Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N^G-monomethyl-L-arginine on the hepatic suppression

References

• Abdel-Razzak Z., Loyer P., Fautrel A., Gautier J. -C., Corcos L., Turlin B., Beaune P., Guillouzo A. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Molecular Pharmacology 1993; 44: 707–715
   PubMed Web of Science ®Google Scholar
• Adams L. B., Hibbs J. B., Taintor R. R., Krahenbuhl J. L. Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Journal of Immunology 1990; 144: 2725–2729
   PubMed Web of Science ®Google Scholar
• Araujo F. G. Depletion of CD4+ T cells but not inhibition of the protective activity of IFN-γ prevents cure of toxoplasmosis mediated by drug therapy in mice. Journal of Immunology 1992; 149: 3003–3007
   PubMed Web of Science ®Google Scholar
• Aruoma O. I., Halliwell B., Hoey B. M., Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypo-chlorous acid. Free Radical Biology and Medicine 1989; 6: 593–597
   PubMed Web of Science ®Google Scholar
• Beckman J. S., Beckman T. W., Chen J., Marshall P. A. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proceedings of the National Academy of Sciences, USA 1990; 87: 1620–1624
   PubMed Web of Science ®Google Scholar
• Beckman J. S., Ischiropoulos H., Zhu L., Van der Woerd M., Smith C., Chen J., Harrison J., Martin J. C., Tsai M. Kinetics of superoxide dismutase-and iron-catalyzed nitration of phenolics by peroxynitrite. Archives of Biochemistry and Biophysics 1992; 298: 438–445
   PubMed Web of Science ®Google Scholar
• Bertini R., Bianchi M., Villa P., Ghezzi P. Depression of liver drug metabolism and increase in plasma fibrinogen by interleukin 1 and tumor necrosis factor: a comparison with lymphotoxin and interferon. International Journal of Immunopharmacology 1988; 10: 525–530
   PubMed Web of Science ®Google Scholar
• Billiar T. R., Curran R. D., Harbrecht B. G., Stuehr D. J., Demetris A. J., Simmons R. L. Modulation of nitrogen oxide synthesis in vivo: NG -monomethyl-L-arginine inhibits endotoxin-induced nitrite/nitrate biosynthesis while promoting hepatic damage. Journal of Leukocyte Biology 1990; 48: 565–569
   PubMed Web of Science ®Google Scholar
• Bornheim L. M., Correia A. M. Effect of cannabidiol on cytochrome P-450 isozymes. Biochemical Pharmacology 1989; 38: 2789–2794
   PubMed Web of Science ®Google Scholar
• Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976; 72: 248–254
   PubMed Web of Science ®Google Scholar
• Candolfi E., Hunter C. A., Remington J. S. Mitogen and antigen specific proliferation of T cells in murine toxoplasmosis is inhibited by reactive nitrogen intermediates. Infection and Immunity 1994; 62: 1995–2001
   PubMed Web of Science ®Google Scholar
• Cantoni L., Gibbs A. H., De Matteis F. Loss of haem and haemoproteins during the generation of superoxide anion and hydrogen peroxide: a pathway not involving production of carbon monoxide. International Journal of Biochemistry 1981; 13: 823–830
   PubMedGoogle Scholar
• Combalbert J., Fabre I., Fabre G. Metabolism of cyclosporine A: IV. Purification and identification of the rifamplcin-inducible human liver cytochrome P-450 (cyclosporine A oxidase) as a product of P450IIIA gene subfamily. Drug Metabolism and Disposition 1989; 17: 197–207
   PubMed Web of Science ®Google Scholar
• Conley F. K., Jenkins K. A. Immunohistochemical study of the anatomic relationship of toxoplasma antigens to the inflammatory response in the brains of mice chronically infected with Toxoplasma gondii. Infection and Immunity 1981; 31: 1184–1192
   PubMed Web of Science ®Google Scholar
• Correia M. A. Cytochrome P450 turnover. Cytochrome P450, M. R. Waterman, E. F. Johnson. Academic Press, San Diego 1991; 315–325
   Google Scholar
