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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 5
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Original Article

Small intestinal sulphoxidation of Albendazole

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Pages 433-441 | Received 06 Aug 1994, Published online: 27 Aug 2009

References

  • Cook G. C. Use of benzimidazole chemotherapy in human helminthiases: indications and efficacy. Parasitology Today 1990; 6: 133–137
  • Dawson J. R., Schwenk M. Isolated epithelial cells. Progress in Pharmacology and Clinical Pharmacology 1989; 7: 21–41
  • Delatour P., Benoit F., Garnier F., Besse S. Chirality of the sulphoxide metabolites of fenbendazole and Albendazole in sheep. Journal of Veterinary Pharmacology and Therapeutics 1990; 13: 361–366
  • Dubey R. K., Singh J. Localization and characterization of drug metabolizing enzymes along the villus-crypt surface of the rat small intestine. I. Biochemical Pharmacology 1988; 37: 169–176
  • Fargetton X., Galtier P., Delatour P. Sulfoxidation of Albendazole by a cytochrome p450-independent monooxigenase from rat liver microsomes. Veterinary Research Communications 1986; 10: 317–324
  • Friedberg T., Siegert P., Grassow M. A., Bartlomowicz B., Oesch F. Studies of the expression of the cytochrome P450IA, P450IIB, and P450IIC gene family in extrahepatic and hepatic tissues. Environmental Health Perspectives 1990; 88: 67–90
  • Galtier P., Alvinerie M. S., Delatour P. In vitro sulfoxidation of Albendazole by ovine liver microsomes: assay and frequency of various xenobiotics. American Journal of Veterinary Research 1986; 47: 447–450
  • Galtier P., Alvinerie M., Steimer J. L., Francheteau P., Plusquellec Y., Houin G. Simultaneous pharmacokinetic modeling of a drug and two metabolites: application to Albendazole in sheep. Journal of Pharmaceutical Sciences 1991; 80: 3–10
  • Gil-Grande L. A., Rodriguez-Caabeiro F., Prieto J. G., Sanchez Ruano J. J., Brasa C., et al. Randomised controlled trial of efficacy of albendazole in intra-abdominal hydatid disease. Lancet 1993; 342: 1269–1272
  • Gottschall D. W., Thedorides V. J., Wang R. The metabolism of benzimidazole anthelmintics. Parasitology Today 1990; 6: 118–124
  • Harmsworth W. L., Franklin M. R. Induction of hepatic and extrahepatic cytochrome P-450 and monooxigenase activities by N-substituted imidazoles. Xenobiotica 1990; 20: 1053–1063
  • Kaminsky L. S., Fasco M. J. Small intestinal cytochromes P450. Critical Reviews in Toxicology 1992; 21: 407–422
  • Klee S., Langen B., Galtier P., Ungemach F. R. Studies on intestinal cytochrome P450 isozymes in rats, guinea-pigs and pigs. Proceedings of the Sixth International Congress of Veterinary Pharmacology and Toxicology. Blackwell, Oxford 1994; 36
  • Kolars J. C., Awni W. N., Merion R. M. First-pass metabolism of cyclosporin by the gut. Lancet 1991; 338: 1488–1490
  • Lanusse C., Nare B., Gascon L. H., Prichard R. K. Metabolism of Albendazole and Albendazole sulphoxide by ruminal and intestinal fluids of sheep and cattle. Xenobiotica 1992; 22: 419–426
  • Lanusse C. E., Prichard R. K. Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants. Drug Metabolism Reviews 1993; 25: 235–279
  • Lanusse C. E., Nare B., Prichard R. K. Comparative sulphoxidation of Albendazole by sheep and cattle liver microsomes and the inhibitory effect of methimazole. Xenobiotica 1993; 23: 285–295
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with Folin reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Murray M., Hudson A. M., Yassa V. Hepatic microsomal metabolism of the anthelmintic benzimidazole Fenbendazole: enhanced inhibition of cytochrome P450 reactions by oxidized metabolites of the drug. Chemical Research in Toxicology 1992; 5: 60–66
  • Rolin S., Souhaili-El Amri H., Batt A. M. Study of the in vitro bioactivation of Albendazole in human liver microsomes and hepatoma cell lines. Cell Biology and Toxicology 1989; 5: 1–14
  • Shirkey R. J., Chakraborty J., Bridges J. W. An improved method for preparing rat small intestine microsomal fractions for studying drug metabolism. Analytical Biochemistry 1979; 93: 73–81
  • Short C. R., Flory W., Hsieh L. C., Barker S. A. The oxidative metabolism of fenbendazole: a comparative study. Journal of Veterinary Pharmacology and Therapeutics 1988; 11: 50–55
  • Souhaili-El Amri H., Fargetton X., Delatour P., Batt A. M. Sulfoxidation of Albendazole by the FAD-containing and cytochrome P-450 dependent mono-oxigenases from pig liver microsomes. Xenobiotica 1987; 17: 1159–1168
  • Souhaili-El Amri H., Fargetton X., Benoit E., Totis M., Batt A. M. Inducing effect of Albendazole on rat liver drug-metabolizing enzymes and metabolite pharmacokinetics. Toxicology and Applied Pharmacology 1988a; 92: 141–149
  • Souhaili-El Amri H., Mothe O., Totis M., Masson C., Batt A. M., Delatour P., Siest G. Albendazole sulfonation by rat liver cytochrome P-450c. Journal of Pharmacology and Experimental Therapeutics 1988b; 246: 758–764
  • Steiger U., Cotting J., Reichen J. Albendazole treatment of echinococcosis in humans: effects on microsomal metabolism and drug tolerance. Clinical Pharmacology and Therapeutics 1990; 47: 347–353
  • Tynes R. E., Hodgson E. Oxidation of Thiobenzamide by the FAD containing and cytochrome P-450 dependent monooxygenases of liver and lung microsomes. Biochemical Pharmacology 1983; 32: 3419–3428
  • Villaverde C., Alvarez A. I., Del Estal J. L., Prieto J. G. Albendazole and Mebendazole uptake by isolated enterocytes. Developmental Pharmacology and Therapeutics 1992; 19: 27–31
  • Watkins P. B. Drug metabolism by cytochromes P450 in the liver and small bowel. Gastrointestinal Pharmacology 1992; 21: 511–526

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