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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 10
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Research Article

Effect of cyclophosphamide administration on the activity and relative content of hepatic P4502D1 in rat

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Pages 1031-1039 | Received 01 Apr 1995, Published online: 22 Sep 2008

References

  • Brosen K., Gram L. F. Clinical significance of the sparteine/debrisoquine oxidation polymorphism. European Journal of Clinical Pharmacology 1989; 36: 537–547
  • Daly A. K., Cholerton S., Gregory W., Idle J. R. Metabolic polymorphisms. Pharmacology and Therapeutics 1993; 57: 129–160
  • Evans W. E., Relling M. V., Rahman A., McLeod H. L., Scott E. P., Lin J. Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans. Journal of Clinical Investigation 1993; 91: 2150–2154
  • Gonzalez F. J. Control of constitutively-expressed developmentally-activated rat hepatic cytochrome P450 genes. Keio Journal of Medicine 1992; 41: 68–75
  • Gonzalez F. J., Matsunaga T., Nagata K., Meyer U. A., Nebert D. W., Pastewka J., Kozak C. A., Gillette J., Gelboin H. V., Hardwick J. P. Debrisoquine 4-hydroxylase: Characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. DNA 1987; 6: 149–161
  • Gonzalez F. J., Vilbois F., Hrdwick J. P., McBride O. W., Nebert D. W., Gelboin H. V., Meyer U. A. Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. Genomics 1988; 2: 174–179
  • Kerry N. L., Somogyi A. A., Mikus G., Bochner F. Primary and secondary oxidative metabolism of dextromethorphan: in vitro studies with female Sprague-Dawley and Dark Agouti rat liver microsomes. Biochemical Pharmacology 1993; 45: 833–839
  • Kitada M., Sakamoto K., Rikihisa T., Kanakubo Y. The interaction between two forms of cytochrome P-450 during drug oxidation in the reconstituted system containing limited amount of NADPH-cytochrome P-450 reductase. Biochemical Pharmacology 1984; 33: 3971–3976
  • Küpfer A., Schmid B., Preisig R., Pfaff G. Dextromethorphan as a safe probe for debrisoquine hydroxylation polymorphism. Lancet 1984; ii: 517–518
  • Larrey D., Distlerath L. M., Dannan G. A., Wilkinson G. R., Guengerich F. P. Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism. Biochemistry 1984; 23: 2787–2795
  • Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–685
  • Lear L., Nation R. L., Stupans I. Influence of morphine concentration on detergent activation of rat liver morphine-UDP-glucuronosyltransferase. Biochemical Pharmacology 1991; 42(Suppl.)S55–60
  • Lear L., Nation R. L., Stupans I. Effects of cyclophosphamide and adriamycin on rat hepatic microsomal glucuronidation and lipid peroxidation. Biochemical Pharmacology 1992; 44: 747–753
  • LeBlanc G. A., Waxman D. J. Mechanisms of cyclophosphamide action on hepatic P-450 expression. Cancer Research 1990; 50: 5720–5726
  • Le Guellec C., Lacarelle B., Catalin J., Durand A. Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemotherapy and Pharmacology 1993; 32: 491–495
  • Lewis D. F. V., Moereels H. The sequence homologies of cytothromes P-450 and active-site geometries. Journal of Computer-Aided Molecular Design 1992; 6: 235–252
  • McClure M. T., Stupans I. Investigation of the mechanism by which cyclophosphamide alters cytochrome P450 in male rats. Biochemical Pharmacology 1992; 43: 2655–2658
  • McClure M. T., Stupans I. Hormonal perturbation as a possible mechanism for the alteration of cytochrome P450 by cyclophosphamide. Biochemical Pharmacology 1995; 49: 1827–1836
  • Miwa G. T., West S. B., Lu A. Y. H. Stidies on the rate-limiting enzyme component in the microsomal monooxygenase system: incorporation of purified NADPH-cytochrome c reductase and cytochrome P-450 into rat liver microsomes. Journal of Biological Chemistry 1978; 253: 1921–1929
  • Mortimer Ö., Lindström B., Laurell H., Bergman U., Rane A. Dextromethorphan: polymorphic serum pattern of the O-demethylated and didemethylated metabolites in man. British Journal of Clinical Pharmacology 1989; 27: 223–227
  • Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry 1964; 239: 2370–2378
  • Porter T. D., Coon M. J. Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms. Journal of Biological Chemistry 1991; 266: 13469–13472
  • Relling M. V., Evans W. E., Fonné Pfster R., Meyer U. A. Anticancer drugs as inhibitors of two polymorphic cytochrome P450 enzymes, debrisoquine and mephenytoin hydroxylase, in human liver microsomes. Cancer Research 1989; 49: 68–71
  • Rizzardini M., Ferraroli A., Dal Flume D., Cantoni L. Cyclophosphamide-impaired regulation of hepatic heme metabolism. Experientia 1984; 40: 1390–1392
  • Sladek N. E., Powers J. F., Grage G. M. Half-life of oxazaphosphorines in biological fluids. Drug Metabolism and Disposition 1984; 12: 553–559
  • Soucek P., Gut I. Cytochromes P-450 in rats: structures, functions, properties and relevant human forms. Xenobiotica 1992; 22: 83–103
  • Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences, USA 1979; 76: 4350–4354
  • Treluyer J., Jacqz-Aigrain E., Alvarez F., Cresteil T. Expression of CYP2D6 in developing human liver. European Journal of Biochemistry 1991; 202: 583–588
  • Truan G., Cullin C., Reisdorf P., Urban P., Pompon D. Enhanced in vivo monooxygenase activities of mammalian P450s in engineered yeast cells producing high levels of NADPH-P450 reductase and cytochrome b5. Gene 1993; 125: 49–55
  • Yamamoto A M., Cresteil D., Boniface O., Clerc F. F., Alverez F. Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti-liver-kidney microsome type-1 antibodies (LKM1). European Journal of Immunology 1993a; 23: 1105–1111
  • Yamamoto A. M., Mura C., De Lemos-Chiarandini C., Krishnamoorthy R., Alverez F. Cytochrome P450IID6 recognized by LKM1 antibody is not exposed on the surface of hepatocytes. Clinical and Experimental Immunology 1993b; 92: 381–390
  • Zysset T., Zeugin T., Küpfer A. In-vivo and in-vitro dextromethorphan metabolism in SD and DA rat. An animal model of the debrisoquine-type polymorphic oxidation in man. Biochemical Pharmacology 1988; 37: 3155–3160

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