• Craig P. I., Metha I., Murray M., McDonald D., Astrom A., Van der Meide P. H., Farrell G. C. Interferon down regulates the male-specific cytochrome P450IIIA2 in rat liver. Molecular Pharmacology 1990; 38: 313–318
   PubMed Web of Science ®Google Scholar
• Curran R. D., Billiar T. R., Stuehr D. J., Hoffmann K., Simmons R. L. Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of kupffer cells. Journal of Experimental Medicine 1989; 170: 1769–1774
   PubMed Web of Science ®Google Scholar
• Curran R. D., Ferrari F. K., Kispert P. H., Stadler J., Stuehr D. J., Simmons R. L., Billiar T. R. Nitric oxide and nitric oxide-generating compounds inhibit hepatocyte protein synthesis. FASEB Journal 1991; 5: 2085–2092
   PubMed Web of Science ®Google Scholar
• Delaporte E., Cribb A. E., Renton K. W. Modulation of rat hepatic CYP3A1 induction by the interferon inducer polyinosinic acid-polycytidylic acid (polyIC). Drug Metabolism and Disposition 1993; 21: 520–523
   PubMed Web of Science ®Google Scholar
• Ding A. H., Nathan C. F., Stuehr D. J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Journal of Immunology 1988; 141: 2407–2412
   PubMed Web of Science ®Google Scholar
• Fantuzzi G., Sironi M., Delgado R., Cantoni L., Rizzardini M., Carelli I., Ghiara P., Ghezzi P. Depression of liver metabolism and induction of cytokine release by diphtheria and tetanus toxoids and pertussis vaccines: role of Bordetella pertussis cells in toxicity. Infection and Immunity 1994; 62: 29–32
   PubMed Web of Science ®Google Scholar
• Ghezzi P., Bianchi M., Gianera L., Landolfo S., Salmona M. Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcysteine in mice. Cancer Research 1985; 45: 3444–3447
   PubMed Web of Science ®Google Scholar
• Ghezzi P., Bianchi M., Mantovani A., Spreafico F., Salmona M. Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers. Biochemical and Biophysical Research Communications 1984; 119: 144–149
   PubMed Web of Science ®Google Scholar
• Ghezzi P., Saccardo B., Bianchi M. Induction of xanthine oxidase and heme oxygenase and depression of liver drug metabolism by interferon: a study with different recombinant interferons. Journal of Interferon Research 1986; 6: 251–256
   PubMedGoogle Scholar
• Gooderham N. J., Mannering G. J. Depression of cytochrome P-450 and alternations of protein metabolism in mice treated with the interferon inducer polyriboinosinic acid-poly-ribocytidylic acid. Archives of Biochemistry and Biophysics 1986; 250: 418–425
   PubMed Web of Science ®Google Scholar
• Granger D. L., Cameron M. L., Lee-See K., Hibbs J. B. Role of macrophage-derived nitrogen oxides in antimicrobial function. Mononuclear Phagocytes in Cell Biology, G. Lopez-Berenstein, J. Klostergaards. CRC Press, Boca Raton 1993; 7–30
   Google Scholar
• Green L. C. D., Wagner D. D. A., Glogowski J., Skepper P. L., Wishnok J. S., Tannenbaum S. R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Annals of Biochemistry 1982; 126: 131–138
   Web of Science ®Google Scholar
• Hibbs J. B., Taintor R. R., Vadrin Z., Rachlin E. M. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochemical and Biophysical Research Communications 1988; 157: 87–94
   PubMed Web of Science ®Google Scholar
• Ischiropoulos H., Zhu L., Beckman J. S. Peroxinitrite formation from macrophage-derived nitric oxide. Archives of Biochemistry and Biophysics 1992; 298: 446–451
   PubMed Web of Science ®Google Scholar
• Jefcoate C. R., Gaylor J. L., Calabrese R. L. Ligand interactions with cytochrome P-450. I. Binding of primary amines. Biochemistry 1969; 8: 3455–3463
   PubMed Web of Science ®Google Scholar
• Khatsenko O. G., Gross S. S., Rifkind A. B., Vane J. R. Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants. Proceedings of the National Academy of Sciences, USA 1993; 90: 11147–11151
