Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 6
Submit an article Journal homepage
33
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Comparative metabolism and disposition of ethoxyquin in rat and mouse. I. Disposition

J. M. Sanders Chemistry Branch, Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park NC, 32, USA
,
L. T. Burka Chemistry Branch, Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park NC, 32, USA
&
H. B. Matthews Chemistry Branch, Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park NC, 32, USA
Pages 583-595 | Received 16 Oct 1995, Published online: 22 Sep 2008

References

  • Birnbaum L. S., Decad G. M., Matthews H. B. Disposition and excretion of 2,3,7,8-tetrachlorodibenzofuran in the rat. Toxicology and Applied Pharmacology 1980; 55: 342–352
  • Birnbaum L. S., Eastin W. C., Johnson L., Matthews H. B. Disposition of 4,4′-thiobis)6-t-butyl-m-cresol) in rats. Drug Metabolism and Disposition 1983; 11: 537–543
  • Bock K. W., Kahl R., Lilienblum W. Induction of rat hepatic UDP-glucuronsyl-transferases by dietary ethoxyquin. Naunyn-Schmiedeberg's Archives of Pharmacology 1980; 310: 249–252
  • Burka L. T., Sanders J. M., Matthews H. B. Ethoxyquin metabolism in F344 rats and B6C3F1 mice. Xenobiotica 1996; 26: 597–611
  • Burrows D. Contact dermatitis in animal feed mill workers. British Journal of Dermatology 1975; 92: 167–169
  • Derbel M., Igarashi T., Satoh T. Differential induction of glutathione S-transferase subunits by phenobarbital, 3-methylcholanthrene and ethoxyquin in rat liver and kidney. Biochemica et Biophysica Acta 1993; 1158: 175–180
  • Hard G. C., Neal G. E. Sequential study of the chronic nephrotoxicity induced by dietary administration of ethoxyquin in Fischer 344 rats. Fundamental and Applied Toxicology 1992; 18: 278–287
  • Hiroa K., Shinohara Y., Tsuda H., Fukushima S., Takahashi M. Carcinogenic activity of quinoline on rat liver. Cancer Research 1976; 36: 329–335
  • Kahl R. Synthetic antioxidants: biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens. Toxicology 1984; 33: 185–228
  • Kahl R., Netter K. J. Ethoxyquin as an inducer and inhibitor of phenobarbital-type cytochrome P-450 in rat liver microsomes. Toxicology and Applied Pharmacology 1977; 40: 473–483
  • Kim H. L. Accumulation of ethoxyquin in the tissue. Journal of Toxicology and Environmental Health 1991; 33: 229–236
  • Kim H. L., Ray A. C., Calhoun M. C. Ovine urinary metabolites of ethoxyquin. Journal of Toxicology and Environmental Health 1992; 37: 341–347
  • Manson M. M., Green J. A., Driver H. E. Ethoxyquin alone induces preneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B1. Carcinogenesis 1987; 8: 723–728
  • Manson M. M., Green J. A., Wright B. J., Carthew P. Degree of ethoxyquin-induced nephrotoxicity in rat is dependent on age and sex. Archives of Toxicology 1992; 66: 51–56
  • Matthews H. B., Anderson M. W. The distribution and excretion of 2,4,5,2′,5′-pentachlorobiphenyl in the rat. Drug Metabolism and Disposition 1975; 3: 211–219
  • Office of the Federal Register, National Archives and Records Administration (OFR). Code of Federal Regulations, Title 21. Food and Drugs, Part 172.140, 573.380, 573.400. US Government Printing Office, Washington 1990
  • Parke D. V., Rahim A., Walker R. Reversibility of hepatic changes caused by ethoxyquin. Biochemical Pharmacology 1974; 23: 1871–1876
  • Skaare J. U. Studies on the biliary excretion and metabolites of the antioxidant ethoxyquin, 6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline in the rat. Xenobiotica 1979; 9: 659–668
  • Skaare J. U., Nafstad I. The distribution of 14C-ethoxyquin in rat. Acta Pharmacologia et Toxicologica 1979; 44: 303–307
  • Skaare J. U., Solheim E. Studies on the metabolism of the antioxidant ethoxyquin, 6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline in the rat. Xenobiotica 1979; 9: 649–657
  • Taimr L., Prusíková M., Pospísil J. Antioxidants and stabilizers, CXIII. Oxidation products of the antidegradant ethoxyquin. Angewandte Makromolekulore Chemie 1991; 190: 53–65
  • Ter Muelen U., Ende M., Hunneman D. H., Remberg G., Walker R. Metabolic studies on the antioxidant ethoxyquin. Zeitschrift fuer Tierphysiologie, Tierernährung und Futtermittelkunde 1980; 43: 161–168
  • Thorisson S., Gunstone F. D., Hardy R. Some oxidation products of ethoxyquin including those found in autoxidising systems. Chemistry and Physics of Lipids 1992; 60: 263–271
  • US Department of Health and Human Services (Usdhhs). Public Health Service, National Institute for Occupational Safety and Health. Registery of Toxic Effects of Chemical Substances. Washington 1987; 4275
  • US Environmental Protection Agency (Usepa). Office of Pesticide and Toxic Substances. Lithoxyquin, Pesticide Registration Standard. Washington 1981
  • Wilson R. H., DeEds F. Toxicity studies on the antioxidant 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline. Agricultural and Food Chemistry 1959; 7: 203–206
  • Wilson R. H., Thomas J. O., Thompson C. R., Launer H. F., Kohler G. O. Absorption, metabolism, and excretion of the antioxidant, 6-ethoxy-1,2-dihyro-2,2,4-trimethylquinoline. Agricultural and Food Chemistry 1959; 7: 206–209
  • Zachariae H. Ethoxyquin dermatitis. Contact Dermatitis 1978; 4: 117–118

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.