Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 10
12
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Changes in the metabolism of three model substrates catalysed by different P450 isozymes when administered as a cocktail to the carbon tetrachloride-intoxicated rat

, &
Pages 1111-1118 | Received 06 Mar 1995, Published online: 22 Sep 2008

References

  • Barcetzi M. J., Aoyama T., Gonzalez F. J., Meyer U. A. Lidocaine metabolism in human liver microsomes by cytochrome P450 IIIA4. Clinical Pharmacology and Therapeutics 1989; 46: 521–527
  • Bienvenu T., Pons G., Rey E., Thiroux G., Olive G. Effect of pregnandiol on caffeine metabolismin female rats. European Journal of Drug Metabolism and Pharmacokinetics 1993; 18: 181–185
  • Blaschke T. F., Meffin P. J., Melmon K. L., Rowland M. Influence of acute viral hepatitis on phenytoin kinetics and protein binding. Clinical Pharmacology and Therapeutics 1975; 17: 685–691
  • Breimer D. D. Assesment of drug oxidation in man in vivo. Human Drug Metabolism, E. H. Jeffery. CRC Press, London 1993; 35–42
  • Brosen K. Recent developments in hepatic drug oxidation: implication for clinical pharmacokinetics. Clinical Pharmacokinetics 1990; 18: 220–239
  • Buters J. T. B., Zysset T., Reichen J. Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Biochemical Pharmacology 1991; 46: 983–991
  • Butler M. A., Iwasaki M., Guengerich F. P., Kadlubar F. F. Human cytochrome P-450 pa (P-450 1A2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethyiation of caffeine and N-oxidation of carcinogenic arylamines. Proceedings of the National Academy of Sciences of the United States of America 1989; 86: 7696–7700
  • Dickinson R. G., Hooper W. D., Patterson M., Eadie M. J., Maguire B. Extent of urinary excretion of p-hydroxyphenytoin in healthy subjects given phenytoin. Therapeutic Drug Montoring 1985; 7: 283–289
  • Glazko A. J., Peterson F. E., Chang T., Dil W. A., Smith T. C., Buchanan R. A. Phenytoin metabolism in subjects with long and short plasma half-lives. Therapeutic Drug Monitoring 1982; 4: 281–292
  • Gonzalez F. J., Idle J. R. Pharmacogentic phenotyping and genotyping: present status and future potential. Clinical Pharmacokinetics 1994; 26: 59–70
  • Guengerich F. P. Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity. Toxicology Letters 1994; 70: 133–138
  • Guengerich F. P., Turvy C. G. Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples. Journal of Pharmacology and Experimental Therapeutics 1991; 256: 1189–1993
  • Kolars J. C., Murray S. A., Peters K. M., Watkins P. B. Differential regulation of liver P-450III cytochromes in choline-deficient rats: implications for the eryhromycin breath test as a parameter of liver function. Hepatology 1990; 12: 1371–1378
  • Lown K., Kolars, Turgeon K., Merion R., Wrighton S. A., Watkins P. B. The erythromycin breath test selectively measures P450 IIIA in patients with severe liver disease. Clinical Pharmacology and Therapeutics 1992; 51: 229–238
  • McLean A. J., Morgan D. J. Clinical pharmacokinetics in patients with liver disease. Clinical Pharmacokinetics 1991; 21: 42–69
  • Nakamura M., Tanaka E., Misawa S., Shimada T., Imaoka S., Funae Y. Trimethadione metabolism a useful indicator for assessing hepatic drug-oxidizing capacity. Biochemical Pharmacology 1994; 47: 247–251
  • Oellerich M., Burdelkski M., Ringe B., Lamesch P., Gubernatis G., Bunzendahl H., Pichimayr R., Herrmann H. Lighocaine metabolite formation as a measure of pre-transplant liver function. Lancet 1989; i: 640–642
  • Pelkonen O., Breimer D. D. Role of environmental factors in the pharmacokinetics of drugs: considerations with respect to animal models, P-450 enzymes, and probe drugs. Handbook of Experimental Pharmacology, P. G. Welling, L. P. Balant. Springer, Berlin 1994; 289–332
  • Shimada T., Yamazaki H., Mimura M., Inui Y., Guengerich F. P. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of Pharmacology and Experimental Therapeutics 1994; 270: 414–423
  • Soucek P., Gut I. Cytochrome P-450 in rats: structures, functions, properties and relevant human forms. Xenobiotica 1992; 22: 83–103
  • Tanaka E. Simultaneous determination of caffeine and its primary demethylated metabolites in human plasma by high-performance liquid chromatography. Journal of Chromatography Biomedical Applications 1992; 575: 311–314
  • Tanaka E. Changes in caffeine, lidocaine and trimethadione metabolism in carbon tetrachloride-intoxicated rats as assessed by a ‘Cocktail’ study. Pharmacology and Toxicology 1994a; 75: 150–153
  • Tanaka E., Etoh H., Ishikawa A., Nakano M., Misawa S. Influence of liver damage on antipyrine metabolite formation in rats. Xenobiotica 1991; 22: 535–541
  • Tanaka E., Ishikawa A., Ono A., Okamura T., Kobayashi S., Yasuhara H., Misawa S. Trimethadione tolerance test for evaluation of functional reserved of the liver in patients with liver cirrhosis and esophageal varices. Journal of Pharmacobio-Dynamics 1986a; 9: 297–302
  • Tanaka E., Ishihkawa A., Ono A., Takada A., Okamura T., Misawa S. Hepatic trimethadione-oxidizing capacity remains normal in patients with extrahepatic cholelithiasis. Journal of Pharmacobio-Dynamics 1986b; 9: 506–509
  • Tanaka E., Kinoshits H., Yoshida T., Kuroiwa Y. Determination of plasma trimethadione and its metabolite in carbon tetrachloride intoxicated rat liver: a useful tool for estimation of hepatic drug-metabolizing capacity. Journal of Pharmacobio-Dynamics 1981; 4: 961–967
  • Tanaka E., Kinoshita H., Yoshida T., Kuroiwa Y. Trimethadione as a model drug for the evaluation of hepatic drug-metabolizing capacity in normal and α-naphthylisothiocyanate intoxicated rats. Pharmacology 1982a; 25: 202–209
  • Tanaka E., Kinoshita H., Yoshida T., Kuroiwa Y. Trimethadione as a model drug for the evaluation of hepatic drug-metabolizing capacity in normal and D-galactosamine intoxicated rats. Japanese Journal of Pharmacology 1982b; 32: 1182–1185
  • Tanaka E., Yamamoto Y., Ishikawa A., Osada A., Tsuji K., Fukao K. Effect of cigarette smoking on caffeine and trimethadione N-demethylation catalyzed by different cytochrome P450 isozymes in patients with cirrhosis. International Hepatology Communications 1994b; 2: 341–346
  • Veronese M. E., Doecke C. J., Mackenzie P. I., McManus M. E., Miners J. O., Rees D. L. P., Gasser R., Meyer U. A., Birkett D. J. Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily. Biochemical Journal 1993; 289: 533–538
  • Veronese M. E., Mackenzie P. I., Doecke C. J., MacManus M. E., Miners J. O., Birkett D. J. Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytchrome P4502C9. Biochemical and Biophysical Research Communications 1991; 175: 1112–1118

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.