Hydroxyethyl cyclosporin A induces and decreases P4503A and P-glycoprotein levels in rat liver

References

• AUGUSTINE, J. A., and ZE.MAITIS, M. A., 1986, The effects of cyclosporin A (CsA) on hepatic microsomal drug metabolism in the rat. Drug Metabolism and Disposition, 14, 73–78.
   Google Scholar
• AUGUSTINE, J. A., and ZEMAITIS, M. A., 1989, A comparison of the effects of cyclosporine (CSA) on hepatic microsomal drug metabolism in three different strains of rat. General Pharmacology, 20, 137–141.
   PubMedGoogle Scholar
• BAUMANN, G-, ANDERSEN, E., QUESNIAUX, V., and EBERLE, M. K., 1992, Cyclosporine and its analogue SDZ IMM 125 mediate very similar effects on T-cell activation. A comparative analysis in vitro. Transplantation Proceedings, 24, 43–48.
   Google Scholar
• BERTRAULT-PERES, P., BONKILS, C, FABRE, G., JUST, S., CANO, J. P., and MAUREL, P., 1987, Metabolism of cyclosporin A. II. Implication of the macrolide antibiotic inducible cytochrome P-450 3c from rabbit liver microsomes. Drug Metabolism and Disposition, 15, 391–398.
   Google Scholar
• BRUELISAUER, A., KAWAI, R, MISSLIN, P., and LEMAIRE, M., 1994, Absorption and disposition of SDZ IMM 125, a new cyclosporine derivative, in rats after single and repeated administration. Drug Metabolism and Disposition, 22, 194–199.
   PubMed Web of Science ®Google Scholar
• CARROLL, M. A., QLILLEY, C. P., andMcGiFF, J. C, 1991, Novel araehidonate metabolites generated by cytochrome P450-dependent mono-oxigenases. Pharmacology Research, 23, 309–318.
   Google Scholar
• CHAN, H. S. L., THORNER, P. S., HADDAD, G, and LING, V., 1990, Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood. Journal of Clinical Oncology, 8, 689–704.
   Google Scholar
• CHEN, Y. L., LE VRAUX, V., LENEVEU, A., DREYFUS, F., STHENEUR, A., FLORENTIN, I., DE SOUSA, M., GTROUD, J. P., FLOUVAT, B., and CHAUVELOT-MOACHON, L., 1994, Acute-phase response, interleukin-6, and alteration of cyclosporine pharmacokinetics. Clinical Pharmacology and Therapeutics, 55, 649–660.
   Google Scholar
• COMBALBERT, J., FABRE, I., FABRE, G., DALET, I., DERANCOURT, J., CANO, J. P., and MAUREL, P., 1989, Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily. Drug Metabolism and Disposition, 34, 197–207.
   Google Scholar
• CUNNINGHAM, C, WHITING, P. H., BURKE, M. D., WIIEATLEY, D. N., and SIMPSON, J. G., 1983, Increasing the hepatic metabolism of cyclosporin abolishes nephrotoxicity. Transplantation Proceedings, 15 (suppl. 1), 2712–2715.
   Google Scholar
• CUNNINGHAM, C, BURKE, M. D., WHEATHLEY, D. N., THOMSON, A. W., SIMPSON, J. G., and WHITING, P. H., 1985, Amelioration of eyclosporin-induced nephrotoxicity in rats by induction of hepatic drug metabolism. Biochemical Pharmacology, 34, 573–578.
   PubMed Web of Science ®Google Scholar
• FABRE, J. M., PEDROSA, R., BONARDET, A., PICHARD, L., DESCOMPS, B., DOMERGUE, J., BAUMEL, H., and MAUREL, P., 1993, Metabolism of cyclosporine after orthotopic liver transplantation. Biochemical Pharmacology, 46, 1151–1157.
   PubMedGoogle Scholar
• FOXWELL, B.M. J., MACKIE, A., LING, V., and RYFFEL, B., 1989, Identification of the multidrug resistance-related P-glycoprotein as a cyclosporin binding protein. Molecular Pharmacology, 36. 543–546.
   PubMed Web of Science ®Google Scholar
• GANT, T. W., SILVERMAN, J. A., BISGAARD, H. A., BURT, R. K., MARINO, P. A., and THORGEIRSSON, S. S. 1991, Regulation of 2-acetylaminofluorene- and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver. Molecular Carcinogenesis, 4, 499–509.
   PubMed Web of Science ®Google Scholar
• ISOGAI, M., SHIM ADA, N., KAMATAKI, T., IMAOKA, S., and FUNAE, Y., 1993, Changes in the amounts of cytochromes P450 in rat hepatic microsomes produced by cyclosporin A. Xenobiotica, 23, 799–807.
   PubMed Web of Science ®Google Scholar
• KRONBACH, T., FISCHER, V., and MEYER, U. A., 1988, Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clinical Pharmacology and Therapeutics, 43, 630–635.
   PubMed Web of Science ®Google Scholar
• LAKE, E. G., 1987, Preparation and characterization of microsomal fractions for studies of xenobiotic metabolism. In Bine hemic al Toxicology, A Practical Approach, edited by K. Snell and 13. Mullock (IRL: Oxford), pp. 183–216.
