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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 4
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Research Article

Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian populations

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Pages 395-403 | Received 18 Sep 1995, Published online: 22 Sep 2008

References

  • Cashman J. R., Park S. B., Yang Z. C., Wrighton S. A., Jacob P., Benowitz N. L. Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide. Chemical Research in Toxicology 1992; 5: 639–646
  • Cholerton S., Idle M. E., Vas A., Gonzalez F. J., Idle J. R. Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine. Journal of Chromatography 1992; 575: 325–330
  • Crespi C. L., Penman B. W., Leakey J., Arlotto M. P., Stark A., Parkinson A., Turner T., Steimel D. T., Rudo K., Davies R. L., Langenbach R. Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1. Carcinogenesis 1990; 11: 1293–1300
  • Duescher R. J., Elfarra A. A. Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochrmes P450 2A6 and 2E1. Archives of Biochemistry and Biophysics 1994; 311: 342–349
  • Gonzalez F. J. The molecular biology of cytochrome P450s. Pharmacological Reviews 1989; 40: 243–288
  • Gonzalez F. J. Human cytochromes P450: problems and prospects. Trends in Pharmacological Sciences 1992; 13: 346–352
  • Gonzalez F. J., Crespi C. L., Gelbcin H. V. cDNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment. Mutation Research 1991; 247: 113–127
  • Guengerich F. P. Polymorphism of cytochrome P-450 in humans. Trends in Pharmacological Sciences 1989; 10: 107–109
  • Guengerich F. P. Analysis and characterization of enzymes. Principles and Methods of Toxicology, 3rd edn, A. W. Hayes. Raven, New York 1994; 1259–1313
  • Guengerich F. P., Wang P., Davidson N. K. Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Biochemistry 1982; 21: 1698–1706
  • Imai Y., Nakamura M. Point mutation at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (ω-1)-hydroxylase and testosterone 16α-hydroxylase). Biochemical and Biophysical Research Communications 1989; 158: 717–722
  • Iscan M., Rostami H., Guray T., Pelkonen O., Rautio A. Interindividual variability of coumarin 7-hydroxylation in a Turkish population. European Journal of Clinical Pharmacology 1994; 47: 315–318
  • Kaminsky L. S., Fasco M. J., Guengerich F. P. Production and application of antibodies to rat liver cytochrome P-450. Methods in Enzymology 1981; 74: 262–272
  • Lindberg R., Negishi M. Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue. Nature 1989; 339: 632–634
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. L. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Maurice M., Emiliani S., Dalet-Beliche I., Derancourt J., Lange R. Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes. European Journal of Biochemistry 1991; 200: 511–517
  • Mimura M., Baba T., Yamazaki H., Ohmori S., Inui Y., Gonzalez F. J., Guengerich F. P., Shimada T. Characterization of cytochrome P450 2B6 in human liver microsomes. Drug Metabolism and Disposition 1993; 21: 1048–1056
  • Nash J. Conpact Numerical Methods for Computers: Liner Algebra and Function Minimization. Wiley, New York 1979
  • Nelson D. R., Kamataki T., Waxman D. J., Guengerich F. P., Estabrook R. W., Feyereisen R., Gonzalez F. J., Coon M. J., Gunsalus I. C., Gotoh O., Okuda K., Nebert D. W. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA and Cell Biology 1993; 12: 1–51
  • Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry 1964; 239: 2370–2378
  • Pearce R., Greenway D., Parkinson A. Species difference and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation. Archives of Biochemistry and Biophysics 1992; 298: 211–225
  • Rautio A., Kraul H., Kojo A., Salmela E., Pelkonen O. Interindividual variability of coumarin 7-hydroxylation in healthy volunteers. Pharmacogenetics 1992; 2: 227–233
  • Raunio H., Syngelma T., Pasanen M., Juvonen R., Honkakoski P., Kairaluoma M. A., Sotaniemi E., Lang M. A., Pelkonen O. Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse. Biochemical Pharmacology 1988; 37: 3889–3895
  • Shimada T., Nakamura S. Cytochrome P-450-mediated activation of procarcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK1002. Biochemical Pharmacology 1987; 36: 1979–1987
  • Shimada T., Yamazaki H., Mimura M., Inui Y., Guengerich F. P. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of Pharmacology and Experimental Therapeutics 1994; 270: 414–423
  • Taniguchi H., Imai Y., Iyanagi T., Sato R. Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles. Biochimica et Biophysica Acta 1979; 550: 341–356
  • Wrighton S. A., Stevens J. C. The human hepatic cytochromes P450 involved in drug metabolism. Critical Reviews in Toxicology 1992; 22: 1–21
  • Yamano S., Tatsuno J., Gonzalez F. J. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry 1990; 29: 1322–1329
  • Yamazaki H., Guo Z., Persmark M., Mimura M., Inoue K., Guengerich F. P., Shimada T. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Molecular Pharmacology 1994a; 46: 568–577
  • Yamazaki H., Inui Y., Yun C. H., Guengerich F. P., Shimada T. Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes. Carcinogenesis 1992; 13: 1789–1794
  • Yamazaki H., Mimura M., Sugahara C., Shimada T. Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7α- and coumarin 7-hydroxylations. Biochemical Pharmacology 1994b; 48: 1524–1527
  • Yasukochi Y., Masters B. Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography. Journal of Biological Chemistry 1976; 251: 5337–5344
  • Yasumori T., Nagata K., Yang S. K., Chen L. S., Murayama N., Yamazoe Y., Kato R. Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner. Pharmacogenetics 1993; 3: 291–301
  • Yun C H., Shimada T., Guengerich F. P. Purification and characterization of human liver microsomal cytochrome P-450 2A6. Molecular Pharmacology 1991; 40: 679–685

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