Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 5
Submit an article Journal homepage
44
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Application of electrospray mass spectrometry in the identification of intact glucuronide and sulphate conjugates of clozapine in rat

G.-Q. Zhang College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, S7N 5C9
,
G. McKay College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, S7N 5C9
,
J. W. Hubbard College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, S7N 5C9
&
K. K. Midha College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, S7N 5C9
Pages 541-550 | Received 26 Oct 1995, Published online: 22 Sep 2008

References

  • Fischer V., Haar J., Greiner L., Lloyd R., Mason R. Possible role of free radical formation in clozapine (Clozaril)-induced agranulocytosis. Molecular Pharmacology 1991; 40: 846–853
  • Fitton A., Hell R. Clozapine: a review of its pharmacological properties and therapeutic use in the treatment of schizophrenia. Drugs 1990; 40: 722–747
  • Gauch R., Michaelis W. The metabolism of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine (clozapine) in mice, dogs and human subjects. Farmaco 1971; 26: 667–681
  • Gerson S., Meltzer H. Mechanisms of clozapine induced agranulocytosis. Drug Safety 1992; 7(suppl. 1)17–25
  • Kane J., Honigfeld G., Singer J., Meltzer H. Clozapine for the treatment resistant schizophrenic. A double blind comparison with chlorpromazine/benztropine. Archives of General Psychiatry 1988; 45: 789–796
  • Lambert R. Surgery of the Digestive System of the Rat, B. Julien. Charles C. Thomas, Springfield, Illinois 1965
  • Lieberman J., Johns C., Kane J., Rai K., Pisciotta A., Saltz B., Howard A. Clozapine induced agranulocytosis: non-cross-reactivity with other psychotropic drugs. Journal of Clinical Psychiatry 1988; 49: 271–277
  • Mason R., Fischer V. Possible role of free radical formation in drug-induced agranulocytosis. Drug Safety 1992; 7(suppl. 1)45–50
  • Meltzer H., Bastani B., Young Kwon K., Ramirez L., Burnet S., Sharpe J. A prospective study of clozapine in treatment-resistant schizophrenic patients. I. Preliminary report. Psychopharmacology 1989; 99: S68–72
  • Mulder G., Scholtens E., Meijer D. Collection of metabolites from bile and urine from the rat. Methods in Enzymology 1981; 77: 21–30
  • Utrecht J. Metabolism of clozapine by neutrophils. Possible implications for clozapine-induced agranulocytosis. Drug Safety 1992; 7(suppl. 1)51–56
  • Von Stock B., Spiteller G., Heipertz R. Austausch aromatisch gebundenen Halogens gegen OH- und SCH3 bei der Metabolisierung des Clozapins im menschlichen Korper. Arzneimittel-Forschung/Drug Research 1977; 27: 982–990

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.