   PubMed Web of Science ®Google Scholar
• Kolars J. C., Schmiedlin-Ren P., Schuetz J. D., Fang C., Watkins P. B. Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. Journal of Clinical Investigation 1992a; 90: 1871–1878
   PubMed Web of Science ®Google Scholar
• Kolars J. C., Stetson P. L., Rush D. B., Ruwart M. J., Schmiedlin-Ren P., Duell E. A., Voorhees J. J., Watkins P. B. Cyclosporine metabolism by P450IIIA in rat enterocytes — another determinant of oral bioavailability. Transplantation 1992b; 53: 596–602
   PubMed Web of Science ®Google Scholar
• Kronbach T., Fischer V., Meyer U. A. Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clinical Pharmacology and Therapeutics 1988; 43: 630–635
   PubMed Web of Science ®Google Scholar
• Krzanowski J. J. Cytochrome P450 isoforms: regulation during infection, inflammation and by cytokines. Journal of Florida M. A 1991; 78: 517–519
   PubMedGoogle Scholar
• LÄemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–685
   PubMed Web of Science ®Google Scholar
• Mannering G. J., Deloria L. B., Abbot V. Role of xanthine oxidase in the interferon-mediated depression of the hepatic cytochrome P-450 in mice. Cancer Research 1988; 48: 2107–2112
   PubMed Web of Science ®Google Scholar
• Moldéus P., Cotgreave I. A., Berggren M. Lung protection by a thiol-containing antioxidant: N-acetylcysteine. Respiration 1986; 50: 31–42
   PubMed Web of Science ®Google Scholar
• Murray H. W. Macrophage oxygen-dependent killing of intracellular parasites: Toxoplasma and Leishmania. Advances in Experimental Medicine and Biology 1983; 162: 127–143
   PubMed Web of Science ®Google Scholar
• Nash T. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochemical Journal 1953; 55: 416–421
   PubMed Web of Science ®Google Scholar
• Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB Journal 1992; 6: 3051–3064
   PubMed Web of Science ®Google Scholar
• Nathan C. F., Murray H. W., Wiebe M. E., Rubin B. Y. Identification of interferon-γ as the lymphokine that activates human macrophages oxidative metabolism and antimicrobial activity. Journal of Experimental Medicine 1983; 158: 670–689
   PubMed Web of Science ®Google Scholar
• Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. Journal of Biological Chemistry 1964; 239: 2370–2378
   PubMed Web of Science ®Google Scholar
• Paine A. J. The maintenance of cytochrome P-450 in rat hepatocyte culture: Some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system. Chemistry-Biology Interactions 1990; 74: 1–31
   PubMed Web of Science ®Google Scholar
• Paine A. J., Villa P., Hockin L. J. Evidence that ligand formation is a mechanism underlying the maintenance of cytochrome P-450 in rat liver cell culture: Potent maintenance by metyrapone. Biochemical Journal 1980; 188: 937–939
   PubMed Web of Science ®Google Scholar
• Parent C., Belanger P. M., Jutras L., Du Souich P. Effect of inflammation on the rabbit hepatic cytochrome P-450 isoenzymes: alterations in the kinetics and dynamics of tolbutamide. Journal of Pharmacology and Experimental Therapeutics 1992; 261: 780–787
   PubMed Web of Science ®Google Scholar
• Peterson D. A., Peterson D. C., Archer S., Weir E. K. The non specificity of specific nitric oxide synthase inhibitors. Biochemical and Biophysical Research Communications 1992; 187: 797–801
   PubMed Web of Science ®Google Scholar
• Prueksaritanont T., Correia M. A., Retti A. E., Swinney D. C., Thomas P. E., Benet L. Z. Cyclosporine metabolism by rat liver microsomes: evidence for involvement of enzyme(s) other than cytochromes P-4503A. Drug Metabolism and Disposition 1993; 21: 730–737
   PubMed Web of Science ®Google Scholar
