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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 7
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Research Article

A comparative study of precision cut liver slices, hepatocytes, and liver microsomes from the Wistar rat using metronidazole as a model substance

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Pages 709-722 | Received 02 Jan 1996, Published online: 22 Sep 2008

References

  • Allars H., Coleman D., Norton R. S. 1H nuclear magnetic resonance study of metronidazole metabolism by perfused rat liver. European Journal of Drug Metabolism and Pharmacokinetics 1985; 10: 253–260
  • Bader A., Zech K., Crome O., Christians U., Ringe B., Pichlmayr R., Sewing K -FR. Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals. Xenobiotica 1994; 7: 623–633
  • Barr J., Weir A. J., Brendel K., Sipes I. G. Liver slices in dynamic organ culture. I. An alternative in vitro technique for the study of rat hepatic drug metabolism. Xenobiotica 1991; 21: 331–339
  • Bergmeyer H., Bernt E., Hess B. Lactic dehydrogenase. Methods of Enzymatic Analysis, 2nd edition, H. Bergmeyer. Academic, New York 1965; 736–741
  • Bissel D. M., Hammarker L. E., Meyer U. A. Parenchymal cells from adult rat liver in non proliferating monolayer culture. Journal of Cellular Biology 1973; 59: 722–734
  • Braakman I., Pijing T., Verset O., Wert B., Meijer D. K. F., Groothuis B. M. M. Vesicular uptake systems for the cation Lucigenin in the rat hepatocyte. Molecular Pharmacology 1989; 36: 537–542
  • Dogterom P. Development of a simple incubation system for metabolism studies with precision-cut liver slices. Drug Metabolism and Disposition 1993; 21: 699–704
  • Dogterom P., Rothuizen J. A species comparison of tolbutamide metabolism in precision-cut liver slices from rats and dogs. Drug Metabolism and Disposition 1993; 21: 699–710
  • Dich J., Grunnet N. Primary cultures of rat hepatocytes. Methods in Molecular Biology, J. W. Pollard, J. M. Walker. Human Press, Clitton 1990; vol. 5: 161–175
  • Fry J. R., Bridges J. W. Use of primary hepatocyte cultures in biochemical toxicology. Reviews in Biochemical Toxicology 1979; 1: 201–247
  • Guzelian P. S., Bissell D. M., Meyer U. A. Drug metabolism in adult rat hepatocytes in primary culture. Gastroenterology 1977; 72: 1232–1239
  • Ings R. M., McFadzean J. A. The fate of metronidazole and its implications in chemotherapy. Xenobiotica 1975; 5: 223–235
  • Jones D. P. Determination of pyridine dinucleotides in cell extracts by high performance liquid chromatography. Journal of Chromatography A 1981; 225: 446–449
  • Krumdieck C. L., Ernesto Dos Santos J., Ho K. A new instrument for rapid preparation of tissue slices. Analytical Biochemistry 1980; 104: 118–123
  • LaRusso N. F., Lindmark D. G., Müller M. Billary and renal excretion, hepatic metabolism, and hepatic subcellular distribution of metronidazole in rat. Biochemical Pharmacology 1978; 27: 2247–2254
  • Loft S., Poulsen H. E. Metabolism of metronidazole and antipyrine in hepatocytes isolated from mouse and rat. Xenobiotica 1990; 20: 185–191
  • Loft S., Poulsen H. E. Metabolism of metronidazole and antipyrine in isolated rat hepatocytes. Biochemical Pharmacology 1989; 38: 1125–1136
  • Lowry O. H., Rosenbrough N. J., Farr A. L., Randell R. J. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Miller M. G., Beyer J., Hall G. L., Degraffenried L., Adams P. E. Predictive value of liver slices for metabolism and toxicity in vivo: use of acetaminophen as a model hepatoxicant. Toxicology and Applied Pharmacology 1993; 122: 108–116
  • Pahernik S. A., Schmid J., Sauter T., Schildberg F. W., Koebe H. -G. Metabolism of pimobendan in long-term human hepatocyte culture: in vivo-in vitro comparison. Xenobiotica 1995; 25: 811–823
  • Salyers K. L., Barr J., Sipes I. G. In vitro metabolism of theophylline by rat and human liver tissue. Xenobiotica 1994; 24: 389–399
  • Sandker G. W., Vos R. M. E., Delbressine L. P. C., Sloofs M. J. H., Meijer D. K. F., Groothuis G. M. M. Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: analysis of interspecies variability and comparison with metabolism in vivo. Xenobiotica 1994; 24: 143–155
  • Siddiqui W. H., Buttar H. S. Metronidazole: a comparative study of the intravaginal absorption, metabolism and disposition of a single product and commercial formulation. Archives of International Pharmacodynamics 1979; 239: 4–15
  • Smith P. F., Fisher R., Shubat P. J., Gandolfi V. J., Krumdieck C. L., Brendel K. In vitro cytotoxicity of allyl alcohol and bromobenzenes in novel organ culture system. Toxicology and Applied Pharmacology 1987; 87: 509–522
  • Smith P. F., Krack G., McKee R. L., Johnson D. G., Gandolfi V. J., Krumdieck C. L., Brendel K. Maintenance of adult rat liver slices in dynamic organic culture. In vitro 1986; 22: 706–712
  • Thomsen U. G., Cornett C., Tjørnelund J., Hansen S. H. Separation of metronidazole, its major metabolites and their conjugates using dynamically modified silica. Journal of Chromatography A 1995; 697: 175–184
  • Tempelton R. Metabolism and pharmacokinetics of metronidazole: a review. International Congress Serva-Excerpta Medica 1977; 438: 28–49
  • Vallès B., Coassolo P., De Sousa G., Aubert C., Rahmani R. In vitro hepatic biotransformation of molclobemide (Ro 11–1163) in man and rat. Xenobiotica 1993; 23: 1101–1111
  • Vickers A. E. M., Connors S., Zollinger M., Biggi W. A., Larrauri A., Vogelaar J. P. W., Brendel K. The biotransformation of the ergot derivative CQA 206–291 in human, dog, and rat slice cultures and prediction of in vivo plasma clearance. Drug Metabolism and Disposition 1993; 21: 454–459
  • Wright M. C., Paine A. J. Evidence that the loss of rat liver cytochrome P450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or absence of an extracellular matrix. Biochemical Pharmacology 1992; 43: 237–243

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