   Google Scholar
• LuCEY, M, R., KOI.ARS, J. C, MERLON, R. M., CAMPBELL, D. A., ALDRICH, M., and WATKINS, P. B., 1990, Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 II1A. Lancet, 335, 11–15. "
   Google Scholar
• MAGHKOVA, Z., MOSTECKA, H., SEIFERT, J., and MASE K., 1991, The effect of cyclosporin? A on renal and hepatic microsomal mixed function oxidase systems in rats. Methods and Findings in Experimental and Clinical Pharmacology, 12, 239–244.
   Google Scholar
• MAYER, R. D., HERMAN, S., COCKETT, A. T., and MAINES, M. D., 1989, Differential effects of cyclosporin on hepatic and renal heme, cytochrome P-450 and drug metabolism. Biochemical Pharmacology, 38,1001–1007.
   PubMed Web of Science ®Google Scholar
• MCGIFF, J. C, 1991, Cytochrome P-450 metabolism of arachidonic acid. Annual Reviews of Phar-macology and Toxicology, 31, 339–369.
   PubMed Web of Science ®Google Scholar
• MOOCHHALA, S. M-, and RENTON, K. W-, 1986, Inhibition of hepatic microsomal drug metabolism by the immunosuppressive agent cyclosporin A. Biochemical Pharmacology, 35, 1499–1503.
   Google Scholar
• NAKAMURA, M., IMAOKA, S., MIFRA, K., TANAKA, IL, MISAWA, S., and FINAE, Y., 1994, Induction of cytochrome P450 isozymes in rat renal microsomes by cyclosporin A. Biochemical Pharmacology, 48,1743–1746.
   PubMedGoogle Scholar
• PRUEKSARITANONT, T., ALMIRA CORREIA, M., RETTIE, A. E., SWINNEY, D. C, THOMAS, P. E., and BENET, L. Z., 1993, Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzymes other than cytochromes P-450 3A. Drug Metabolism and Disposition, 21, 730–737.
   PubMed Web of Science ®Google Scholar
• RIFKIND, A. B., GANNON, M., and GROSS, S. S., 1990, Arachidonic acid metabolism by dioxin-induced cytochrome P450: a new hypothesis on the role of P-450 in dioxin toxicity. Biochemical and Biophysical Research Communications, 172, 1180–1188.
   PubMed Web of Science ®Google Scholar
• SACERDOTI, D., BORSATO, M., RICOTTI, P., AMODIO, P., ANGELI, P., FERRARESSO, M., PLEBANI, M., and GATT A., 1991, Increased renal production of cytochrome P450-dependent metabolites of arachidonic acid in cyclosporine-induced nephrotoxicity. In Prostaglandins and Related Comp-ounds, 7th International Conference, Florence, Italy, 28 May-1 June 1990, edited by B. Samuelsson, P. W. Ramwell, R. Paoletti, G. Folco and E. Granstrom (Raven: New York), pp.689–692.
   Google Scholar
• SADRIEH, N-, GHOSAL, A., and THOMAS, P. E., 1993. In vivo effects of cyclosporine A on hepatic and renal drug metabolizing enzymes. The Toxicologist, 13, 1343.
   Google Scholar
• SAEKI, T., UEDA, K., TANIG.AWARA, Y., HORI, R, and ROMANO, T., 1993, Human P-glycoprotein transports cyclosporin A and FK506. Journal of Biological Chemistry, 268, 6077–6080.
   Google Scholar
• SHARMA, R. K., DOIG, M. V., LEWIS, D. F., and GIBSON, G. G., 1989, Role of hepatic and renal cytochrome P-450 IVA1 in the metabolism of lipid substrates. Biochemical Pharmacology, 38, 3621–3629.
   PubMed Web of Science ®Google Scholar
• THORGEIRSSON, S. S., SILVERMAN, J. A., GAN T. \V., and MARINO, P. A, 1991, Multidrug resistance gene family and chemical carcinogens. Pharmacology and Therapeutics, 49, 283–292.
   Google Scholar
• VICKERS, A. K. M., MEYER, E„ DANNECKER, R., KELLER, B., TYNES, R. E., and MAURER, G., 1995, Human liver cytochrome P4503A biotransformation of the cyclosporin derivative SDZ IMM 125. Drug Metabolism and Disposition, 23, 321–326.
   Google Scholar
• VINCENT, S. H., WANG, R W., KARANAM, B. V., KLIMKO, M., ALVARO, R, and CHU;, S-HL., 1991, Effects of the immunosuppressant FK-506 and its analog FK-520 on hepatic and renal cytochrome P450 mixed-function oxidase. Biochemical Pharmacology, 41, 1325–1330.
   Google Scholar
• WAGNER, O., SCHRETBER, E., HEITZ, F., and MAURER, G., 1987, Tissue distribution, disposition and metabolism of cyclosporine in rats. Drug Aletabolism and Disposition, 15, 377–383.
   PubMed Web of Science ®Google Scholar
• YOSHIMURA, R., YOSHIMLRA, N., NAKATANI, T., KLSUNOSE, E., YAMAGLCHI, T., OKA, T., and KI SHIMO T O, T., 1993, The effects of cyclosporin on renal microsomal cytochrome P-450 systems. Clinical Nephrology, 40, 339–345.
   Google Scholar