Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 8
26
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Use of fresh and cryopreserved hepatocytes to study the metabolism of pesticides in food-producing animals and rats

&
Pages 803-811 | Received 12 Jan 1996, Published online: 22 Sep 2008

References

  • Aitio A. A simple and sensitive assay of 7-ethoxycoumarin deethylation. Analytical Biochemistry 1978; 85: 488–491
  • Chesné C., Guyomard C., Grislain L., Clerc C., Fautrel A., Guillouzo A. Use of cryopreserved animal and human hepatocytes for cytotoxicity studies. Toxicology in Vitro 1991; 5: 479–482
  • Dannenberg A. J., Worman H. J., Scarlata S. Developmental changes in the amount and functional state of UDP-glucuronosyltransferase. Biochimica et Biophysica Acta 1992; 1116: 250–255
  • De Sousa G., Dou M., Lacarelle B., Placidi M., Rahmani R. Freshly isolated or cryopreserved human hepatocytes in primary culture: influence of drug metabolism on hepatotoxicity. Toxicology in Vitro 1991; 5: 483–486
  • De Loecker R., Fuller B. J., Gruwez J., De Loecker W. The effects of cryopreservation on membrane integrity, membrane transport, and protein synthesis in rat hepatocytes. Cryobiology 1990; 27: 143–152
  • De Loecker P., Fuller B. J., Koptelov V. A., De Loecker W. Metabolic activity of freshly prepared and cryopreserved hepatocytes in monolayer culture. Cryobiology 1993; 30: 12–18
  • Diener B., Utesch D., Beer N., Dürk H., Oesch F. A method for the cryopreservation of liver parenchymal cells for studies of xenobiotics. Cryobiology 1993; 30: 116–127
  • Gilissen R. A. H. J., Ringer D. P., Stavenuiter H. J. F. C., Mulder G. J., Meerman J. H. N. Sulfation of hydroxylamines and hydroxamic acids in liver cytosol from male and female rats and purified aryl sulfotransferase IV. Carcinogenesis 1992; 13: 1699–1703
  • Großhans F., Kohl W., Mayer F., Rittig F. R. Metabolism of BAS 490 F in animals and plants. Eighth IUPAC International Congress of Pesticide Chemistry, Book of Abstracts. 1994; vol. 1: 364
  • Guillouzo A., Bégué J. M., Maurer G., Koch P. Identification of metabolic pathways of pindolol and fluperlapine in adult human hepatocytes cultures. Xenobiotica 1988; 18: 131–139
  • Habig W. H., Jakoby W. B. Assays for differentiation of glutathione S-transferases. Methods in Enzymology 1981; 77: 398–405
  • Hümpel M., Sostarek D., Gieschen H., Labitzky C. H. R. Studies on the bio-transformation of Ionazolac, bromerguride, lisuride, and terguride in laboratory animals and their hepatocytes. Xenobiotica 1989; 19: 361–377
  • Isom H. C., Secott T., Georgoff I., Woodworth C., Mummaw J. Maintenance of differentiated rat hepatocytes in primary culture. Proceedings of the National Academy of Sciences, USA 1985; 82: 3252–3256
  • Lacarelle B., Marre F., Durand A., Davi H., Rahmani R. Metabolism of minaprine in human and animal hepatocytes and liver microsomes—prediction of metabolism in vivo. Xenobiotica 1991; 21: 317–329
  • Lacarelle K., Van Houdt J., Van Dyck D., Hendrickx J., Bockx M., Hurkmans R., Meuldermans W., Le Jeune L., Lauwers W., Iieykants J. Comparative metabolism of flunarizine in rats, dogs and man: in vitro study with subcellular liver fractions and isolated hepatocytes. Xenobiotica 1992; 22: 815–836
  • Leroy P., Nicolas A., Thiovdellet C., Oster T., Wellman M., Siest G. Rapid liquid chromatographic assay of glutathione in cultured cells. Biomedical Chromatography 1993; 7: 86–89
  • Moldeus P., Högberg J., Orrenius S. Isolation and use of liver cells. Methods in Enzymology 1978; 52: 60–71
  • Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. Journal of Biological Chemistry 1964; 239: 2370–2385
  • Orzechowski A., Schrenk D., Bock K. W. Metabolism of 1- and 2-naphthylamine in isolated rat hepatocytes. Carcinogenesis 1992; 13: 2227–2232
  • Paine A. J. The maintenance of cytochrome P450 in rat hepatocytes culture: some applications of liver cell cultures to the study of drug metabolism, toxicity, and the induction of the P450 system. Chemical-Biological Interactions 1990; 74: 1–31
  • Powis G., Santone K. S., Melder D. C., Thomas L., Moore D. J., Wilke T. J. Cryopreservation of rat and dog hepatocytes for studies of xenobiotic metabolism and activation. Drug Metabolism and Disposition 1987; 15: 826–832
  • Rogiers V., Vercruysse A. Rat hepatocytes cultures and co-cultures in biotransformation studies of xenobiotics. Toxicology 1993; 82: 193–208
  • Rutten A. A. J. J. L., Falke H. E., Catsburg J. F., Wortelboer H. M., Blaauboer B. J., Doorn L., Van Leeuwen F. X. R., Theelen R., Rietjens I. M. C. M. Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations: standardization of assay conditions. Archives of Toxicology 1992; 66: 237–244
  • Van't Klooster G. A. E., Woutersen-Van Nijnanten F. M. A., Blaauboer B. J., Noordhoek J., Van Miert A. S. J. P. A. M. Applicability of cultured hepatocytes derived from goat, sheep and cattle in comparative drug metabolism studies. Xenobiotica 1994; 24: 417–428
  • Utesch D., Diener B., Molitor E., Oesch F., Platt K. L. Characterization of cryopreserved rat liver parenchymal cells by metabolism of diagnostic substrates and activities of related enzymes. Biochemical Pharmacology 1992; 44: 309–315

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.