• Radi R., Beckman J. S., Bush K. M., Freeman B. A. Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide. Archives of Biochemistry and Biophysics 1991a; 288: 481–487
   PubMed Web of Science ®Google Scholar
• Radi R., Beckman J. S., Bush K. M., Freeman B. A. Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of superoxide and nitric oxide. Journal of Biological Chemistry 1991b; 266: 4244–4250
   PubMed Web of Science ®Google Scholar
• Reiners J. J., Cantu A. R., Rupp T. A. Coordinate modulation of murine hepatic xanthine oxidase activity and the cytochrome P-450 system by interferons. Journal of Interferon Research 1990; 10: 109–118
   PubMedGoogle Scholar
• Renton K. W. Relationships between the enzymes of detoxication and host defense mechanisms. Biological Basis of Detoxication, J. Caldwell, W. B. Jacoby. Academic Press, New York 1983; 307–324
   Google Scholar
• Renton K. W. Alteration of drug biotransformation during the operation of host detense mechanisms in human. Human Drug Metabolism: From Molecular Biology to Man, E. Jeffery. CRC Press, Boca Raton 1993; 143–151
   Google Scholar
• Rubanyi G. M., Ho E. H., Cantor E. H., Lumma W. C., Parker Botelho L. H. Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes. Biochemical and Biophysical Research Communications 1991; 181: 1392–1397
   PubMed Web of Science ®Google Scholar
• Saran M., Michel C., Bors W. Reaction of NO with O(2)(-). Implications for the action of endothelium-derived relaxing factor (EDRF). Free Radicals Research Communications 1990; 10: 221–226
   PubMed Web of Science ®Google Scholar
• Suzuki Y., Orellana M. A., Schreiber R. D., Remington J. S. Interferon-γ: the major mediator of resistance against Toxoplasma gondii. Science 1988; 240: 516–518
   PubMed Web of Science ®Google Scholar
• Watkins P. B. Role of cytochromes P450 in drug metabolism and hepatotoxicity. Seminars in Liver Disease 1990; 10: 235–250
   PubMed Web of Science ®Google Scholar
• Watkins P. B. Drug metabolism by cytochromes P450 in the liver and small bowel. Gastrointestinal Pharmacology 1992; 21: 511–526
   Google Scholar
• Watkins P. B., Wrighton S. A., Schuetz E. G., Molowa D. T., Guzelian P. S. Identification of glucocorticoid-inducible cytochrome P-450 in the intestinal mucosa of rats and man. Journal of Clinical Investigation 1987; 80: 1029–1036
   PubMed Web of Science ®Google Scholar
• Wing E. J., Remington J. S. Studies on the regulation of lymphocyte reactivity by normal and activated macrophages. Cellular Immunology 1977; 30: 108–121
   PubMed Web of Science ®Google Scholar
• Wink D. A., Hanbauer I., Krishna M. C., DeGraff W., Gamson J., Mitchell J. B. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species. Proceedings of the National Academy of Sciences, USA 1993b; 90: 9813–9817
   PubMed Web of Science ®Google Scholar
• Wink D. A., Osawa Y., Darbyshire J. F., Jones C. R., Eshenauer S. C., Nims R. W. Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent. Archives of Biochemistry and Biophysics 1993a; 300: 115–123
   PubMed Web of Science ®Google Scholar
• Wrighton S. A., Maurel P., Schuetz E. G., Watkins P. B., Young B., Guzelian P. S. Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p. Biochemistry 1985a; 24: 2171–2178
   PubMed Web of Science ®Google Scholar
• Wrighton S. A., Schuetz E. G., Watkins P. B., Maurel P., Barwick J., Bailey B. S., Hartle H. T., Young B., Guzelian P. Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat. Molecular Pharmacology 1985b; 28: 312–321
   PubMed Web of Science ®Google Scholar
• Yanagimoto T., Itoh S., Muller-Enoch D., Kamataki T. Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone. Biochimica et Biophysica Acta 1992; 1130: 329–332
   PubMed Web of Science ®Google Scholar