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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 6
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Original Article

Enantioselective metabolism and pharmacokinetics of Casodex in the male rat

D. McKillop Drug Kinetics Group, Safety of Medicines Department, ZENECA Pharmaceuticals, Alderley Park, Macclesfield, SK10 4TG, UK
,
P. J. Simons Drug Kinetics Group, Safety of Medicines Department, ZENECA Pharmaceuticals, Alderley Park, Macclesfield, SK10 4TG, UK
,
I. D. Cockshott Drug Kinetics Group, Safety of Medicines Department, ZENECA Pharmaceuticals, Alderley Park, Macclesfield, SK10 4TG, UK
,
S. J. Hill Drug Kinetics Group, Safety of Medicines Department, ZENECA Pharmaceuticals, Alderley Park, Macclesfield, SK10 4TG, UK
,
J. R. Harding Drug Kinetics Group, Safety of Medicines Department, ZENECA Pharmaceuticals, Alderley Park, Macclesfield, SK10 4TG, UK
,
K. J. Cooper Drug Kinetics Group, Safety of Medicines Department, ZENECA Pharmaceuticals, Alderley Park, Macclesfield, SK10 4TG, UK
&
D. C. Jones Drug Kinetics Group, Safety of Medicines Department, ZENECA Pharmaceuticals, Alderley Park, Macclesfield, SK10 4TG, UK
 show all
Pages 623-633 | Received 19 Dec 1994, Published online: 27 Aug 2009

References

  • Boyle G. W., McKillop D., Phillips P. J., Harding J. R., Pickford R., McCormick A. D. Metabolism of Casodex in laboratory animals. Xenobiotica 1993; 23: 781–798
  • Campbell D. B. Stereoselectivity in clinical pharmacokinetics and drug development. European Journal of Drug Metabolism and Pharmacokinetics 1990; 15: 109–125
  • Caldwell J. The importance of stereochemistry in drug action and disposition. Journal of Clinical Pharmacology 1992; 32: 925–929
  • Cockshott I. D., Cooper K. J., Sweetmore D. S., Blacklock N. J., Denis L. The pharmacokinetics of Casodex in prostate cancer patients after single and multiple dosing. European Urology 1990; 18(Suppl. 3)10–17
  • Cockshott I. D., Plummer G. F., Cooper K. J., Warwick M. J. The pharmacokinetics of Casodex in laboratory animals. Xenobiotica 1991; 21: 1347–1355
  • Cockshott I. D., Sotaniemi E. A., Cooper K. J., Jones D. C. The pharmacokinetics of Casodex enantiomers in subjects with impaired liver function. British Journal of Clinical Pharmacology 1993; 36: 339–343
  • Cook C. E., Seltzman T. B., Tallent C. R., Lorenzo B., Drayer D. E. Pharmacokinetics of pentobarbital enantiomers as determined by enantioselective radioimmunoassay after administration of racemate to humans and rabbits. Journal of Pharmacology and Experimental Therapeutics 1987; 241: 779–785
  • Fujimaki M., Shintani S., Hakusui H. Stereoselective metabolism of carvedilol in the rat. Drug Metabolism and Disposition 1991; 19: 749–753
  • Furr B. J. A. Casodex (ICI 176,334)—a new, pure, peripherally selective antiandrogen: preclinical studies. Hormone Research 1989; 32(suppl. 1)69–76
  • Hewick D. S., McEwan J. Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man. Journal of Pharmacy and Pharmacology 1973; 25: 458–467
  • Hutt A. J., Caldwell J. The metabolic chiral inversion of 2-arylpropionic acids–a novel route with pharmacological consequences. Journal of Pharmacy and Pharmacology 1983; 35: 693–704
  • Jamali F., Mehvar R., Pasutto F. M. Enantioselective aspects of drug action and disposition: therapeutic pitfalls. Journal of Pharmaceutical Sciences 1989; 78: 695–715
  • McKillop D., Boyle G. W., Cockshott I. D., Jones D. C., Phillips P. J., Yates R. A. Metabolism and enantioselective pharmacokinetics of Casodex in man. Xenobiotica 1993; 23: 1241–1253
  • Sisenwine S. F., Tio C. O., Hadley F. V., Liu A. L., Kimmel H. B., Ruelius H. W. Species-related differences in the stereoselective glucuronidation of oxazepam. Drug Metabolism and Disposition 1982; 10: 605–608
  • Tomlinson P. W., Jeffery D. J., Filer C. W. A novel technique for assessment of biliary secretion and enterohepatic circulation in the unrestrained conscious rat. Xenobiotica 1981; 11: 863–870
  • Tomlinson P. W., Ramji J. V., Filer C. W. Disposition of the enantiomers of cromakalim in rat and cynomolgus monkey. Xenobiotica 1992; 22: 799–814
  • Tucker H., Chesterson G. J. Resolution of the nonsteroidal antiandrogen 4′-cyano-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-31-(trifluormethyl)- propionanilide and the determination of the absolute configuration of the active enantiomer. Journal of Medicinal Chemistry 1988; 31: 885–887
  • Tucker H., Crook J. W., Chesterson G. J. Nonsteroidal antiandrogens. Synthesis and structure—activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides. Journal of Medicinal Chemistry 1988; 31: 954–959
  • Yacobi A., Levy G. Pharmacokinetics of the warfarin enantiomers in rats. Journal of Pharmacokinetics and Biopharmaceutics 1974; 2: 239–255

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