2451–2456
  • Carey P. F., Martin L. E., Evans M. B. High performance liquid chromatographic methods for the determination of ranitidine and its metabolites in biological fluids. Chromatographia 1984; 19: 200–205
  • Chenery R. J. The utility of hepatocytes in drug metabolism studies. Progress in Drug Metabolism, G. G. Gibson. Taylor & Francis, London 1988; 217–265
  • Cross D. Isolated hepatocytes as a model for ranitidine metabolism: in vivo and in vitro correlations in the rat, dog and guinea-pig. University of Hertfordshire. 1991, PhD thesis
  • Gee S. J., Green C. E., Tyson C. A. Comparative metabolism of tolbutamide by isolated hepatocytes from rat, rabbit, dog and squirrel monkey. Drug Metabolism and Disposition 1984; 12: 174–178
  • Green C. E., Le Valley S. E., Tyson C. A. Comparison of amphetamine metabolism using isolated hepatocytes from five species including human. Journal of Pharmacological and Experimental Therapeutics 1986; 237: 931–936
  • Jauregui H. O., Hayner N. T., Driscoll J. L., Williams-Holland R., Lipsky M. H., Galletti P. M. Trypan blue type uptake and lactate dehydrogenase release in adult rat hepatocytes—freshly isolated cells, cell suspensions and primary monolayer cultures. In vitro 1981; 17: 1100–1110
  • Martin L. E., Bell J. A., Carey P. F., Dallas F. A. A., Dixon G. T., Jenner W. N. A review of pharmokinetics and metabolism of ranitidine in animals and man. The Clinical Use of Ranitidine. Medicine Publishing Foundation, Oxford 1982a; 23–31
  • Martin L. E., Oxford J., Tanner R. J. N. Use of high performance liquid chromatography—mass spectrometry for the study of the metabolism of ranitidine in man. Journal of Chromatography 1982b; 251: 215–224
  • McCormick D. J., Fitzgerald T. C., McKillop D. The metabolism of propranolol (ICI 45,520, Inderal™) and xamoterol (ICI 118,587, Corwin™) by isolated rat hepatocytes: in vivo—in vitro correlations. Xenobiotica 1988; 18: 1407–1412
  • Morais J. A., Wagner J. G. Steroid metabolism in isolated rat hepatocytes. European Journal of Drug Metabolism and Pharmacokinetics 1985; 10: 295–307
  • Oldham H. G., Chenery R. J. Interaction of cimetidine and ranitidine with the FAD monooxygense in pig liver microsomes. Biochemical Pharmacology 1985; 34: 2398–2401
  • Omura T., Sato R. The carbon monoxide binding pigment of liver microsomes. I. Evidence for its heamoprotein nature. Journal of Biological Chemistry 1964; 239: 2370–2378
  • Ortiz de Montellaxo P. R., Matthews J. M. Autocatalytic alkylation of cytochrome P450 prosthetic haem group by 1-aminobenzotriazole. Biochemical Journal 1981; 195: 761–764
  • Rogiers V., Adriaenssens L., Vandenberghe Y., Gepts E., Callaerts A., Vercruysse A. Critical evaluation of 7-ethoxycoumarin O-deethylase activity measurement in intact isolated rat hepatocytes. Xenobiotica 1986; 16: 817–826
  • Rowland M. Physiologic pharmacokinetic models and interanimal species scaling. Pharmacology and Therapeutics 1985; 29: 49–68
  • Saxins S. M., Adams W. J., Kaiser D. G., Halstead G. W., Baillie T. A. Studies on the metabolism and chiral inversion of ibuprofen in isolated rat hepatocytes. Drug Metabolism and Disposition 1990; 18: 527–533
  • Seddox T., Michelle I., Chenery R. J. Comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog. Biochemical Pharmacology 1989; 38: 1657–1665
  • Sedmark J. J., Grossberg S. E. A rapid, sensitive and versatile assay for protein using Coomassie brilliant blue G250. Analytical Biochemistry 1977; 79: 544–552
  • Seglen P. O. Preparation of isolated rat liver cells. Methods in Cell Biology, D. M. Prescott. Academic, New York 1976; 18: 31–83
  • Tatsumi K., Kitamura S., Yamapa H. Sulfoxide reductase activity of liver aldehyde oxidase. Biochimica et Biophysica Acta 1983; 747: 86–92
  • von Bahr C., Vadi H., Grundin R., Moldeus P., Orrenius S. Spectral studies on the rapid uptake and subsequent binding of drugs to cytochrome P-450 in isolated rat liver cells. Biochemical and Biophyical Research Communications 1974; 59: 334–339
  • Warner M., La Marca M. V., Neims A. H. Chromatographic and electrophoretic heterogeneity of the cytochrome P450 solubilized from untreated rat liver. Drug Metabolism and Disposition 1978; 6: 353–362
  • Zeldis J. B., Friedman L. S., Isselbacher K. J. Ranitidine: a new H2-receptor antagonist. New England Journal of Medicine 1983; 309: 1368–1373
  • Ziegler D. M. Flavin-containing monooxygenases: catalytic mechanism and substrate specificities. Drug Metabolism Reviews 1988; 19: 1–32

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